2021年胰腺神经内分泌肿瘤诊治的新进展

doi:10.19401/j.cnki.1007-3639.2022.09.003

中国癌症杂志 ›› 2022, Vol. 32 ›› Issue (9): 772-778.doi: 10.19401/j.cnki.1007-3639.2022.09.003

2021年胰腺神经内分泌肿瘤诊治的新进展

高鹤丽(), 徐近(), 虞先濬()

复旦大学附属肿瘤医院胰腺外科，复旦大学上海医学院肿瘤学系，复旦大学胰腺肿瘤研究所，上海市胰腺肿瘤研究所，上海 200032

收稿日期:2022-02-15 修回日期:2022-06-21 出版日期:2022-09-30 发布日期:2022-10-24
通信作者: 徐近,虞先濬
作者简介:高鹤丽（ORCID: 0000-0001-6094-5776）,博士,主治医师。
徐近,主任医师,教授,博士研究生导师。复旦大学附属肿瘤医院胰腺外科主任,上海市抗癌协会神经内分泌肿瘤专业委员会主任委员,中国抗癌协会青年理事会理事,中国抗癌协会胰腺癌专业委员会青委会副主任委员。长期致力于改进胰肠吻合降低胰瘘发生的研究、胰腺癌个体化精准治疗的研究及胰腺神经内分泌肿瘤的综合治疗研究。获得4项国家自然科学基金及多项上海市级课题,以第一或通信讯作者在SCI收录期刊上发表论文30余篇,并荣获上海市职工优秀创新成果一等奖、上海市优秀发明金奖、上海市医学科技奖三等奖。
虞先濬,主任医师,教授,博士研究生导师,复旦大学附属肿瘤医院副院长,上海市胰腺肿瘤研究所所长,复旦大学胰腺肿瘤研究所所长。国家杰出青年科学基金获得者,国家科技部“中青年科技创新领军人才”,国家百千万人才工程“有突出贡献中青年专家”,全国五一劳动奖章获得者,上海市领军人才,上海工匠,复旦大学首届“名医工程”入选者,中国抗癌协会胰腺癌专业委员会候任主任委员,中国胰腺癌多学科协作组组长,中华医学会外科学分会胰腺外科学组委员,中国医师协会胰腺病专业委员会委员,中国临床肿瘤学会胰腺癌专家委员会常务委员,美国外科医师学会会员。主持国家自然基金中德国际重点合作项目1项、国家自然科学基金面上项目3项、省部级项目12项,总计获得科研经费3 000余万元。以通信作者在Journal of Clinical Oncology、Gut、Annals of Surgery、Cell Research、Autophagy、Clinical Cancer Research、Cancer Research等国际权威SCI收录期刊上发表论文200余篇。

Updates on the research and management of pancreatic neuroendocrine neoplasm in 2021

GAO Heli(), XU Jin(), YU Xianjun()

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Pancreatic Cancer Institute, Fudan University; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China

Received:2022-02-15 Revised:2022-06-21 Published:2022-09-30 Online:2022-10-24
Contact: XU Jin, YU Xianjun

摘要/Abstract

摘要：

胰腺神经内分泌肿瘤（pancreatic neuroendocrine neoplasm,PanNEN）发病率低且异质性强,有关PanNEN分子机制的研究逐渐增多,同时PanNEN临床诊断、治疗和预后预测也有新的进展。指南除常规推荐手术、介入治疗等局部治疗,以及生长抑素类似物、靶向治疗等系统治疗外,还存在一些手术问题和药物应用的争议,这些问题和争议也体现了PanNEN诊治过程中的个体化原则和全程管理。本文对2021年PanNEN基础和临床方面的研究进展进行综述。

关键词: 胰腺神经内分泌肿瘤, 分子标志物, 诊断, 预后, 治疗

Abstract:

Pancreatic neuroendocrine neoplasm (PanNEN) has a low incidence and strong heterogeneity. Research on molecular mechanism of PanNEN is gradually increasing. At the same time, the updates on clinical diagnosis, treatment and prognosis prediction of PanNEN patients are increasing. In addition to surgery and systemic treatment such as somatostatin analogs and tyrosine kinase inhibitors, there are unsolved problems and questions in the management of PanNEN patients, which emphasizes individualized treatment and multidisciplinary treatment. This article summarized the basic and clinical research progress of PanNEN in 2021.

Key words: Pancreatic neuroendocrine tumor, Molecular marker, Diagnosis, Prognosis, Treatment

中图分类号:

R735.9

高鹤丽, 徐近, 虞先濬. 2021年胰腺神经内分泌肿瘤诊治的新进展[J]. 中国癌症杂志, 2022, 32(9): 772-778.

GAO Heli, XU Jin, YU Xianjun. Updates on the research and management of pancreatic neuroendocrine neoplasm in 2021[J]. China Oncology, 2022, 32(9): 772-778.

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2021年胰腺神经内分泌肿瘤诊治的新进展

Updates on the research and management of pancreatic neuroendocrine neoplasm in 2021

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