最新刊期
卷 27 ， 期 8 ， 2017
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- 摘要：Breast cancer is the most common malignant tumor in women. Surgical treatment is one of the important treatment methods. Breast reconstruction following mastectomy can improve patients’ quality of life with acceptable oncological safety. Autologous tissue breast reconstruction has become an important way owing to its specific advantages. The ideal tissue for autologous breast reconstruction is free abdominal flap. This review presented the clinical application, timing of operation and complications of breast reconstruction with free abdominal flap.关键词：Breast cancer;Breast reconstruction;Free abdominal flap2|1848|0更新时间：2025-12-31
- 摘要：Surgery is one of the most important treatments for breast cancer. A part of the early breast cancer patients demand further oncoplastic breast surgery to reconstruct or restore the breast cosmosis after conventional breast conserving surgery, by oncoplastic breast surgery, which is a modern conception and technique including volume displacement and volume replacement. Oncoplastic breast surgery using pedicled omental flap is a new approach among volume replacement techniques. It has made some progress in recently years. A systematic review was therefore conducted to analyze and illuminate the present status.关键词：Breast cancer;Breast conserving surgery;Oncoplastic breast surgery;Pedicled omental flap;Laparoscopy2|1901|0更新时间：2025-12-31
- 摘要：With the development of breast cancer treatment mode and the changing attitudes of patients, reconstruction of the breast after mastectomy plays an important role in the interdisciplinary treatment concept of breast cancer. Because of the large area and the less variation of vessels pedicle of latissimus dorsi, it is considered to be an alternative flap for breast reconstruction. The latissimus dorsi flap can be used widely in breast reconstruction. Besides the implant-assisted latissimus dorsi (LDI) and autologous latissimus dorsi (ALD) flap breast reconstructions, the modified latissimus dorsi flap could be selected for various mastectomy. Compared with implant-assisted breast reconstruction, the latissimus dorsi flap can model a better mammary contour and receive better cosmetic outcomes on post-reconstruc- tion radiation. Compared with the transverse rectus abdominis myocutaneous (TRAM) flap, the latissimus dorsi flap has smaller scars and more rapid recovery. The improvement in postoperative donor area suturing techniques and auxiliary drug application greatly reduced the incidence of seroma. The Endoscopic technology avoids the donor scar. In clinical practice, statistical evaluation of aesthetic outcomes was impossible as an advantage in operation selection. This article summarized the control of complications and the further discussion of controversy.关键词：Latissimus dorsi myocutaneous flap;Breast reconstruction;Breast cancer2|4215|0更新时间：2025-12-31
- 摘要：With the improving of people’s living quality and medical technology, the demand for breast reconstruction after mastectomy is increasing. Transverse rectus abdominis muscle (TRAM) surgery is an important way of autologous tissue breast reconstruction. This article introduced the anatomy and blood supply of TRAM flap, the indications and contraindications of TRAM surgery, procedure and complications of the surgery. This article also discussed some problems in surgery. TRAM reconstruction, as a way of autologous tissue reconstruction, can avoid the implant related complications because the implant is not used in the surgery. In addition, compared to the implant recon-struction, the appearance and softness of autologous tissue reconstruction are closer to natural breasts, and the result of this surgery is better. In the meantime, pedicled TRAM reconstruction, which does not need microvascular anastomosis technique and close postoperative monitoring of the flap, is easy to be mastered by surgeons and could be performed at more medical centers. Therefore, the TRAM flap still has its own application prospect.关键词：Transverse rectus abdominis muscle flap;Breast cancer;Mastectomy;Breast reconstruction2|3963|0更新时间：2025-12-31
