Lymphoma and cAMP signaling pathway

钟　瑶; 朱　琦

doi:10.19401/j.cnki.1007-3639.2016.06.013

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Lymphoma and cAMP signaling pathway

更新时间：2025-12-31

- Lymphoma and cAMP signaling pathway
- China Oncology Vol. 26, Issue 6, Pages: 556-560(2016)
- 作者机构：
  
  上海交通大学附属第九人民医院血液内科,上海,200011
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2016.06.013
  CLC：
- Published Online：28 July 2016，
  
  Published：28 July 2016
- 稿件说明：
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钟　瑶,朱　琦. 淋巴瘤和cAMP信号通路[J]. 中国癌症杂志, 2016, 26(6): 556-560.

钟　瑶, 朱　琦. Lymphoma and cAMP signaling pathway[J]. China Oncology, 2016, 26(6): 556-560.
钟　瑶,朱　琦. 淋巴瘤和cAMP信号通路[J]. 中国癌症杂志, 2016, 26(6): 556-560. DOI： 10.19401/j.cnki.1007-3639.2016.06.013.

钟　瑶, 朱　琦. Lymphoma and cAMP signaling pathway[J]. China Oncology, 2016, 26(6): 556-560. DOI： 10.19401/j.cnki.1007-3639.2016.06.013.

摘要

淋巴瘤细胞克隆性增殖和疾病进展涉及细胞内多个信号通路。环腺苷酸(cyclic adenosine monophosphate，cAMP)信号通路作为一种重要的细胞内信息传递系统参与细胞增殖、分泌、代谢和凋亡等多种生理过程的调控。靶向调变cAMP信号通路可以诱导多种恶性淋巴瘤细胞增殖阻滞和凋亡，其机制涉及线粒体介导细胞凋亡、cAMP调控蛋白激酶和多种细胞内调控因子。对cAMP介导淋巴瘤细胞凋亡深入研究分析，将为临床治疗淋巴瘤提供可能途径和潜在靶点。

Abstract

Several signaling pathways are involved in clonal proliferation of lymphoma cells and disease progression. It has been shown that cyclic adenosine monophosphate (cAMP) signaling pathway

as an important intracellular messenger delivery system

is related to modulation of multiple physiological processes including cell proliferation

secretion

metabolism and apoptosis. Manipulating the cAMP signaling pathway can induce cell cycle arrest and apoptosis of various malignant lymphoid cells

which involves mitochondria-dependent apoptosis and cAMP-modulated protein kinases as well as changes of intracellular mediators. In-depth research and analysis of cAMP-induced apoptosis in lymphoma cells would provide potential targets and possible therapeutic means for the treatment of lymphoma.

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