中国癌症杂志 ›› 2021, Vol. 31 ›› Issue (11): 1088-1095.doi: 10.19401/j.cnki.1007-3639.2021.11.007

• 论著 • 上一篇    下一篇

血清MIP-1α、S-TK1对于甲状腺癌术后放射性 131 I治疗效果评估的临床价值

武鸿文,梅 艳,王 乔,袁 佳,赵立威   

  1. 四川省肿瘤医院核医学科,四川 成都 610041
  • 出版日期:2021-11-30 发布日期:2021-12-03
  • 通信作者: 武鸿文 E-mail: vy1035beji386@163.com

The clinical value of serum MIP-1α and S-TK1 in the evaluation of postoperative radioactive  131 I treatment for thyroid carcinoma

WU Hongwen, MEI Yan, WANG Qiao, YUAN Jia, ZHAO Liwei   

  1. Department of Nuclear Medicine, Sichuan Cancer Hospital, Chengdu 610041, Sichuan Province, China
  • Published:2021-11-30 Online:2021-12-03
  • Contact: WU Hongwen E-mail: vy1035beji386@163.com

摘要: 背景与目的:血清胸苷激酶1(serum-thymidine kinase 1,S-TK1)、巨噬细胞炎性蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)均是肿瘤血清标志物,其在血清中的水平与甲状腺癌的严重程度、预后密切相关,探讨S-TK1、MIP-1α表达水平对甲状腺癌术后放射性 131 I治疗效果评估的临床价值。方法:选取158例术前疑似甲状腺癌患者作为研究对象,并以128名健康体检者作为对照。比较两组研究对象的血清MIP-1α、S-TK1表达水平,对所有恶性肿瘤患者进行清甲治疗后分为清甲成功组(58例)和未成功组(40例)以及转移阳性组(20例)和转移阴性组(78例),比较各组血清MIP-1α、S-TK1表达水平,采用免疫组织化学染色技术检测两组患者甲状腺组织中MIP-1α、S-TK1表达水平,并对影响术后疗效的相关因素进行单因素和logistic回归分析。结果:与健康对照组和良性组相比,恶性组患者MIP-1α、S-TK1表达水平更高,差异有统计学意义(P < 0.05);术后两次 131 I治疗前清甲成功组血清MIP-1α、S-TK1表达水平相比清甲未成功组显著降低(P < 0.05),转移阳性组患者血清MIP-1α、S-TK1表达水平均显著高于转移阴性组,差异均有统计学意义(P < 0.05)。免疫组织化学染色结果显示,恶性组患者甲状腺组织中MIP-1α蛋白阳性表达率(70.41%)显著高于良性组(18.33%),且恶性组组织中S-TK1蛋白阳性表达率(68.37%)显著高于良性组(15.00%)(P < 0.05)。单因素分析结果表明,病灶最大直径、体重指数(body mass index,BMI)、促甲状腺激素(thyroid-stimulating hormone,TSH)、MIP-1α及S-TK1表达水平对甲状腺癌术后首次 131 I清甲疗效具有明显影响(P < 0.05)。Logistic回归分析结果表明,病灶最大直径、TSH、MIP-1α及S-TK1表达水平是影响术后首次清甲疗效的独立影响因素(P < 0.05)。结论:甲状腺癌患者血清MIP-1α、S-TK1表达水平显著高于健康人群,甲状腺癌患者发生转移后MIP-1α、S-TK1表达水平显著升高。病灶最大直径、TSH、MIP-1α及S-TK1表达水平是影响术后首次清甲疗效的独立影响因素。

关键词: 甲状腺癌, 血清胸苷激酶1, 巨噬细胞炎性蛋白-1α, 疗效评估

Abstract: Background and purpose: Serum-thymidine kinase 1 (S-TK1) and macrophage inflammatory protein-1α (MIP-1α) are serum tumor markers, and their expression levels in serum are closely associated with disease severity and prognosis of thyroid cancer patient. Therefore, this article aimed to explore clinical value of the expression levels of S-TK1 and MIP-1α in the evaluation of postoperative radioactive  131 I treatment for thyroid carcinoma. Methods: A total of 158 preoperative patients with thyroid cancer and 128 healthy subjects were selected as study group and control group. Serum MIP-1α and S-TK1 levels were compared between the two groups. All patients with malignancy were divided into groups: the successful group (58 cases) and the unsuccessful group (40 cases), the metastasis positive group (20 cases) and the metastasis negative group (78 cases). The levels of serum MIP-1α and S-TK1 were compared, and immunohistochemical staining technique was used to detect the expressions of MIP-1α and S-TK1 in the thyroid tissues of different groups of patients. The factors affecting postoperative outcome were analyzed by single factor and logistic regression analysis. Results: The expression levels of MIP-1α and S-TK1 were significantly higher in the thyroid malignant group than in the benign group and the healthy control group (P < 0.05). Compared with those who were unsuccessful, the serum expression levels of MIP-1α and S-TK1 in the successful group before the  131 I treatment were significantly reduced (P < 0.05). The serum levels of MIP-1α and S-TK1 were significantly higher in the metastasis positive group than in the metastatic negative group (P < 0.05). Immunohistochemical staining results showed that the positive expression rate of MIP-1α protein in the thyroid tissues of the malignant group (70.41%) was significantly higher than in the benign group (18.33%), and the positive expression rate of S-TK1 protein was significantly higher in the malignant group (68.37%) than in the benign group (15.00%) (P < 0.05). Univariate analysis showed that maximum diameter, body mass index (BMI), thyroid-stimulating hormone (TSH), the expression levels of MIP- 1α and S-TK1 had significant effects on the first postoperative  131 I clearing effect in patients with thyroid cancer (P < 0.05). Logistic regression analysis showed the largest diameter of the lesion and the expression levels of TSH, MIP-1α and S-TK1 were independent factors influencing the efficacy of the first postoperative clearing effect (P < 0.05). Conclusion: The expression levels of MIP-1α and S-TK1 are significantly higher in thyroid cancer patients than in healthy people. The expression levels of MIP-1α and S-TK1 are significantly increased after metastasis in thyroid cancer patients, and the maximum diameter of lesion, TSH and the expression levels of MIP-1α and S-TK1 are independent factors affecting the efficacy of the first postoperative clearing effect (P < 0.05).

Key words: Thyroid cancer, Serum thymidine kinase 1, Macrophage inflammatory protein-1α, Curative effect evaluation