中国癌症杂志 ›› 2023, Vol. 33 ›› Issue (1): 1-13.doi: 10.19401/j.cnki.1007-3639.2023.01.001
收稿日期:
2022-12-30
修回日期:
2023-01-13
出版日期:
2023-01-30
发布日期:
2023-02-13
通信作者:
虞先濬(ORCID: 0000-0002-6697-7143),博士,教授、主任医师,复旦大学附属肿瘤医院副院长。
作者简介:
王旭(ORCID: 0000-0001-6920-0375),博士,副研究员。基金资助:
WANG Xu(), CHENG He, LIU Chen, YU Xianjun()
Received:
2022-12-30
Revised:
2023-01-13
Published:
2023-01-30
Online:
2023-02-13
Contact:
YU Xianjun
摘要:
胰腺癌是中国致死人数排名第六的恶性肿瘤,其恶性程度高,早期病情隐匿,超过80%的患者在就诊时已进展为晚期,错失手术切除治愈的机会;而成功接受了手术治疗的胰腺癌患者,也极易发生转移,5年生存率仅为15% ~ 20%。不同于其他癌种,胰腺癌的放化疗及免疫治疗效率均较低,分子分型和精准治疗技术的研究也相对落后,急需临床医疗资源的投入和优质科研成果的转化,以改善患者预后。2022年是胰腺癌转化研究领域厚积薄发的一年,见证了第1个靶向KRASG12D的小分子药物的诞生和个性化T细胞受体工程化T(T-cell receptor engineered T,TCR-T)细胞治疗技术的临床应用,在胰腺癌发病因素、分子机制、代谢、免疫微环境等基础领域,以及早期诊断、手术治疗、药物治疗、免疫治疗等临床领域也各自取得了新突破。本文对2022年胰腺癌研究和诊疗领域的最新进展进行综述。
中图分类号:
王旭, 程合, 刘辰, 虞先濬. 2022年度胰腺癌研究及诊疗新进展[J]. 中国癌症杂志, 2023, 33(1): 1-13.
WANG Xu, CHENG He, LIU Chen, YU Xianjun. New progress in basic research, clinical diagnosis and treatment of pancreatic cancer in 2022[J]. China Oncology, 2023, 33(1): 1-13.
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