2016年上海市子宫颈癌发病和死亡情况与2002—2016年的变化趋势分析

doi:10.19401/j.cnki.1007-3639.2022.06.006

中国癌症杂志 ›› 2022, Vol. 32 ›› Issue (6): 519-526.doi: 10.19401/j.cnki.1007-3639.2022.06.006

2016年上海市子宫颈癌发病和死亡情况与2002—2016年的变化趋势分析

庞怡¹^,^*()(), 吴春晓¹^,^*()(), 顾凯¹()(), 鲍萍萍¹, 王春芳², 施亮¹, 龚杨明¹, 向詠梅¹, 窦剑明¹, 吴梦吟¹, 付晨³, 施燕¹

1.上海市疾病预防控制中心,慢性非传染病与伤害防治所,上海 200336
2.上海市疾病预防控制中心,疾病预防控制信息所,上海 200336
3.上海市疾病预防控制中心,上海 200336

收稿日期:2022-01-24 修回日期:2022-05-04 出版日期:2022-06-30 发布日期:2022-07-21
通信作者: 顾凯 E-mail:pangyi@scdc.sh.cn;wuchunxiao@scdc.sh.cn;gukai@scdc.sh.cn
作者简介:庞怡（ORCID：0000-0001-9252-8977）,硕士,医师,E-mail: pangyi@scdc.sh.cn;
吴春晓（ORCID：0000-0002-7362-6368）,硕士,副主任医师,E-mail: wuchunxiao@scdc.sh.cn
第一联系人：^* 共同第一作者
基金资助:
上海市医学领军人才(2019LJ24);上海市公共卫生体系建设三年行动计划学科建设项目“大数据与人工智能应用”(GWV-10.1-XK05);上海市科技成果转化和产业化项目“上海自然人群和结直肠癌筛查人群多组学生物特征图谱及结直肠癌风险评估研究”(18401933403)

Analysis of current status of cervical cancer incidence and mortality in Shanghai, 2016 and trends of 2002-2016

PANG Yi¹^,^*()(), WU Chunxiao¹^,^*()(), GU Kai¹()(), BAO Pingping¹, WANG Chunfang², SHI Liang¹, GONG Yangming¹, XIANG Yongmei¹, DOU Jianming¹, WU Mengyin¹, FU Chen³, SHI Yan¹

1. Division of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
2. Division of Disease Control and Prevention Information, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
3. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China

Received:2022-01-24 Revised:2022-05-04 Published:2022-06-30 Online:2022-07-21
Contact: GU Kai E-mail:pangyi@scdc.sh.cn;wuchunxiao@scdc.sh.cn;gukai@scdc.sh.cn

摘要/Abstract

摘要：

背景与目的：上海市疾病预防控制中心每年更新上海市恶性肿瘤发病和死亡及其趋势的统计资料。本文分析2016年上海市子宫颈癌发病和死亡的基本情况及其2002—2016年的变化趋势。方法：采用上海市疾病预防控制中心建立的人群基础肿瘤登记管理系统和死因登记系统收集的2002—2016年子宫颈癌发病和死亡资料,按诊断或死亡年份、年龄组分层分析,计算数量、构成比、粗率、年龄别率、年龄标准化率（标化率）等指标,分析子宫颈癌发病和死亡各个维度的数量和率值趋势,标化率应用Joinpoint回归模型计算年度变化百分比分析变化趋势。计算不同诊断年份组合的新发病例的部分诊断特征指标的数量和构成比。应用Segi’s 1960年世界标准人口构成计算标化率。 结果：2016年上海市子宫颈癌新发病例和死亡人数分别为987例和267人,粗发病率为13.53/10万,标化发病率为8.26/10万,粗死亡率为3.66/10万,标化死亡率为1.87/10万。年龄别发病的数量和率值分别在55 ~ 59岁组和45 ~ 49岁组达到高峰。年龄别死亡的数量和率值分别在50 ~ 54岁组和80 ~ 84岁组达到高峰。上海市子宫颈癌的标化发病率在2002—2010年以年均12.51%的增速上升,在2010—2016年则以年均3.12%的增速上升。2002—2016年的标化死亡率以年均4.52%的增速上升。子宫颈癌的病理组织学类型以鳞癌为主,病理学诊断比例和诊断时Ⅰ期比例持续增长。结论：上海市子宫颈癌发病和死亡处于全球较低流行水平,但均在增长,现况和趋势反映了上海户籍人口在相关危险因素、筛查和检测技术应用和诊疗水平发展等方面的变化。加强相关监测和研究有助于调整防治措施,减少负担。

