胰腺神经内分泌瘤的精准诊疗进展

doi:10.19401/j.cnki.1007-3639.2023.11.004

中国癌症杂志 ›› 2023, Vol. 33 ›› Issue (11): 993-1001.doi: 10.19401/j.cnki.1007-3639.2023.11.004

胰腺神经内分泌瘤的精准诊疗进展

高鹤丽¹(), 徐近¹, 陈洁²(), 虞先濬¹()

1.复旦大学附属肿瘤医院胰腺外科，复旦大学上海医学院肿瘤学系，复旦大学胰腺肿瘤研究所，上海市胰腺肿瘤研究所，上海 200032
2.复旦大学附属肿瘤医院神经内分泌肿瘤中心，头颈及神经内分泌肿瘤内科，复旦大学上海医学院肿瘤学系，上海 200032

收稿日期:2023-07-18 修回日期:2023-10-30 出版日期:2023-11-30 发布日期:2023-12-14
通信作者: 虞先濬（ORCID: 0000-0002-1042-3694），博士，主任医师，复旦大学附属肿瘤医院院长；陈洁（ORCID：0000-0001-8113-3515)，博士，主任医师，复旦大学附属肿瘤医院神经内分泌肿瘤中心主任。
作者简介:高鹤丽（ORCID: 0000-0001-6094-5776），博士，主治医师。
陈洁，主任医师，教授，博士研究生导师。现任复旦大学附属肿瘤医院神经内分泌肿瘤多学科首席专家，复旦大学附属肿瘤医院神经内分泌肿瘤中心主任，复旦大学附属肿瘤医院头颈及神经内分泌肿瘤内科主任。担任欧洲神经内分泌肿瘤学会顾问委员会委员，欧洲肿瘤内科学会神经内分泌及内分泌肿瘤学组委员，国际神经内分泌肿瘤联盟医疗顾问委员会委员，中国抗癌协会神经内分泌肿瘤专业委员会主任委员，中国抗癌协会胰腺癌专业委员会神经内分泌肿瘤学组组长，中国抗癌协会肿瘤内分泌专业委员会副主任委员，中华医学会消化病学分会胃肠激素与神经内分泌肿瘤学组副组长，中国医师协会胰腺病专业委员会胰腺神经内分泌肿瘤专业委员会副主任委员，中国临床肿瘤学会罕见肿瘤专家委员会委员，中国抗癌协会理事，上海市抗癌协会常务理事。欧洲神经内分泌肿瘤学会官方杂志Journal of Neuroendocrinology高级编委，Journal of Pancreatology编委，《中国癌症杂志》编委。
虞先濬，主任医师，二级教授，博士研究生导师。现任复旦大学附属肿瘤医院院长，上海市胰腺肿瘤研究所所长，复旦大学胰腺肿瘤研究所所长。国家杰出青年科学基金获得者，国家科技部“中青年科技创新领军人才”，国家百千万人才工程“有突出贡献中青年专家”，全国五一劳动奖章获得者，上海市领军人才，上海工匠，上海市科技精英。享受国务院政府特殊津贴。担任中国抗癌协会胰腺癌专业委员会主任委员，中国胰腺癌多学科协作组组长，中华医学会外科学分会胰腺外科学组委员，中国医师协会胰腺病专业委员会委员，中国临床肿瘤学会胰腺癌专家委员会常务委员等职务。
基金资助:
国家自然科学基金“罕见肿瘤研究专项”项目(82141104)

Updates on precision medicine of pancreatic neuroendocrine tumor

GAO Heli¹(), XU Jin¹, CHEN Jie²(), YU Xianjun¹()

1. Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Pancreatic Cancer Institute, Fudan University, Shanghai Pancreatic Cancer Institute, Shanghai 200032, China
2. Center for Neuroendocrine Tumors, Department of Head, Neck and Neuroendocrine Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Received:2023-07-18 Revised:2023-10-30 Published:2023-11-30 Online:2023-12-14

摘要/Abstract

摘要：

自2011年肿瘤精准医疗的概念提出后，实体肿瘤的治疗逐渐迈入以基因检测和靶向治疗为主导的精准医学时代。作为少见肿瘤，胰腺神经内分泌瘤（pancreatic neuroendocrine tumor，PanNET）的发病率逐年升高，既往以分期、分级、分化为基础的临床病理学因素作为PanNET治疗选择和预后预测的指标，没有精准标志物用于判断PanNET预后及指导其治疗药物的选择。随着临床医师对PanNET的诊断、治疗和预后预测等方面的认识更新，以及基因组学和分子检测在PanNET中的深入研究，精准医疗能否给PanNET的诊治和预后预测带来新的变革?本文通过回顾最新文献阐述PanNET精准诊疗现状。

关键词: 胰腺神经内分泌肿瘤, 精准医疗, 预后预测, 靶向治疗

Abstract:

Since the concept of precision medicine proposed in 2011, the treatment of solid tumors has entered era of precision medicine led by gene testing. As a rare tumor, the incidence rate of pancreatic neuroendocrine tumor (PanNET) is increasing gradually. In the past, clinicopathological factors such as stage and grade system were used as criteria in the diagnosis and prognostic prediction of PanNET patients, and there were few biomarkers guiding the selection of PanNET diagnosis and treatment. As the diagnosis, treatment and prognosis of PanNET have been updated these years, and genomics and molecular testing are wildly used in PanNET research, can precision bring new changes to the diagnosis, treatment and prognostic prediction of PanNET? This article reviewed the current status of PanNET precision therapy through the latest literature.

Key words: Pancreatic neuroendocrine neoplasm, Precision medicine, Prognostic prediction, Target therapy

中图分类号:

R735.9

高鹤丽, 徐近, 陈洁, 虞先濬. 胰腺神经内分泌瘤的精准诊疗进展[J]. 中国癌症杂志, 2023, 33(11): 993-1001.

GAO Heli, XU Jin, CHEN Jie, YU Xianjun. Updates on precision medicine of pancreatic neuroendocrine tumor[J]. China Oncology, 2023, 33(11): 993-1001.

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胰腺神经内分泌瘤的精准诊疗进展

Updates on precision medicine of pancreatic neuroendocrine tumor

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