2021年胰腺神经内分泌肿瘤诊治的新进展

doi:10.19401/j.cnki.1007-3639.2022.09.003

摘要/Abstract

摘要：

胰腺神经内分泌肿瘤（pancreatic neuroendocrine neoplasm,PanNEN）发病率低且异质性强,有关PanNEN分子机制的研究逐渐增多,同时PanNEN临床诊断、治疗和预后预测也有新的进展。指南除常规推荐手术、介入治疗等局部治疗,以及生长抑素类似物、靶向治疗等系统治疗外,还存在一些手术问题和药物应用的争议,这些问题和争议也体现了PanNEN诊治过程中的个体化原则和全程管理。本文对2021年PanNEN基础和临床方面的研究进展进行综述。

关键词: 胰腺神经内分泌肿瘤, 分子标志物, 诊断, 预后, 治疗

Abstract:

Pancreatic neuroendocrine neoplasm (PanNEN) has a low incidence and strong heterogeneity. Research on molecular mechanism of PanNEN is gradually increasing. At the same time, the updates on clinical diagnosis, treatment and prognosis prediction of PanNEN patients are increasing. In addition to surgery and systemic treatment such as somatostatin analogs and tyrosine kinase inhibitors, there are unsolved problems and questions in the management of PanNEN patients, which emphasizes individualized treatment and multidisciplinary treatment. This article summarized the basic and clinical research progress of PanNEN in 2021.

Key words: Pancreatic neuroendocrine tumor, Molecular marker, Diagnosis, Prognosis, Treatment

中图分类号:

R735.9

高鹤丽, 徐近, 虞先濬. 2021年胰腺神经内分泌肿瘤诊治的新进展[J]. 中国癌症杂志, 2022, 32(9): 772-778.

GAO Heli, XU Jin, YU Xianjun. Updates on the research and management of pancreatic neuroendocrine neoplasm in 2021[J]. China Oncology, 2022, 32(9): 772-778.

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