中国癌症杂志 ›› 2020, Vol. 30 ›› Issue (9): 701-706.doi: 10.19401/j.cnki.1007-3639.2020.09.010

• 综述 • 上一篇    下一篇

外泌体作为靶向治疗载体的研究进展

潘星昊,刘明斌,张晓燕,徐建青   

  1. 复旦大学附属公共卫生临床中心,上海 201508
  • 出版日期:2020-09-30 发布日期:2020-10-13
  • 通信作者: 徐建青 E-mail: xujianqing@shphc.org.cn
  • 基金资助:
    国家重点研发计划项目(2016YFC1303402);国家CDC重点实验室(2017SKLID311)。

Advances in research of exosomes as targeted therapeutic vectors

PAN Xinghao, LIU Mingbin, ZHANG Xiaoyan, XU Jianqing   

  1. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China
  • Published:2020-09-30 Online:2020-10-13
  • Contact: XU Jianqing E-mail: xujiangqing@shphc.org.cn

摘要: 外泌体是来源于细胞内膜的纳米级的囊泡,包含有核酸、蛋白和脂质等生命物质,作为一种细胞间交流的机制,在生命活动中发挥着重要作用。相对于脂质体载体,外泌体更稳定,生物相容性好,免疫原性低,而且可以渗透生物屏障,例如血脑屏障、胎盘屏障等。重点介绍外泌体载体靶向性的基础、外泌体载体装载负荷的方法及外泌体载体目前的应用进展和前景。

关键词: 外泌体, 靶向性, 治疗载体

Abstract: Exosomes are nanoscale vesicles derived from the inner membrane of cells, containing life information such as nucleic acids, proteins and lipids. They play an important role in life activities as a mechanism of intercellular communication. Compared to liposome carriers, exosomes are more stable, biocompatible and less immunogenic, and can penetrate biological barriers such as the blood-brain barrier and the placental barrier. This article focused on the basis of exosome vector targeting, the method of carrier loading and the current application progress and prospects.

Key words: Exosomes, Targeting, Therapeutic vector