- 摘要：Comparing with free perforator flap, pedicled flap is a relatively simpler and safer technique, with lesser donor site morbidity. In recent years, the application of pedicled perforator flaps has emerged as a new option for breast reconstruction. Those pedicled perforator flaps include thoracodorsal artery perforator flap, intercostal artery perforator flap (lateral intercostal artery perforator flap, anterior intercostal perforator flap) etc. Serratus anterior artery perforator flap, superior epigastric artery perforator flap, and lateral thoracic artery perforator flap can also be raised technically. To enhance surgical accuracy, it is necessary to evaluate the location and quality of perforator vessels preoperatively. Proper flap design is of more importance for pedicled flap when compared with it’s free flap counterpart. Although free flap approach remains the golden standard in breast reconstruction when considering autologous tissue transplantation, pedicled perforator flap has the apparent merits of minimized surgical trauma, less time-consuming and less stress for reconstructive surgeons.关键词：Pedicel perforator flap;Breast reconstruction;Perforator flap;Thoracodorsal artery perforator flap;Intercostal artery perforator ?ap;Serratus anterior artery perforator ?ap;Superior epigastric artery perforator flap;Lateral thoracic artery perforator ?ap2|6826|0更新时间：2025-12-31
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Joinpoint regression analysis for the trends of cervical cancer mortality between 1987-2014 in China
摘要：Background and purpose: Cervical cancer is one of the most common malignant tumors and poses a great threat to women’s fitness. Monitoring its present status and variations over the past 3 decades could provide scientific basis for prevention and control strategies of cervical cancer in China. Methods: This study collected the mortality rates of cervical cancer data in Chinese women from 1987 to 2014, described the features and trends of age-standardized rates and truncated rates, and estimated the variations via joinpoint regression models. Results: The mortality rates of cervical cancer for rural women were roughly higher than those for urban women. It showed downward trends for both urban and rural women, and the average rate of decrease for rural women (AAPC=3.94%, P<0.01) was higher than that for urban women (AAPC=1.79%, P<0.01). The gap between urban and rural areas was narrowing, with urban rates exceeding rural rates after 2010. The mortality rates of cervical cancer increased with time for urban women aged from 30 to 54, decreased with time for the elderly urban women and all the rural women. Conclusion: The overall mortality rates of cervical cancer took a desirable turn in China over the past 3 decades, while the status for the middle-aged urban women was getting worse as well as the elderly in both urban and rural areas during the past 10 years.关键词：Cervical cancer;Mortality;Joinpoint regression;Trends2|3081|0更新时间：2025-12-31 - 摘要：Background and purpose: Peroxiredoxin Ⅱ (PrxⅡ) has the activity of peroxidase. The relevant studies found it played an important role in gastric cancer. This study aimed to investigate the expression of PrxⅡ in human gastric cancer tissues and cells, analyze its relationship with clinicopathological characteristics, and explore the relationship between PrxⅡ and the prognosis and the development of gastric cancer. Methods: The expression of PrxⅡ mRNA and protein in gastric cancer tissues and the paired adjacent normal tissues from 45 patients was detected by real-time fluorescent quantitative polymerase chain reaction (RTFQ-PCR) and Western blot. The same methods were used to detect the expression of PrxⅡ mRNA and protein in GES-1, MGC-803, MKN-45 and MKN-28. Tissue microarray and immunohistochemistry were used to detect the expression of PrxⅡ protein in gastric cancer tissues and the paired adjacent normal tissues from 116 patients. The relationship between the results and clinicopathological characteristics was analyzed. The prognosis was analyzed. Results: According to results of RTFQ-PCR and Western blot, we found that PrxⅡ mRNA and protein in gastric cancer tissues were significantly higher than that in adjacent normal tissues (P<0.05). PrxⅡ mRNA and protein in gastric cancer cells were higher than that in normal gastric cells (P<0.01). Immunohistochemistry revealed that the expression of PrxⅡ protein in gastric