中国癌症杂志 ›› 2014, Vol. 24 ›› Issue (10): 745-749.doi: 10.3969/j.issn.1007-3969.2014.10.005

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 “双打击”B细胞淋巴瘤的研究进展

郭晔   

  1. 复旦大学附属肿瘤医院肿瘤内科,复旦大学上海医学院肿瘤学系,上海 200032
  • 出版日期:2014-10-30 发布日期:2014-11-12
  • 通信作者: 郭晔 E-mail:pattrick_guo@msn.com
  • 作者简介:郭晔,副主任医师,硕士生导师,复旦大学附属肿瘤医院肿瘤内科副主任,中国抗癌协会肿瘤化疗专业委员会青委会副主任委员,中国抗癌协会临床肿瘤学协会青委会副主任委员,中国抗癌协会临床肿瘤学协会甲状腺癌专委会副主任委员,中国抗癌协会头颈肿瘤专业委员会委员,中国抗癌协会淋巴瘤专业委员会青委会委员,上海市抗癌协会头颈肿瘤专业委员会副主任委员,上海市抗癌协会淋巴瘤专业委员会秘书长。擅长头颈部肿瘤、淋巴瘤以及软组织肉瘤的内科治疗。迄今已在《中华肿瘤杂志》、Oral Oncology、American Journal of Hematology以及Radiation Oncology等国内外杂志发表多篇中、英文论文,参编书籍数部。

The research progress on double-hit lymphoma

GUO Ye   

  1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Published:2014-10-30 Online:2014-11-12
  • Contact: GUO Ye E-mail: pattrick_guo@msn.com

摘要:

“双打击”B细胞淋巴瘤(double-hit lymphomaDHL)是一种近年来被确认的B细胞淋巴瘤分子分型,主要涉及MYCBcl-2基因的重排。荧光原位杂交(fluorescence in situ hybridizationFISH)是诊断DHL的金标准,而通过免疫组化检测MYCBcl-2蛋白的表达仍存在一定的争议。大量的回顾性分析表明,DHL是一种预后很差的独特类型,主要发生于弥漫大B细胞淋巴瘤或灰区淋巴瘤,且目前缺乏标准的治疗方案。无论是利妥昔单抗的联合抑或干细胞移植似乎均不能显著逆转DHL的不良预后,其治疗的改善应依赖于探索特异性的分子靶向药物

关键词: &ldquo, 双打击&rdquo, B细胞淋巴瘤, 诊断, 治疗, 预后

Abstract:

Recently, double-hit lymphoma (DHL) was clarified to be a molecular category of B-cell lymphoma, which was mainly related to MYC and Bcl-2 genes translocation. Fluorescence in situ hybridization (FISH) is the gold standard of diagnosis and it is controversial to detect the expression of MYC and Bcl-2 protein by immunohistochemistry. DHL, which was found to be aggressive according to many retrospective analyses, mainly develops in patients with diffuse large B-cell lymphoma and grey zone lymphoma. Both rituximab combination and transplant consolidation were not able to significantly overcome the poor prognosis of DHL. Novel and specific molecular targeted agents need to be explored and investigated in order to improve the treatment outcome.

Key words: Double-hit lymphoma, Diagnosis, Treatment, Prognosis