2022年度胰腺癌研究及诊疗新进展

doi:10.19401/j.cnki.1007-3639.2023.01.001

摘要/Abstract

摘要：

胰腺癌是中国致死人数排名第六的恶性肿瘤，其恶性程度高，早期病情隐匿，超过80%的患者在就诊时已进展为晚期，错失手术切除治愈的机会；而成功接受了手术治疗的胰腺癌患者，也极易发生转移，5年生存率仅为15% ~ 20%。不同于其他癌种，胰腺癌的放化疗及免疫治疗效率均较低，分子分型和精准治疗技术的研究也相对落后，急需临床医疗资源的投入和优质科研成果的转化，以改善患者预后。2022年是胰腺癌转化研究领域厚积薄发的一年，见证了第1个靶向KRAS^G12D的小分子药物的诞生和个性化T细胞受体工程化T（T-cell receptor engineered T，TCR-T）细胞治疗技术的临床应用，在胰腺癌发病因素、分子机制、代谢、免疫微环境等基础领域，以及早期诊断、手术治疗、药物治疗、免疫治疗等临床领域也各自取得了新突破。本文对2022年胰腺癌研究和诊疗领域的最新进展进行综述。

关键词: 胰腺癌, 基础研究, 临床研究

Abstract:

Pancreatic cancer is the sixth leading cause of cancer-related death in China. It is characterized by high malignancy and concealment at early stages. More than 80% of patients have progressed to advanced stages at the time of diagnosis, and missed the opportunity of surgical resection. Pancreatic cancer patients who have successfully received surgical resection are at a high risk of metastasis, and the 5-year survival rate is only 15%-20%. Unlike other types of cancer, radiotherapy, chemotherapy and immunotherapy do not work well for pancreatic cancer, and the research in molecular subtyping and precision medical therapy technology is also slow. It is an urgent need to devote more clinical medical resources and transfer high-quality scientific research achievements to improve the prognosis of patients. The year 2022 is a year of profound accumulation in the field of translational pancreatic cancer research, witnessing the generation of the first small-molecule drug targeting KRAS^G12D and the clinical application of personalized T-cell receptor engineered T (TCR-T) cell therapy, as well as other advances in basic fields such as pathogenesis, molecular mechanism, metabolic immune microenvironment, and clinical fields such as early diagnosis, surgical treatment, radiation therapy, chemotherapy and immunotherapy. Here we reviewed the latest progress in research, diagnosis and treatment of pancreatic cancer in 2022.

Key words: Pancreatic cancer, Basic research, Clinical research

中图分类号:

R735.9

王旭, 程合, 刘辰, 虞先濬. 2022年度胰腺癌研究及诊疗新进展[J]. 中国癌症杂志, 2023, 33(1): 1-13.

WANG Xu, CHENG He, LIU Chen, YU Xianjun. New progress in basic research, clinical diagnosis and treatment of pancreatic cancer in 2022[J]. China Oncology, 2023, 33(1): 1-13.

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