Abstract: With the data generated in recent years, the new issues encountered by practicing physicians in endocrine therapy for breast cancer have been warmly discussed. Meanwhile, the hot discussion brought us new ways of thinking. Based on the new evidence and clinical experience, this article rediscussed the application of ovarian function suppression (OFS) and the appropriate choice of endocrine drugs combining with OFS. We focused on the management of the adverse effects in patients using OFS plus aromatase inhibitor, the fertility problems and prolonged endocrine treatment in breast cancer patients.

Key words: Breast cancer, Endocrine therapy, Treatment