cancer tissues (76.7%) was also significantly higher (P<0.01) than that in adjacent normal tissues (30.1%). The expression of PrxⅡ protein is significantly related to tumor size, histological differentiation, depth of invasion, TNM stage and lymph node metastasis (P<0.05), but had no significant relationship with the gender, age, tumor location and distant metastasis. Survival in patients with higher PrxⅡ expression significantly shorter than in those with lower expression (P<0.01). PrxⅡ is an independent prognostic factor of gastric cancer (P<0.05). Conclusion: PrxⅡ promotes the development of gastric cancer. It is one of the adverse prognostic factors of gastric cancer and may serve as a new therapeutic target for gastric cancer.关键词：Peroxiredoxin Ⅱ;Gastric cancer;Real-time fluorescent quantitative polymerase chain reaction;Tissue microarray2|1532|0更新时间：2025-12-31
- 摘要：Background and purpose: Multidrug resistance of tumor cells is the main factor for the failure of chemotherapy. It is found that the apigenin has the anti-tumor effect, but its role in multidrug resistant cells was rarely reported. This study aimed to investigate the effect of apigenin on multidrug resistant breast cancer cell line MCF-7/ ADR, and to explore the role of apigenin in reversing multidrug resistance. Methods: The MCF-7/ADR cells were cultured with different concentrations of apigenin, and the same cells were cultured with ADR in the control group. The cell proliferation was detected by MTT, the cell cycle distribution was detected by PI, and the cell apoptosis was detected by Annexin V/PI. The drug sensitivity in vitro was detected by the method of MTT, and the drug retention rate was detected by rhodamine 123 accumulation. The expression of P-gp protein was measured by Western blot, the RT-PCR method was used to detect the transcription of multidrug resistance gene MDR1. Results: The MCF-7/ADR cell proliferation was inhibited by the apigenin, the cell cycle progression was blocked by the apigenin, and the cell apoptosis was induced by the apigenin. There were significant differences between the apigenin group and the ADR group (P<0.05). The IC50 of ADR on MCF-7/ADR cell was (12.37±0.18) μg/mL with the apigenin effect, while the IC50 of ADR on MCF-7/ADR cell was (39.83±0.29) μg/mL without the apigenin effect (P<0.05). The reversal index was 3.22. The retention rate of rhodamine 123 in MCF-7/ADR cells in the apigenin group was higher than that in the ADR group. The MDR1 gene transcription level in MCF-7/ADR cells was higher than that in the MCF-7 cells, and the P-gp expression in MCF-7/ADR cells was higher than that in the MCF-7 cells. However, the level of MDR1 gene transcription and P-gp expression were down-regulated by the apigenin in the MCF-7/ADR cells. Conclusion: The apigenin had anti-MCF-7/ADR effect, and played the role of reversing multidrug resistance in the MCF-7/ADR cells. The mechanism may be related to down-regulation of the MDR1 gene transcription and the P-gp mediated drug efflux function.关键词：芹菜素;乳腺癌多药耐药;细胞凋亡;逆转2|2053|0更新时间：2025-12-31
- 摘要：Background and purpose: Paget’s disease (PD) of the breast is a rare disease. The survival of PD was reported to be related to the characteristics of the underlying carcinoma. This study aimed to investigate the characteristics and survival of PD patients with underlying invasive breast carcinoma (IBC). Methods: Fifty-four patients diagnosed with PD and an associated IBC in Fudan University Shanghai Cancer Center from 2002 to 2007 were recruited in this study as study group. Since most PD overexpress HER-2, 72 patients with HER-2-overexpressing breast cancer were randomly recruited as control group. This study compared survival between these two groups. Results: Twenty-five (46.3%) patients in study group had no clinical manifestation of PD and were diagnosed unexpectedly by a histologic examination. Thirty-five (64.8%) patients in study group had tumors larger than 2 cm, twenty-six(48.1%) patients in study group had chance of axillary lymph node involvement. Compared with control group, patients in study group tended to have more events (5-year relapse-free survival: 76.4% vs 48.5%, P<0.01). In the control group, most events occurred in the first 3 years after operation, while recurrence might happen all along in the 5 years after operation in study group. Patients in study group also had a poorer overall survival than in control group (61.0% vs 80.6%, P=0.01). Conclusion: Patients with Paget’s disease and underlying invasive breast cancer tend to have poorer survival than those with HER-2-overexpressing breast cancer.关键词：Paget’s disease;HER-2;Invasive breast cancer;Survival analysis2|3167|0更新时间：2025-12-31
