中国癌症杂志 ›› 2020, Vol. 30 ›› Issue (10): 733-743.doi: 10.19401/j.cnki.1007-3639.2020.10.003

• 专家述评与论著 • 上一篇    下一篇

肺癌靶向治疗新进展及展望

洪少东,张 力   

  1. 中山大学肿瘤防治中心内科,广东 广州 510060
  • 出版日期:2020-10-30 发布日期:2020-11-11
  • 通信作者: 张 力 E-mail: zhangli@sysucc.org.cn

Recent advances and prospect in targeted therapy for lung cancer

HONG Shaodong, ZHANG Li   

  1. Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China

  • Published:2020-10-30 Online:2020-11-11
  • Contact: ZHANG Li E-mail: zhangli@sysucc.org.cn

摘要: 近年来,靶向药物治疗已全面改变了肺癌的诊疗模式,并显著地改善了肺癌患者的生存期和生活质量。药物的更新迭代、靶向治疗模式的优化、耐药机制的探索、新靶点新药物的研发,不断地丰富肺癌靶向治疗的内容。针对驱动基因阳性肺癌的靶向治疗最新进展和未来方向进行综述。

关键词: 肺癌, 驱动基因, 靶向治疗, 耐药

Abstract: During the past years, targeted agents have dramatically changed the diagnosis and treatment paradigm of lung cancer, which also have significantly improved the survival and quality of life for patients with lung cancer. With the innovations of targeted agents, the optimization of modes of targeted treatment, the exploration of mechanisms of drug resistance and the research and development of novel targets and drugs, the context of targeted therapy in lung cancer is largely enriched. In this paper, we discussed the recent advances and future direction of targeted therapy for driver mutation positive lung cancer.

Key words: Lung cancer, Driver gene, Targeted therapy, Drug resistance