基于文献计量学的国内外肿瘤心脏病学研究现状与热点分析

doi:10.19401/j.cnki.1007-3639.2022.10.001

摘要/Abstract

摘要：

背景与目的：肿瘤心脏病学作为一门新兴的交叉学科，主要关注与肿瘤治疗相关的心血管毒性的管理，在过去十年取得了长足的发展。本研究利用文献计量学方法分析国内外肿瘤心脏病学领域热点和趋势，为相关研究提供参考。方法：基于Web of Science核心数据库和中国知网即中国知识基础设施工程（China National Knowledge Infrastructure，CNKI），使用CiteSpace软件对2012—2022年国内外肿瘤心脏病学领域研究的发文量、国家、机构、作者、高被引文献、关键词进行分析。结果：筛选后共纳入4 287篇英文文献，1 165篇中文文献。目前国外肿瘤心脏病学领域的文献数量呈快速增长趋势，而中国以2016年为界，产生了“缓慢发展期”和“快速发展期”。美国是Web of Science中发文量最多的国家，约占总数的34.21%，其次是中国、意大利等。国内外发文量最多的机构分别是得克萨斯大学MD安德森癌症中心（The University of Texas MD Anderson Cancer Center）和大连医科大学附属第一医院。国外以Bonnie KY、Ana Barac、Paaladinesh Thavendiranathan等为主要贡献者，国内以夏云龙、张宇辉、程蕾蕾等为主要贡献者。Web of Science被引频次最高的文献是来自欧洲心脏病学会的关于癌症治疗和心血管毒性的立场声明，反映了专业协会的指南和共识常作为一个学科中被广泛引用的文献可直接影响临床实践。国外出现频次最高的关键词是“heart failure”、“breast cancer”、“cardiotoxicity”等，国内出现频次最高的关键词是“心脏毒性”、“心脏肿瘤”、“阿霉素”等。“immune checkpoint inhibitors”、“免疫检查点抑制剂相关心肌炎”是近3年的突现词，从分析结果可以看出，国外主要关注肿瘤心脏病的发生机制、肿瘤心脏病的防治，国内则更多地关注抗肿瘤治疗引起的心脏毒性，如“化疗”、“阿霉素”、“多柔比星”、“蒽环类”等。 结论：研究热点主要集中于抗肿瘤治疗引起的心脏毒性、肿瘤心脏病的防治、肿瘤心脏病的筛查与诊断等；建立多学科参与的诊疗模式，关注免疫检查点抑制剂相关心肌炎及肿瘤心脏病的全程管理是未来关注的方向。

关键词: 肿瘤心脏病学, 心脏毒性, 文献计量学, CiteSpace

Abstract: Background and objective: Cardio-oncology that focuses on the management of cardiovascular toxicity associated with cancer therapy, has grown rapidly worldwide as an emerging interdisciplinary discipline over the past decade. This study aimed to summarize the hot spots and development trends of cardio-oncology to provide a reference for scientific researchers in related fields based on bibliometrics. Methods: CiteSpace was employed to conduct the visualized analysis of annual publications, authors, countries, citations and keywords of the related papers from 2012 to 2022 in the Web of Science Core Collection and China National Knowledge Infrastructure (CNKI). Results: A total of 4 287 English articles and 1 165 Chinese articles were included after screening. At present, the number of foreign literature in the field of cardio-oncology, showed a trend of rapid growth, while our country has "slow development period" and "rapid development period" with 2016 as the boundary. The United States is the country with the largest number of publications in Web of Science, accounting for about 34.21% of the total, followed by China, Italy and other countries. The institutions with the largest number of publications at home and abroad are the University of Texas MD Anderson Cancer Center and the First Affiliated Hospital of Dalian Medical University. Bonnie KY, Ana Barac, Paaladinesh Thavendiranathan are the main contributors abroad, and Xia Yunlong, Zhang Yuhui and Cheng Leilei are the main contributors in China. The most frequently cited literature is the position statement on cancer treatment and cardiovascular toxicity from the European Society of Cardiology. The most frequently used keywords abroad were "heart failure", "breast cancer" and "cardiotoxicity", while the most frequently used keywords in China were "cardiotoxicity", "cardiac tumor" and "doxorubicin". Keywords with the strongest citation bursts at home and abroad in recent three years are "immune checkpoint inhibitors". Conclusion: The research hotspots mainly focus on cardiotoxicity caused by antineoplastic therapy, prevention and treatment, screening and diagnosis of cardiovascular toxicity associated with cancer therapy, etc. Establishing a multidisciplinary diagnosis and treatment model and paying attention to the immune checkpoint inhibitor-related myocarditis and whole process management of cardio-oncology are the directions of future development.