- 摘要：Background and purpose: At present, the treatment of elderly patients with ovarian cancer, especially advanced ovarian cancer, tends to be conservative, and elderly patients often can not receive standard treatment. There are few treatment experiences and research data. This study aimed to investigate the treatment outcome, survival and prognostic factors of elderly patients with advanced epithelial ovarian cancer. Methods: This study retrospectively analyzed the clinical data for women older than 65 years diagnosed with stage Ⅲ and Ⅳ epithelial ovarian cancer between Apr. 2008 to Dec. 2012 in Chongqing Cancer Hospital. Results: Of the 181 women who met study criteria, 8.8% received no treatment, 12.7% underwent surgery alone, 15.5% received chemotherapy alone, 33.2% underwent non-standard treatment, 29.8% underwent standard treatment. Baseline comparison of different treatment methods showed that the proportion of patients with cardiovascular and cerebrovascular diseases was lower in the standard treatment group. After Correcting the effect of cardio-cerebrovascular diseases, the median survival time of standard treatment (48 months) and the median survival time of non-standard treatment (47 months) were significantly longer than that of the other treatment groups (P<0.001). The median survival time of chemotherapy alone (26 months) was significantly longer than that of the surgery alone and untreated group (P<0.001), while the median survival time of surgery alone was similar to untreated group (9 months vs 8 months, P=0.269). Multivariate analysis using Cox model showed that treatment, residual lesion size, cardio-cerebrovascular diseases significantly impacted on survival time. Conclusion: Standard treatment was still the key factor for the best survival of elderly women with advanced ovarian cancer. When this is not offered or possible, chemother-apy alone offers better survival than surgery alone. However, surgery alone does not improve prognosis.关键词：Old age;Ovarian neoplasms;Prognosis;Chemotherapy2|2775|0更新时间：2025-12-31
- 摘要：Long non-coding RNA (lncRNA) is a group of functional RNA molecules, which is more than 200 nucleotides in length, lacks ability of encoding protein and participates in all aspects of gene regulation. The current studies have indicated that some lncRNAs take part in regulating the process of breast cancer tumorigenesis and progression. This article reviewed the abnormal expression of lncRNA in breast cancer, its relationship to breast cancer growth, apoptosis, invasion and metastasis, and its function in early diagnosis, drug resistance and prognosis of breast cancer. This review was expected to offer an insight into a new target for the prediction, diagnosis and individual treatment of breast cancer.关键词：Long non-coding RNA;Breast cancer;Tumorigenesis;Progression;Molecular marker2|2147|0更新时间：2025-12-31
- 摘要：Several multi-gene assays have been developed to predict the risk of recurrence in patients with early-stage, estrogen receptor (ER) positive breast cancer. Among them, Oncotype DX 21-gene assay is widely applied among node-negative patients because of its unique prediction of therapeutic benefit. Although many retrospective studies have proved its prognostic and predictive value in node-positive population, evidence from large prospective clinical trials remains insufficient. When combined with clinicopathological variables, the assay has been shown to impact adjuvant treatment decision making in a cost-effective manner. This article reviewed the available clinical evidence for the prognostic and predictive value, unique advantages, the effect on treatment decision making, cost-effectiveness and contradictories of 21-gene assay in early-stage luminal breast cancer patients.关键词：Breast cancer;Oncotype DX;21-gene assay;Prognosis;Chemotherapy2|3594|0更新时间：2025-12-31
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