中国癌症杂志 ›› 2019, Vol. 29 ›› Issue (3): 223-228.doi: 10.19401/j.cnki.1007-3639.2019.03.011

• 综述 • 上一篇    下一篇

NOD样受体介导的信号转导通路及其与肿瘤关系的研究进展

林巧卫1,张 思2,陆维祺1   

  1. 1. 复旦大学附属中山医院普外科,上海 200032 ;
    2. 复旦大学上海医学院生物化学与分子生物学系,上海 200032
  • 出版日期:2019-03-30 发布日期:2019-04-26
  • 通信作者: 陆维祺 E-mail: lu.weiqi@zs-hospital.sh.cn
  • 基金资助:
    国家自然科学基金(81770137)。

Research progress of NOD-like signaling pathways and the relationship between NOD and tumor

LIN Qiaowei1, ZHANG Si2, LU Weiqi1   

  1. 1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; 2. Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Published:2019-03-30 Online:2019-04-26
  • Contact: LU Weiqi E-mail: lu.weiqi@zs-hospital.sh.cn

摘要: 核苷酸结合寡聚化结构域(nucleotide-binding oligomerization domain,NOD)样受体是一类位于细胞质的模式识别受体,在先天性免疫应答中起着十分重要的作用。NOD样受体被激活后,通过一系列的信号通路,能诱导各种炎症因子的释放。从NOD样受体的组成、NOD样受体介导的信号转导通路以及NOD样受体与肿瘤关系3个方面进行了综述。

关键词: 核苷酸结合寡聚化结构域样受体, 信号通路, 肿瘤

Abstract: Nucleotide-binding oligomerization domain (NOD)-like receptor, a member of pathogen recognition receptors existing in the cytoplasm, is of vital importance to innate immunity. NOD-like receptor is activated, it wil induce the release of plenty of inflammatory factors through a variety of signaling pathways. This review presents the constitution of NOD-like receptor, NODmediated signaling pathways and the relationship between NOD-like receptor and tumors.

Key words: Nucleotide-binding oligomerization domain-like receptor, Signaling pathway, Tumor