Key words: Cardio-oncology, Cardiotoxicity, Bibliometrics, CiteSpace

中图分类号:

R737

李孟娟, 刘莹, 张艳丽, 刘萌垚, 薛亚男, 苏丽萍, 张秀杰, 史铁英, 方凤奇, 刘基巍, 夏云龙. 基于文献计量学的国内外肿瘤心脏病学研究现状与热点分析[J]. 中国癌症杂志, 2022, 32(10): 925-935.

LI Mengjuan, LIU Ying, ZHANG Yanli, LIU Mengyao, XUE Yanan, SU Liping, ZHANG Xiujie, SHI Tieying, FANG Fengqi, LIU Jiwei, XIA Yunlong. Current status and research hotspots of cardio-oncology based on bibliometrics[J]. China Oncology, 2022, 32(10): 925-935.

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Country	Centrality	Article n
USA	0.31	1 467
China	0.04	651
Italy	0.05	466
Canada	0.11	279
UK	0.13	238
Germany	0.03	203
Japan	0.01	152
Netherlands	0.04	152
Australia	0.11	136
France	0.16	135

No.	WOS		CNKI
No.	Institution	Article n	Institution	Article n
1	The University of Texas MD Anderson Cancer Center	119	Department of Cardiology, First Affiliated Hospital of Dalian Medical University	26
2	University of Pennsylvania	102	Department of Oncology, First Affiliated Hospital of Dalian Medical University	16
3	Mayo Clinic	97	Department of Ultrasound, The First Affiliated Hospital of Anhui Medical University	12
4	Memorial Sloan-Kettering Cancer Center	85	Heart Failure Center, National Center for Cardiovascular Diseases and Fuwai Hospital, CAMS and PUMC	11
5	University of Toronto	81	Shanghai Institute of Cardiovascular Diseases	9
6	Harvard Medical School	79	Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute	8
7	University of Naples Federico Ⅱ	64	Department of Intracardiac, Harbin Medical University Cancer Hospital	8
8	Vanderbilt University	60	Department of Radiotherapy, the Fourth Hospital of Hebei Medical University	8
9	Duke University	57	Tianjin University of Traditional Chinese Medicine	8
10	Massachusetts General Hospital	52	Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine	4

No.	WOS		CNKI
No.	Co-occurrence	Keyword	Co-occurrence	Keyword
1	1 043	Heart failure	230	Cardiotoxicity
2	888	Breast cancer	88	Cardiac tumor
3	746	Cardiotoxicity	82	Breast cancer
4	561	Chemotherapy	57	Adriamycin
5	555	Therapy	42	Chemotherapy
6	454	Oxidative stress	38	Tumour
7	390	Doxorubicin	35	Ventricular function
8	337	Risk	31	Doxorubicin
9	335	Cancer	30	Heart failure
10	290	American Society	30	Anthracycline
11	283	Cardiovascular disease	27	Hypertension
12	279	Cardiac dysfunction	25	Adverse reaction
13	273	Congestive heart failure	24	Myocarditis
14	264	Mechanism	22	Cardiac injury
15	243	Echocardiography	20	Lymphoma
16	209	Apoptosis	19	Malignant tumor
17	206	Childhood cancer	19	Radiation therapy
18	200	Management	17	Ultrasonography
19	200	Cardiomyopathy	16	Thoracic tumor
20	192	Prevention	16	Dexrazoxane

Keyword	Strength	Begin	End
Daunorubicin	5.12	2012	2015
Radiation therapy	3.56	2012	2016
Dexrazoxane	3.28	2012	2017
Children	2.49	2012	2014
Epirubicin	2.48	2013	2014
Thoracic tumor	5.38	2014	2016
Cardiogram	2.90	2018	2020
Chemotherapy	2.63	2018	2019
Myocarditis	5.29	2019	2022
Lung cancer	4.34	2019	2020