Role of the dynamic contrast-enhanced MRI in assessing the response to neoadjuvant chemotherapy of breast cancer

李瑞敏; 顾雅佳; 彭卫军

doi:10.19401/j.cnki.1007-3639.2016.07.010

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Role of the dynamic contrast-enhanced MRI in assessing the response to neoadjuvant chemotherapy of breast cancer

更新时间：2025-12-31

- Role of the dynamic contrast-enhanced MRI in assessing the response to neoadjuvant chemotherapy of breast cancer
- China Oncology Vol. 26, Issue 7, Pages: 623-628(2016)
- 作者机构：
  
  复旦大学附属肿瘤医院放射诊断科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2016.07.010
  CLC：
- Published Online：22 August 2016，
  
  Published：22 August 2016
- 稿件说明：
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李瑞敏,顾雅佳,彭卫军,等. 定量动态增强磁共振评估乳腺癌新辅助化疗疗效的应用研究[J]. 中国癌症杂志, 2016, 26(7): 623-628.

李瑞敏, 顾雅佳, 彭卫军. Role of the dynamic contrast-enhanced MRI in assessing the response to neoadjuvant chemotherapy of breast cancer[J]. China Oncology, 2016, 26(7): 623-628.
李瑞敏,顾雅佳,彭卫军,等. 定量动态增强磁共振评估乳腺癌新辅助化疗疗效的应用研究[J]. 中国癌症杂志, 2016, 26(7): 623-628. DOI： 10.19401/j.cnki.1007-3639.2016.07.010.

李瑞敏, 顾雅佳, 彭卫军. Role of the dynamic contrast-enhanced MRI in assessing the response to neoadjuvant chemotherapy of breast cancer[J]. China Oncology, 2016, 26(7): 623-628. DOI： 10.19401/j.cnki.1007-3639.2016.07.010.

摘要

背景与目的：乳腺癌的新辅助化疗(neoadjuvant chemotherapy

NAC)已成为成熟的治疗方法，但疗效评估尚未有统一有效的方法。该研究即探讨定量动态增强磁共振在乳腺癌NAC疗效评估中的价值。方法：24例术前行NAC的乳腺癌确诊患者(24例均为浸润性导管癌)，分别于NAC前、第2个疗程后、化疗结束但术前3个时间点行定量动态增强磁共振检查，分析NAC前后肿瘤最长径及动态增强磁共振定量参数：容量转移常数(K

trans

)、速率常数 (K

)、血管外细胞外间隙容积比(V

)的变化。结果：24例患者均为单侧单发乳腺癌病灶，以RECIST标准分为有效组(17个)和无效组(7个)，有效组与无效组K

trans

、K

在NAC前与第2个疗程、化疗前与化疗结束差异均有统计学意义(P0.05)，V

在有效组与无效组治疗前后差异均无统计学意义(P0.05)。结论：定量动态增强磁共振可用来评估NAC疗效，并且K

trans

、K

可做到定量，使评估结果更为客观真实，但V

对判断治疗效果未见明显优势。

Abstract

Background and purpose: Neoadjuvant chemotherapy to breast cancer has become a mature treatment method. The purpose of this study was to evaluate the dynamic contrast-enhanced MRI in assessing the response to neoadjuvant chemotherapy (NAC). Methods: Twenty-four female patients with breast carcinoma (24 were all invasive ductal carcinoma) underwent dynamic contrast-enhanced MRI (DCE-MRI) before

after the second and final cycle of NAC. For each patient and each MRI examination

the maximum diameter of tumor

volume transfer constant (K

trans

)

exchange rate constant (K

)

and extravascular extracellular volume fractio

n (V

) were compared. According to the method of response evaluation criteria in solid tumor (RECIST)

the results of neoadjuvant chemotherapy were divided into responder and non-responder. Results: All 24 patients were unilateral and single breast cancer; there were 17 cases of responders and 7 cases of non-responders according to RECIST criteria. For 17 cases of responders

both the average values of K

trans

and K

were significantly descended after neoadjuvant chemotherapy (all P0.05). Conclusion: The quantitative parameters of K

trans

and K

can evaluate objectively and veridically the response to neoadjuvant chemotherapy for breast cancer in dynamic contrast-enhanced MRI.

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