The correlation study between the glucose metabolism of 18F-FDG PET/CT incidental thyroid cancer and clinicopathologic characteristics

李雪娜; 尹雅芙; 杜补林

doi:10.19401/j.cnki.1007-3639.2016.06.008

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The correlation study between the glucose metabolism of 18F-FDG PET/CT incidental thyroid cancer and clinicopathologic characteristics

更新时间：2025-12-31

- The correlation study between the glucose metabolism of 18F-FDG PET/CT incidental thyroid cancer and clinicopathologic characteristics
- China Oncology Vol. 26, Issue 6, Pages: 527-532(2016)
- 作者机构：
  
  中国医科大学附属第一医院核医学科,辽宁,沈阳,110001
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2016.06.008
  CLC：
- Published Online：28 July 2016，
  
  Published：28 July 2016
- 稿件说明：
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李雪娜,尹雅芙,杜补林,等.

李雪娜, 尹雅芙, 杜补林. The correlation study between the glucose metabolism of 18F-FDG PET/CT incidental thyroid cancer and clinicopathologic characteristics[J]. China Oncology, 2016, 26(6): 527-532.
李雪娜,尹雅芙,杜补林,等. DOI： 10.19401/j.cnki.1007-3639.2016.06.008.

李雪娜, 尹雅芙, 杜补林. The correlation study between the glucose metabolism of 18F-FDG PET/CT incidental thyroid cancer and clinicopathologic characteristics[J]. China Oncology, 2016, 26(6): 527-532. DOI： 10.19401/j.cnki.1007-3639.2016.06.008.

摘要

背景与目的：

F-FDG PET/CT的广泛应用导致偶发甲状腺癌的比例明显增加，偶发甲状腺癌灶的糖代谢与甲状腺癌病理学的相关性尚不清楚。研究因非甲状腺疾病行

F-FDG PET/CT显像、偶发甲状腺癌的患者，分析甲状腺癌灶的糖代谢与肿瘤的分化程度、淋巴结转移的相关性。方法：回顾性分析

F-FDG PET/CT显像偶发甲状腺瘤患者195例，53例患者手术病理诊断为甲状腺癌。分别测量甲状腺癌灶的最大标准摄取值(SUV

max

)、病变大小、病变个数，同时测量患者正常甲状腺组织的SUV

max

。通过病理分析病理学分型、淋巴结转移，患者分为G

组(分化型甲状腺癌)、G

组(非分化型甲状腺癌)、G

组(甲状腺癌无淋巴结转移)和G

组(甲状腺癌有淋巴结转移)。分析G

组与G

组、G

组与G

组间甲状腺癌灶的糖代谢的差异。结果：53例患者中，PET显像发现甲状腺癌灶53个。病理学发现甲状腺癌灶62个，乳头状甲状腺癌37例，滤泡状甲状腺癌4例，髓样癌9例，低分化癌3例。正常甲状腺组织的SUVmax为1.51±0.30，G

组(41例)SUV

max

为4.25±1.70，G

组(12例)SUV

max

为6.34±2.45，G

组和G

组的SUV

max

均显著高于正常甲状腺组织(t=11.0，t=7.10，P0.01)，但G

组与G

组的SUV

max

差异无统计学意义(t=3.61，P0.05)。G

组(29例)的SUV

max

为4.77±2.15，G

组(24例)的SUV

max

为4.67±2.02，差异无统计学意义(t=0.33，P=0.56)。结论：

F-FDG PET/CT显像偶发癌分化型甲状腺癌、非分化型甲状腺癌均具有高糖代谢改变；不同分化程度、淋巴结转移能力的甲状腺癌灶的糖代谢水平差异无统计学意义。

Abstract

Background and purpose: The proportion of incidental thyroid cancer in PET imaging was s

ignificantly increased with the wide application of

F-FDG PET/CT. The correlation between the glucose metabolism of thyroid incidental thyroid cancer and pathological changes is unclear. The objective of this study is to analyze the relationship between the glucose metabolism by

F-FDG PET/CT and tumor differentiation or lymph node metastasis in patients with incidental thyroid cancer. Methods: A total of 195 patients with focal FDG-avid thyroid incidentaloma during cancer evaluation were enrolled. Fifty-three patients were diagnosed as having thyroid cancer by the pathology. The SUV

max

of thyroid cancer foci

lesion size

lesion number

and SUV

max

of normal thyroid tissue were quantified. The tumor pathological grades and lymph node metastasis were analyzed by the pathology. The patients were broken down into 4 groups (G

and G

) according to the tumor pathological grades and lymph node metastasis (differentiated thyroid cancer

non-differentiated thyroid cancer

without lymph node metastasis and with lymph node metastasis). The differences of glucose metabolism between G

and G

groups

and G

groups were analyzed. Results: Fifty-three foci were found by PET imaging. Sixty-two foci were found by the pathology (37 papillary thyroid carcinoma

4 follicular thyroid carcinoma

9 medullary thyroid carcinoma

3 poorly differentiated thyroid cancer). The SUV

max

in the normal thyroid tissue

and G

were 1.51±0.30

4.25±1.70 and 6.34±2.45

respectively. The SUV

max

in the G

and G

were significantly higher than in the normal thyroid tissue (t=11.0，t=7.10，P0.01). The SUV

max

of G

was 4.77±2.15

and the SUV

max

of G

group was 4.67±2.02. The differences between G

and G

groups

and G

groups were not statistically signif

icant (t=3.61

P0.05; t=0.33

P=0.56). Conclusion: The differentiated incidental thyroid carcinoma and non-differentiated incidental thyroid carcinoma had high glucose metabolism

and there was no significant difference in the levels of glucose metabolism in different differentiation degree and metastasis ability cancer.

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