Prospero相关同源异形盒蛋白1在乳腺癌组织中的表达及与预后相关性分析

doi:10.19401/j.cnki.1007-3639.2019.04.005

摘要/Abstract

摘要： 背景与目的：Prospero相关同源异形盒蛋白1（prospero-related homeobox 1，PROX1）作为同源域转录因子家族成员，参与多种恶性肿瘤的发生、发展过程，与肿瘤细胞增殖、分化、凋亡、迁移和侵袭过程密切相关。该研究探讨了PROX1在乳腺癌组织中的表达及与预后相关性分析。方法：选取2011年3月—2013年3月在郑州市第三人民医院择期行手术治疗且资料完整的乳腺癌患者85例，采用免疫组织化学染色法检测乳腺癌和癌旁组织中PROX1蛋白水平，所有患者术后随访。随访中，失访4例，随访截止日期为2018年3月31日，生存分析采用Kaplan-Meier法和Log-rank检验，乳腺癌患者预后影响因素分析采用Cox比例风险回归模型。结果：乳腺癌组织中PROX1蛋白阳性率为71.76%，癌旁组织则为28.57%，差异有统计学意义（χ²=32.600，P<0.001）；乳腺癌组织中PROX1蛋白水平在不同分化程度、TNM分期、雌激素受体（estrogen receptor，ER）、Ki-67标记指数和淋巴结转移患者之间的差异有统计学意义（P<0.05）；Kaplan-Meier生存分析结果显示，PROX1阳性表达组平均生存时间为（36.73±2.73）个月，PROX1阴性表达组则为（56.36±2.13）个月，Log-rank检验结果差异有统计学意义（χ²=11.803，P=0.001）；Cox比例风险回归模型结果显示，分化程度、TNM分期、淋巴结转移和PROX1蛋白表达是影响乳腺癌患者预后的风险因素（P<0.05）。结论：PROX1蛋白在乳腺癌组织中呈高表达，且与乳腺癌发生、进展及预后密切相关，是影响患者预后的风险因素。

关键词: 乳腺癌, Prospero相关同源异形盒蛋白1, 预后, Cox比例风险回归模型

Abstract: Background and purpose: Prospero-related homeobox 1 (PROX1), a member of the homeodomain transcription factor family, is involved in the development and progression of a variety of malignant tumors, and is closely related to tumor cell proliferation, differentiation, apoptosis, migration and invasion. This study explored the expression of PROX1 in breast cancer tissues and its correlation with prognosis. Methods: A total of 85 patients with breast cancer underwent elective surgery, and complete data were collected from Mar. 2011 to Mar. 2013. Immunohistochemical staining was used to detect the protein level of PROX1 in breast cancer and adjacent tissues. All patients were followed up, and 4 patients were lost during follow-up. Follow-up deadline was Mar. 31, 2018. Kaplan-Meier method and Log-rank test were used for survival analysis. Cox proportional hazards regression model was used to analyze the prognostic factors of breast cancer. Results: The positive rate of PROX1 protein was 71.76% in breast cancer tissues and 28.57% in adjacent tissues (χ²=32.600, P<0.001). The expression of PROX1 protein in breast cancer tissues was significantly different in the degree of differentiation, TNM stage, estrogen receptor (ER), Ki-67 labeling index and lymph node metastasis compared with adjacent tissues (P<0.05). Kaplan-Meier survival analysis showed that the mean survival time of the PROX1 positive expression group was (36.73±2.73) months, and that of the PROX1 negative expression group was (56.36±2.13) months. The Log-rank test howed the difference in mean survival time was statistically significant between the two groups (χ²=11.803, P=0.001). The Cox proportional hazards regression model showed that the degree of differentiation, TNM stage, lymph node metastasis and PROX1 protein expression were risk factors for the prognosis of breast cancer patients (P<0.05). Conclusion: PROX1 is highly expressed in breast cancer tissues, and is closely related to the occurrence and progression of breast cancer and prognosis of patients. It is a risk factor affecting the prognosis of patients.

Key words: Breast cancer, Prospero-related homeobox 1, Prognosis, Cox proportional hazards regression model

赵东丽，梁宪斌，王艳，张喜凤，张维真. Prospero相关同源异形盒蛋白1在乳腺癌组织中的表达及与预后相关性分析[J]. 中国癌症杂志, 2019, 29(4): 272-276.

