Research progress of NOD-like signaling pathways and the relationship between NOD and tumor

林巧卫; 张　思; 陆维祺

doi:10.19401/j.cnki.1007-3639.2019.03.011

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Research progress of NOD-like signaling pathways and the relationship between NOD and tumor

更新时间：2026-01-27

- Research progress of NOD-like signaling pathways and the relationship between NOD and tumor
- China Oncology Vol. 29, Issue 3, Pages: 223-228(2019)
- 作者机构：
  
  1. 复旦大学附属中山医院普外科,上海,200032
  2. 复旦大学上海医学院生物化学与分子生物学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2019.03.011
  CLC： R730.2
- Published Online：26 April 2019，
  
  Published：26 April 2019
- 稿件说明：
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林巧卫，张　思，陆维祺. NOD样受体介导的信号转导通路及其与肿瘤关系的研究进展[J]. 中国癌症杂志, 2019, 29(3): 223-228.

林巧卫, 张　思, 陆维祺. Research progress of NOD-like signaling pathways and the relationship between NOD and tumor[J]. China Oncology, 2019, 29(3): 223-228.
林巧卫，张　思，陆维祺. NOD样受体介导的信号转导通路及其与肿瘤关系的研究进展[J]. 中国癌症杂志, 2019, 29(3): 223-228. DOI： 10.19401/j.cnki.1007-3639.2019.03.011.

林巧卫, 张　思, 陆维祺. Research progress of NOD-like signaling pathways and the relationship between NOD and tumor[J]. China Oncology, 2019, 29(3): 223-228. DOI： 10.19401/j.cnki.1007-3639.2019.03.011.

摘要

核苷酸结合寡聚化结构域（nucleotide-binding oligomerization domain，NOD）样受体是一类位于细胞质的模式识别受体，在先天性免疫应答中起着十分重要的作用。NOD样受体被激活后，通过一系列的信号通路，能诱导各种炎症因子的释放。从NOD样受体的组成、NOD样受体介导的信号转导通路以及NOD样受体与肿瘤关系3个方面进行了综述。

Abstract

Nucleotide-binding oligomerization domain (NOD)-like receptor

a member of pathogen recognition receptors existing in the cytoplasm

is of vital importance to innate immunity. NOD-like receptor is activated

it wil induce the release of plenty of inflammatory factors through a variety of signaling pathways. This review presents the constitution of NOD-like receptor

NODmediated signaling pathways and the relationship between NOD-like receptor and tumors.

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