Waldeyer’s ring is a circular band of lymphoid tissue which is mainly composed of nasopharynx

oropharynx

tonsils

tongue base and hypopharynx. It is the most common site of non-Hodgkin’s lymphoma (NHL) in the head and neck

and the most common histologic subtype is diffuse large B-cell lymphoma (DLBCL). Because of the special anatomical structure

primary Waldeyer’s ring NHL has some unique clinical features. The diagnosis and treatment can partially refer to other nodal NHL. According to the literature reported in the past years

the international prognostic index (IPI)

performance status (PS)

age

stage

pathological type

treatment options may impact on the prognosis of the patients. Patients with limited stage could be treated with local radiotherapy. Systematic chemotherapy is widely used in patients with extensive stage. At present

for the patients with localized Waldeye's ring DLBCL

R-CHOP is the standard treatment

but there is no consensus about whether they should receive radiotherapy after immunochemotherapy. Due to the development of systematic treatment

whether subsequent radiotherapy can be omitted for patients with localized disease

especially for patients who have achieved complete response after immunochemotherapy

will become an important research topic.