关键词: 子宫颈癌, 发病率, 死亡率, 趋势, 上海

Abstract:

Background and purpose: The Shanghai Municipal Center for Disease Control and Prevention provides annual updates on cancer occurrence and trends in Shanghai. This study aimed to investigate the cervical cancer incidence and mortality in 2016 and their trends from 2002 to 2016 in Shanghai. Methods: Data of new cervical cancer diagnoses and deaths from 2002 to 2016 were obtained from the population-based cancer registry and Vital Statistics System of Shanghai Municipal Center for Disease Control and Prevention. Cervical cancer incidence and mortality stratified by year of diagnosis or death, and age group were analyzed. Number, proportion, crude rate, age-specific rate, age-standardized rate and others were calculated. The number, proportion and rates of common cancers in different groups were also calculated. Trends in number, age-standardized rates and age-specific rates of incidence and death were estimated. Trends in age-standardized rates of incidence and death were estimated by Joinpoint analysis and characterized by the annual percent change (APC). The cases and proportion of selected diagnostic characteristics in different periods of diagnosis years grouped were also calculated. Segi’s 1960 world standard population was used for calculating age-standardized rates of incidence and mortality. Results: The new cervical cancer cases and deaths were 987 and 267 in Shanghai in 2016. The crude rate of incidence was 13.53/105, and the age-standardized rate of incidence was 8.26/105. The crude rate of mortality was 3.66/105, and the age-standardized rate of mortality was 1.87/105. The age-specific number and rate of incidence reached the peak in the age group of 55-59 years and 45-49 years respectively, while those of mortality reached the peak in the age group of 50-54 years and 80-84 years respectively. The standardized incidence rate of cervical cancer increased by an average annual growth of 12.51% from 2002 to 2010 and 3.12% per year from 2010 to 2016 in Shanghai. The standardized mortality rate increased by 4.52% per year from 2002 to 2016. The major histopathological type of cervical cancer was squamous cell carcinoma. The proportions of morphological verification and stage Ⅰwere increasing. Conclusions: In Shanghai, the incidence and mortality of cervical cancer were at a lower level of the world, but they were increasing. The current status and trends reflect Shanghai permanent population changes in risk factors, screening test use, diagnostic practices and treatment advances. Improvement of the surveillance and research on cervical cancer will help to promote more efficient control and prevention strategies and decrease cancer burden.

Key words: Cervical cancer, Incidence, Mortality, Trends, Shanghai

中图分类号:

R73.33

庞怡, 吴春晓, 顾凯, 鲍萍萍, 王春芳, 施亮, 龚杨明, 向詠梅, 窦剑明, 吴梦吟, 付晨, 施燕. 2016年上海市子宫颈癌发病和死亡情况与2002—2016年的变化趋势分析[J]. 中国癌症杂志, 2022, 32(6): 519-526.

PANG Yi, WU Chunxiao, GU Kai, BAO Pingping, WANG Chunfang, SHI Liang, GONG Yangming, XIANG Yongmei, DOU Jianming, WU Mengyin, FU Chen, SHI Yan. Analysis of current status of cervical cancer incidence and mortality in Shanghai, 2016 and trends of 2002-2016[J]. China Oncology, 2022, 32(6): 519-526.

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参考文献 33

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Item	2002—2006		2007—2011		2012—2016
Item	Cases	Percentage/%	Cases	Percentage/%	Cases	Percentage/%
Morphological verification	1 646	85.68	3 108	91.36	4 421	93.19
Histological type
Squamous cell carcinoma	1 162	60.49	2 303	67.70	3 206	67.58
Adenocarcinoma	271	14.11	430	12.64	621	13.09
Others	42	2.19	77	2.26	142	2.99
Unknown	446	23.22	592	17.40	775	16.34
Stage
Ⅰ	547	28.47	1 117	32.83	1 596	33.64
Ⅱ	296	15.41	429	12.61	701	14.78
Ⅲ	109	5.67	132	3.88	174	3.67
Ⅳ	152	7.91	177	5.20	252	5.31
Unknown	817	42.53	1 547	45.47	2 021	42.60

2016年上海市子宫颈癌发病和死亡情况与2002—2016年的变化趋势分析

Analysis of current status of cervical cancer incidence and mortality in Shanghai, 2016 and trends of 2002-2016

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