神经内分泌肿瘤药物临床试验进展

doi:10.19401/j.cnki.1007-3639.2022.09.001

中国癌症杂志 ›› 2022, Vol. 32 ›› Issue (9): 757-764.doi: 10.19401/j.cnki.1007-3639.2022.09.001

神经内分泌肿瘤药物临床试验进展

梁贇¹(), 吉顺荣², 虞先濬², 陈洁¹()

1.复旦大学附属肿瘤医院神经内分泌肿瘤中心,头颈及神经内分泌肿瘤内科,复旦大学上海医学院肿瘤学系,上海 200032
2.复旦大学附属肿瘤医院胰腺外科,复旦大学上海医学院肿瘤学系,复旦大学胰腺肿瘤研究所,上海市胰腺肿瘤研究所,上海 200032

收稿日期:2022-07-10 修回日期:2022-09-01 出版日期:2022-09-30 发布日期:2022-10-24
通信作者: 陈洁
作者简介:梁贇（ORCID: 0000-0003-3759-2997）,博士,主治医师。
陈洁,主任医师,教授,博士研究生导师,复旦大学附属肿瘤医院神经内分泌肿瘤多学科首席专家,复旦大学附属肿瘤医院神经内分泌肿瘤中心主任,头颈及神经内分泌肿瘤内科主任。欧洲神经内分泌肿瘤学会顾问委员会委员,欧洲肿瘤内科学会神经内分泌及内分泌肿瘤学组委员,国际神经内分泌肿瘤联盟医疗顾问委员会委员,中国抗癌协会神经内分泌肿瘤专业委员会主任委员（筹）,中国抗癌协会胰腺癌专业委员会神经内分泌肿瘤学组组长,中国抗癌协会肿瘤内分泌专业委员会副主任委员,中华医学会消化病学分会胃肠激素与神经内分泌肿瘤学组副组长,中国医师协会胰腺病专业委员会胰腺神经内分泌肿瘤委员会副主任委员,中国医疗保健国际交流促进会神经内分泌肿瘤分会常务委员,中国临床肿瘤学会罕见肿瘤专家委员会委员。欧洲神经内分泌肿瘤学会官方杂志Journal of Neuroendocrinology高级编委,Journal of Pancreatology编委,《中国癌症杂志》编委,《中华消化杂志》通讯编委。长期致力于神经内分泌肿瘤的诊治与研究,发表神经内分泌肿瘤相关论著80余篇,获得国家自然科学基金罕见肿瘤重点专项资助。作为主要执笔人参与中华医学会消化病分会胃肠激素与神经内分泌学组《胃肠胰神经内分泌肿瘤诊治专家共识（2020·广州）》及中华医学会外科学分会胰腺外科学组《中国胰腺神经内分泌肿瘤诊疗指南（2020）》的制订,作为主编牵头中国抗癌协会首版《中国抗癌协会神经内分泌肿瘤诊治指南（2022年版）》的制订。
基金资助:
国家自然科学基金“罕见肿瘤研究专项”项目(82141104)

Updates on medical treatment for neuroendocrine neoplasm

LIANG Yun¹(), JI Shunrong², YU Xianjun², CHEN Jie¹()

1. Center for Neuroendocrine Tumors, Department of Head, Neck and Neuroendocrine Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
2. Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Pancreatic Cancer Institute, Fudan University, Shanghai Pancreatic Cancer Institute, Shanghai 200032, China

Received:2022-07-10 Revised:2022-09-01 Published:2022-09-30 Online:2022-10-24
Contact: CHEN Jie

摘要/Abstract

摘要：

神经内分泌肿瘤（neuroendocrine neoplasm,NEN）是一类起源于神经内分泌细胞及肽能神经元的高度异质性的少见肿瘤。根据细胞分化的程度,NEN可分为分化好的神经内分泌瘤（neuroendocrine tumor,NET）和分化差的神经内分泌癌（neuroendocrine carcinoma,NEC）。药物治疗是进展期NEN患者首选的全身治疗方式。本文总结了近年来在NEN领域的重要药物临床试验进展,为临床治疗提供参考。

关键词: 神经内分泌肿瘤, 药物, 临床试验

Abstract:

Neuroendocrine neoplasm (NEN) is a group of heterogeneous malignancies arising from neuroendocrine cells and peptidergic neurons. According to its cell differentiation, NEN can be divided into two distinct groups as well-differentiated neuroendocrine tumor (NET) and poorly-differentiated neuroendocrine carcinoma (NEC). For advanced NEN, medication is the preferred treatment. In this article, we reviewed current clinical trials in medical treatment for NEN and aimed to provide treatment reference in clinical practice.

Key words: Neuroendocrine neoplasms, Medicine, Clinical trial

中图分类号:

R730.5

梁贇, 吉顺荣, 虞先濬, 陈洁. 神经内分泌肿瘤药物临床试验进展[J]. 中国癌症杂志, 2022, 32(9): 757-764.

LIANG Yun, JI Shunrong, YU Xianjun, CHEN Jie. Updates on medical treatment for neuroendocrine neoplasm[J]. China Oncology, 2022, 32(9): 757-764.

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神经内分泌肿瘤药物临床试验进展

Updates on medical treatment for neuroendocrine neoplasm

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