关键词: 造血干细胞移植, 脐血, 恶性血液肿瘤

Abstract:

Allogeneic hematopoietic stem cell transplantation is the only treatment method to cure hematologic malignancies. However, difficulty in obtaining the human leukocyte antigen (HLA) match donors is a major limitation in this therapeutic strategy. Many studies have demonstrated that umbilical cord blood is rich in hematopoietic stem cells and can be used as a source of stem cells of hematopoietic stem cell transplantation. Growing evidence also supports the efficacy of cord blood transplantation (CBT) to treat patients with haematological malignancies, and the number of CBTs is rapidly increasing. Compared to other sources of stem cells, umbilical cord blood is physical cryopreserved. Therefore, it is very convenient for transplantation, particular for those who need to receive transplantation sooner. In addition, the incidence and severity of graft versus host disease(GVHD) in CBT are usually relatively lower. Herein, we review considerations regarding status, research progresses and selection of umbilical cord blood in CBT.

Key words: Hematopoietic stem cell transplantation, Umbilical cord blood, Hematologic malignancies