中国癌症杂志 ›› 2019, Vol. 29 ›› Issue (1): 37-44.doi: 10.19401/j.cnki.1007-3639.2019.01.006

• 论著 • 上一篇    下一篇

浸润性三阴性乳腺癌超声特征的临床、病理学及免疫组织化学基础

李佳伟1,时兆婷1,侯英敏2,张 凯1,钱 雨1,曾 炜1,范亦武1,常 才1   

  1. 1. 复旦大学附属肿瘤医院超声科,复旦大学上海医学院肿瘤学系,上海200032 ;
    2. 上海市奉贤区奉城医院超声科,上海 201411
  • 出版日期:2019-01-30 发布日期:2019-02-01
  • 通信作者: 常 才 E-mail: changc61@163.com
  • 基金资助:
    国家自然科学基金(81830058,81627804)。

Clinicopathological and immunohistochemical basis for sonographic characteristics of triple-negative invasive breast cancer

LI Jiawei1, SHI Zhaoting1, HOU Yingmin2, ZHANG Kai1, QIAN Yu1, ZENG Wei1, FAN Yiwu1, CHANG Cai1   

  1. 1.Department of Medical Ultrasound, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; 2. Department of Medical Ultrasound, Fengcheng Hospital, Fengxian District, Shanghai 201411, China
  • Published:2019-01-30 Online:2019-02-01
  • Contact: CHANG Cai E-mail: changc61@163.com

摘要: 背景与目的:三阴性乳腺癌(triple-negative breast cancer,TNBC)细胞增殖程度高,有明显的肿瘤异质性,缺乏针对性治疗药物,是恶性程度最高、预后最差的乳腺癌分子分型。超声是TNBC筛查和鉴别诊断的重要影像学方法之一。TNBC的超声图像特征表现出明显的变异性。该研究旨在探讨临床、病理学及免疫组织化学因素对TNBC超声图像特征的影响。方法:回顾性分析119例手术后经病理学检查证实的浸润性TNBC患者的术前超声图像、临床及病理学资料。2名具有5年以上临床经验的超声科医师对乳腺癌肿块超声图像进行特征分析与评估,评估内容包括肿块的方位、形态、边缘、内部回声、后方回声改变及钙化。按照患者年龄、肿瘤大小、病理组织学级别、Ki-67表达水平及人类表皮生长因子受体2(human epidermal growth factor receptor-2,HER2)评分将患者分组,以研究这些因素对TNBC超声图像特征的影响。结果:浸润性TNBC的超声特征与患者年龄、肿块大小、病理学分级、Ki-67表达水平及HER2评分相关:患者年龄影响肿块的后方回声(P=0.002),肿块大小影响肿块边缘是否毛刺成角(P=0.025),病理学分级影响肿块的形态(P=0.008)及后方回声(P=0.044),Ki-67表达影响肿块的形态(P=0.042)、边缘是否毛刺成角(P=0.005)及后方回声(P=0.005),HER2评分影响钙化的发生率(P=0.024)。结论:浸润性TNBC的超声声像图特征与患者年龄、肿块大小、病理学分级、Ki-67增殖水平及HER2评分有关。了解TNBC的超声特征及变异性相关的临床、病理学及免疫组织化学基础,可辅助早期诊断和提高诊断准确性。

关键词: 三阴性乳腺癌, 超声, 病理学, 免疫组织化学

Abstract: Background and purpose: While being recognized as a heterogeneous disease, triple-negative breast cancer (TNBC) is associated with aggressive biological property, a lack of targeted therapy and poor prognosis. Ultrasonography is one of the most important imaging methods for screening and differential diagnosis of TNBC. The sonographic features of TNBC show great variability. The primary objective of the present study was to evaluate the clinicopathological factors associated with sonographic appearances of invasive TNBC. Methods: With the ethical approval, 119 patients who were pathologically confirmed as having invasive TNBC were retrospectively reviewed for ultrasound, clinical and pathological data. Two ultrasound physicians with at least 5 years’ experiences for breast diseases reviewed all ultrasound images and evaluated the sonographic features which included orientation, shape, margin, internal echo pattern, posterior acoustic pattern and calcification. Patients were grouped according to age, tumor size, histological grade, Ki-67 proliferation level and human epidermal growth factor receptor-2 (HER2) score to investigate the effects of these factors on the ultrasonographic characteristics of TNBC. The effects of clinicopathological factors on the sonographic features of TNBC were studied. Results: The sonographic features of TNBC were associated with patient age, tumor size, histological grade, Ki-67 proliferation level and HER2 score. Age of patient affected the posterior acoustic pattern (P=0.002). Tumor size affected the presence of angular or spiculated margin (P=0.025). Histological grade affected tumor shape (P=0.008) and posterior acoustic pattern (P=0.044). Ki-67 level affected the tumor shape (P=0.042), presence of angular or spiculated margin (P=0.005) and posterior acoustic pattern (P=0.005). HER2 score affected the incidence of calcification inside TNBC (P=0.024). Conclusion: The sonographic features of TNBC are related to the patient’s age, tumor size, histological grade, Ki-67 proliferation level and HER2 score. Understanding the clinicopathological and immunohistochemical basis of sonographic characteristics and variability of TNBC is expected to assist early and accurate diagnosis of TNBC.

Key words: Triple-negative breast cancer, Ultrasonography, Pathology, Immunohistochemistry