中国癌症杂志 ›› 2021, Vol. 31 ›› Issue (1): 1-10.doi: 10.19401/j.cnki.1007-3639.2021.01.001

• 专家述评与论著 • 上一篇    下一篇

2020年胰腺癌研究及诊疗新进展

唐 榕,施 思,张 波,徐 近,王 巍,虞先 濬   

  1. 复旦大学附属肿瘤医院胰腺外科,复旦大学上海医学院肿瘤学系,复旦大学胰腺肿瘤研究所,上海市胰腺肿瘤研究所,上海 200032
  • 出版日期:2021-01-30 发布日期:2021-02-20
  • 通信作者: 虞先濬 E-mail: yuxianjun@fudanpci.org
  • 基金资助:
    上海市教育委员会科研创新计划自然科学重大项目(2019-01-07-00-07-E00057);上海市卫健委资助项目[ZY(2018-2020)-CCCX-2005-02];复旦大学先导项目(IDF159029)。

Advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2020

TANG Rong, SHI Si, ZHANG Bo, XU Jin, WANG Wei, YU Xianjun#br#   

  1. Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Pancreatic Cancer Institute, Fudan University; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China
  • Published:2021-01-30 Online:2021-02-20
  • Contact: YU Xianjun E-mail: yuxianjun@fudanpci.org

摘要: 胰腺癌是恶性程度较高的消化道肿瘤之一,由于早期病情隐匿、疾病进展极快、化疗有效率低等原因,胰腺癌患者预后极差,5年总生存率仅约9%。近年来,随着居民饮食结构和生活方式的改变以及临床检出率的提高,胰腺癌发病率逐年升高,严重威胁居民的生命健康。大量基础研究的进展为胰腺癌的治疗提供了更多潜在靶点,高质量临床研究的成果也让更多理论上的创新和突破落到实处,这些都为胰腺癌患者预后的改善带来了新的希望。对2020年胰腺癌研究领域的重大进展进行了综述。

关键词: 胰腺癌, 基础研究, 临床研究

Abstract: Pancreatic cancer is one of the more dismal gastrointestinal tumors due to the obscure symptoms in the early stage of disease, rapid progression and insensitivity to chemotherapy. The 5-year survival rate is only approximately 9% for patients with pancreatic cancer. In the recent years, with the change in dietary structure and life style as well as the improvement of clinical detection rate, the incidence of pancreatic cancer is increasing annually, and it severely undermines the health of people. However, the advance in molecular biology provides more potential targets for the treatment of pancreatic cancer. Besides, well-conducted clinical trials continue to translate more theoretical innovations from bench to bedside. These both can improve the prognosis of pancreatic cancer eventually. The present review summarized the important findings in pancreatic cancer research in 2020.

Key words: Pancreatic cancer, Basic research, Clinical research