中国癌症杂志 ›› 2015, Vol. 25 ›› Issue (8): 624-628.doi: 10.3969/j.issn.1007-3969.2015.08.011

• 论著 • 上一篇    下一篇

老年肺癌与中年肺癌手术患者的临床资料对比分析

傅志强1,2,周 琪2,何文新3,王海峰3,姜格宁3   

  1. 1. 上海同济大学医学院临床医学系,上海 200092 ;
    2. 上海市杨浦区市东医院胸外科,上海 200438 ;
    3. 同济大学附属上海市肺科医院胸外科,上海 200433
  • 出版日期:2015-08-30 发布日期:2015-12-14
  • 通信作者: 姜格宁 E-mail:jgnwp@aliyun.com

Comparison of clinical data of lung cancer between elderly and middle-aged patients accepting operations

FU Zhiqiang1,2, ZHOU Qi2, HE Wenxin3, WANG Haifeng3, JIANG Gening3   

  1. 1.Department of Clinical Medicine, School of Medicine, Tongji University, Shanghai 200092, China; 2.Department of Thoracic Surgery, Shanghai Shidong Hospital, Shanghai 200438, China; 3.Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China
  • Published:2015-08-30 Online:2015-12-14
  • Contact: JIANG Gening E-mail: jgnwp@aliyun.com

摘要: 背景与目的:肺癌是目前我国乃至全球发病率和死亡率最高的恶性肿瘤,多数患者在60岁之后发病,因此对老年患者行肺癌手术是临床非常值得关注的问题。本研究探讨上海肺科医院行肺癌切除手术的老年与中年肺癌患者的临床特征、流行病学特点及围手术期的情况,为临床诊疗提供参考。方法:回顾性分析2007年1月—2012年12月在上海市肺科医院胸外科住院并接受手术的1 019例肺癌患者,比较老年组和中年组在性别、病理类型、TNM分期、术中出血量及术后住院天数等方面的差异。结果:两组性别分布差异有统计学意义(P<0.05),和中年组相比,老年组男性比例更高(76.91% vs 52.81%)。在病理类型上,两组均为腺癌最多、鳞癌次之,但病理类型构成比差异有统计学意义(P<0.05),老年组鳞癌的比例较中年组高(37.5% vs 15.6%),腺癌的比例较中年组低(50.7% vs 72.8%)。在临床分期构成比上,老年组病例中Ⅱa、Ⅱb、Ⅲa期的比例高于中年组,中年组病例中Ⅰa、Ⅰb期的比例高于老年组(P<0.05)。老年组患者术中出血量及术后住院天数均高于中年组患者,两组患者的术后平均住院时间差异有统计学意义(P<0.05)。两组伴随疾病差异有统计学意义(P<0.05),老年组伴随疾病的比例高于中年组(58.6% vs 42.3%)。结论:老年肺癌患者男性较多,病理类型以腺癌较多,来院就诊时以中晚期多见,术中出血量、术后住院天数均多于中年肺癌患者。

关键词: 肺癌, 老年, 临床特征

Abstract: Background and purpose: The morbidity and mortality of lung cancer are currently the highest malignant tumor in China and the world. Most onset age of the illness is after 60 years old. Therefore, surgical resection of lung cancer in the elderly is very worthy of concern. This study aimed to investigate the clinical features, epidemic characteristics and conditions in perioperative period between the elderly and middle-aged patients with lung cancer, and provide the reference for clinical treatment. Methods: Totally 1 019 patients with lung cancer who were admitted to the hospital and accepted the operations in department of thoracic surgery in Shanghai Pulmonary Hospital from Jan. 2007 to Dec. 2012 were analysed retrospectively. The clinical data including gender, pathological type, TNM stage, intraoperative amount of bleeding and post-operative length of hospitalization were compared. Results: There was a significant difference in sexual factors between these two groups (P˂0.05), and compared with the middle-aged group, the proportion of male was more higher in the elderly group (76.91% vs 52.81%). Adenocarcinoma was the most common and squamous carcinoma was the next in both two groups. The constituent ratio of the pathlogical type between the elderly group and the middle-aged group was statistically significant (P˂0.05). The squamous carcinoma in the elderly group was higher than that in the middle-aged group (37.5% vs 15.6%). On the contrary, adenocarcinoma was more common in the middle-aged group (72.8% vs 50.7%). StagesⅡa, Ⅱb, and Ⅲa were more common in the elderly group and stagesⅠa, and Ⅰb were the most clinical stage in the middle-aged group. The clinical stage between two groups was statistically significant (P˂0.05).The intraoperative amount of bleeding was higher and the postoperative length of hospitalization was longer in the elderly group, with a significant difference as compared with that in the middle-aged group(P˂0.05). And there was a significant difference in incidence of accompanying diseases between the two groups, compared with the middle-aged group, the proportion of accompanying diseases was more higher in the elderly group(58.6% vs 42.3%). Conclusion: Elderly patients with lung cancer are more common in males, with adenocarcinoma being the most common. The cancer mostly belongs to a medium or advanced stage. Elderly patients have the trend with more amount of bleeding in operation and lengh of stay.

Key words: Lung cancer, The elderly, Clinical characteristic