Abstract: Nucleotide-binding oligomerization domain (NOD)-like receptor, a member of pathogen recognition receptors existing in the cytoplasm, is of vital importance to innate immunity. NOD-like receptor is activated, it wil induce the release of plenty of inflammatory factors through a variety of signaling pathways. This review presents the constitution of NOD-like receptor, NODmediated signaling pathways and the relationship between NOD-like receptor and tumors.

Key words: Nucleotide-binding oligomerization domain-like receptor, Signaling pathway, Tumor