ZHAO Dongli, LIANG Xianbin, WANG Yan, ZHANG Xifeng, ZHANG Weizhen. Expression of prospero-related homeobox 1 in breast cancer tissues and its correlation with prognosis[J]. China Oncology, 2019, 29(4): 272-276.

[1]	伍雯, 张若昕, 翁俊勇, 马延磊, 蔡国响, 李心翔, 杨永志. 探索阳性淋巴结比率在ypⅢ期结直肠癌患者中的预后价值及预测模型的建立[J]. 中国癌症杂志, 2024, 34(9): 873-880.
[2]	徐睿, 王泽浩, 吴炅. 肿瘤相关中性粒细胞在乳腺癌发生、发展中的作用研究进展[J]. 中国癌症杂志, 2024, 34(9): 881-889.
[3]	肖锋, 许桐林, 朱琳, 肖静文, 吴天祺, 顾春燕. M1型肿瘤相关巨噬细胞在肝细胞癌组织中浸润的意义[J]. 中国癌症杂志, 2024, 34(8): 726-733.
[4]	曹晓珊, 杨蓓蓓, 丛斌斌, 刘红. 三阴性乳腺癌脑转移治疗的研究进展[J]. 中国癌症杂志, 2024, 34(8): 777-784.
[5]	张剑. 关于女性乳腺癌患者绝经状态判断两个关键问题的临床思考[J]. 中国癌症杂志, 2024, 34(7): 619-627.
[6]	姜丹, 宋国庆, 王晓丹. 乳腺癌中线粒体功能障碍与CPT1A/ERK信号转导通路共同调节乳腺癌恶性行为的机制研究[J]. 中国癌症杂志, 2024, 34(7): 650-658.
[7]	董涧桥, 李坤艳, 李菁, 王斌, 王艳红, 贾红燕. SIRT3通过去乙酰化YME1L1诱导乳腺癌内分泌治疗耐药的作用机制研究[J]. 中国癌症杂志, 2024, 34(6): 537-547.
[8]	唐楠, 黄慧霞, 刘晓健. 利用单细胞测序和转录组测序建立结直肠癌免疫细胞的9基因预后模型[J]. 中国癌症杂志, 2024, 34(6): 548-560.
[9]	郝弦, 黄建军, 杨文秀, 刘晋廷, 张军红, 罗钰蓓, 李青, 王大红, 高玉炜, 谭福云, 薄莉, 郑羽, 王荣, 冯江龙, 李静, 赵春华, 豆晓伟. 乳腺癌原代细胞系为药物筛选和基础研究提供癌症新模型[J]. 中国癌症杂志, 2024, 34(6): 561-570.
[10]	张若昕, 叶紫岚, 翁俊勇, 李心翔. 高龄与Ⅱ期结直肠癌患者预后不良的相关性研究[J]. 中国癌症杂志, 2024, 34(5): 485-492.
[11]	中国抗癌协会乳腺癌专业委员会. 中国早期乳腺癌卵巢功能抑制临床应用专家共识（2024年版）[J]. 中国癌症杂志, 2024, 34(3): 316-333.
[12]	张琪, 修秉虬, 吴炅. 2023年中国乳腺癌重要临床研究成果及最新进展[J]. 中国癌症杂志, 2024, 34(2): 135-142.
[13]	张思源, 江泽飞. 2023年改变晚期乳腺癌临床实践的重要研究成果及进展[J]. 中国癌症杂志, 2024, 34(2): 143-150.
[14]	王昭卜, 黎星, 于鑫淼, 金锋. 2023年改变早期乳腺癌临床实践的重要研究成果及进展[J]. 中国癌症杂志, 2024, 34(2): 151-160.
[15]	罗扬, 孙涛, 邵志敏, 崔久嵬, 潘跃银, 张清媛, 程颖, 李惠平, 杨燕, 叶长生, 于国华, 王京芬, 刘运江, 刘新兰, 周宇红, 柏玉举, 谷元廷, 王晓稼, 徐兵河, 宋礼华. AK-HER2与参照药治疗HER2阳性转移性乳腺癌患者的疗效、体内代谢特征、安全性和免疫原性比较：一项多中心、随机、双盲Ⅲ期等效性临床试验[J]. 中国癌症杂志, 2024, 34(2): 161-175.

Prospero相关同源异形盒蛋白1在乳腺癌组织中的表达及与预后相关性分析

Expression of prospero-related homeobox 1 in breast cancer tissues and its correlation with prognosis

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价