中国癌症杂志 ›› 2014, Vol. 24 ›› Issue (12): 944-950.doi: 10.3969/j.issn.1007-3969.2014.12.011

• 论著 • 上一篇    下一篇

不同组织模式下乳腺癌筛查结果分析

李毅 吕艳丽 赵越 秦红风 杨春霞 王雅伶   

  1. 北京市顺义区妇幼保健院乳腺中心,北京 101300
  • 出版日期:2014-12-30 发布日期:2015-05-07
  • 通信作者: 李毅 E-mail:liyiborui@126.com

Preliminary analysis of different organization models of breast cancer screening

LI Yi, LV Yan-Li, ZHAO Yue, QIN Hong-feng, YANG Chun-xia, WANG Ya-ling   

  1. Breast Center, Shunyi Health Care Hospital for Women and Children, Beijing 101300, China
  • Published:2014-12-30 Online:2015-05-07
  • Contact: LI Yi E-mail: liyiborui@126.com

摘要: 背景与目的:近年来我国政府对乳腺癌筛查非常重视。本研究分析北京市顺义区乳腺专科和非乳腺专科医疗机构完成的3轮乳腺癌筛查结果,为公共卫生行政部门调整乳腺癌筛查组织模式提供科学依据。方法:乳腺癌普通筛查包括乳腺临床检查和乳腺超声检查,对于高危人群和普通筛查发现的可疑人员转诊至诊断单位行乳腺X线检查及后续诊断和治疗。顺义区乳腺癌筛查的组织模式分为2种,即顺义区妇幼保健院乳腺中心的专科组织模式和其他单位的非专科组织模式。采用非条件Logistic回归模型,对不同组织模式的乳腺癌检出率和间期癌发生率进行分析。结果:3轮筛查分别完成58 151、57 810和69 849例,检出乳腺癌25、10和30例,粗检出率为42.99/10万、17.30/10万和42.95/10万。第2轮和第3轮筛查中,专科模式的乳腺癌检出率是非专科模式的1.66和1.88倍(P均>0.05)。第2轮和第3轮筛查非专科模式乳腺间期癌的发生率均高于专科模式(65.94/10万 vs 31.20/10万,66.17/10万 vs 0),其中第2轮非专科模式间期癌的发生率是专科模式的2.47倍(P>0.05)。结论:不同筛查组织模式之间无论是乳腺癌的检出率还是间期癌的发生率均差异较大,差异无统计学意义可能与专科组织模式样本量尚不够大有关。本研究结果提示,大规模乳腺癌筛查以乳腺专科为主导的组织模式可能更有意义。

关键词: 乳腺癌, 乳腺超声检查, 乳腺X线检查, 筛查, 间期癌

Abstract: Background and purpose: In recent years, the government of our country attaches importance to the breast cancer screening. This study aimed to provide scientific basis for improving breast cancer screening policy, the results of breast specialized model and non-breast specialized model screening program in Shunyi District in Beijing were analyzed. Methods: The general screening item contains breast clinical examination and breast ultrasonography. The person who had family history or was defined high-risk population in general screening would be sent to diagnostic unit for mammography and further therapy if needed. There were two different breast cancer screening organization models in Shunyi district, named breast specialized model and non-breast specialized model, respectively. The associations between organization models and detection rate of breast cancer/incidence rate of breast interval cancer were evaluated by unconditional logistic regression analysis. Results: Overall, 58 151, 57 810 and 69 849 participants were invited in 3 round breast cancer screening, respectively. A total of 25, 10 and 30 breast cancer cases were detected, and the crude detection rates were 42.99 per 100 000, 17.30 per 100 000, and 42.95 per 100 000, respectively. In the second and third round of screening, compared with non-breast specialized model, breast specialized model can increase the detection rate of breast cancer (P>0.05), and decrease the incidence rate of interval cancer (65.94 per 100 000 vs 31.20 per 100 000, 66.17 per 100 000 vs 0, P>0.05). Conclusion: There did exists huge difference in breast cancer detection and interval cancer incidence rates between breast specialized model and non-breast specialized model. The results haven’t reach statistical significance because of low statistical power, thus, further study with enough sample size in breast specialized model is necessary. Breast cancer screening program based on breast specialized department may be more effective and valuable.

Key words: Breast cancer, Breast ultrasonography, Breast mammography, Screening, Interval cancer