外周血HER2基因扩增检测（数字PCR法）在抗HER2治疗中的应用共识

doi:10.19401/j.cnki.1007-3639.2022.01.012

摘要/Abstract

Key words: Human epidermal growth factor receptor 2, Gene amplification, Digital polymerase chain reaction, Consensus

中图分类号:

R737.9

卢仁泉, 柳光宇, 杨文涛, 郭林, 关明, 邵志敏, 徐大志, 倪明, 唐峰, 王朝夫, 娄加陶, 孙奋勇, 邢金良, 潘跃银. 外周血HER2基因扩增检测（数字PCR法）在抗HER2治疗中的应用共识[J]. 中国癌症杂志, 2022, 32(1): 90-96.

LU Renquan, LIU Guangyu, YANG Wentao, GUO Lin, GUAN Ming, SHAO Zhimin, XU Dazhi, NI Ming, TANG Feng, WANG Chaofu, LOU Jiatao, SUN Fenyong, XING Jinliang, PAN Yueyin. Application consensus of peripheral blood HER2 gene amplification detection (digital PCR) in anti-HER2 therapy[J]. China Oncology, 2022, 32(1): 90-96.

图/表 2

参考文献 25

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Detection result of dPCR	Detection results of gold standard for tissue sample detection (ICH combined with FISH)		Total
Detection result of dPCR	Positive	Negative	Total
Positive	42	20	62
Negative	54	106	160
Total	96	126	222

Item	Newly diagnosed stage Ⅲ patients (n=70)	Newly diagnosed stage Ⅳ patients (n=93)	Patients with recurrence and metastasis (n=59)
Sensitivity	37.93% (11/29)	41.67% (15/36)	51.61% (16/31)
Specificity	92.68% (38/41)	85.96% (49/57)	67.86% (19/28)
Total consistent rate	70.00% (49/70)	68.82% (64/93)	59.32% (35/59)
Kappa	0.331 2	0.296 0	0.192 7

外周血HER2基因扩增检测（数字PCR法）在抗HER2治疗中的应用共识

Application consensus of peripheral blood HER2 gene amplification detection (digital PCR) in anti-HER2 therapy

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