Expressions and clinical significances of p57<sup>KIP2</sup>, cyclin D1 and cyclin E in primary carcinoma of the gallbladder

LUO Zuqiang; ZHUANG Zhiquan; TU Xiaomeng

doi:10.19401/j.cnki.1007-3639.2018.11.001

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Expressions and clinical significances of p57^KIP2, cyclin D1 and cyclin E in primary carcinoma of the gallbladder

更新时间：2026-01-27

- Expressions and clinical significances of p57^KIP2, cyclin D1 and cyclin E in primary carcinoma of the gallbladder
- China Oncology Issue 11, Pages: 801-806(2018)
- 作者机构：
  
  1. 温州医科大学附属第一医院病理科,浙江,温州,325000
  2. 温州医科大学第一临床医学院医学影像学系,浙江,温州,325000
  3. 温州医科大学附属眼视光医院中心实验室,浙江,温州,325000
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2018.11.001
  CLC：
- Published Online：14 December 2018，
  
  Published：14 December 2018
- 稿件说明：
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罗祖强,庄志泉,涂晓萌. 胆囊癌组织中p57

LUO Zuqiang, ZHUANG Zhiquan, TU Xiaomeng. Expressions and clinical significances of p57^KIP2, cyclin D1 and cyclin E in primary carcinoma of the gallbladder[J]. China Oncology, 2018, (11): 801-806.
罗祖强,庄志泉,涂晓萌. 胆囊癌组织中p57 DOI： 10.19401/j.cnki.1007-3639.2018.11.001.

LUO Zuqiang, ZHUANG Zhiquan, TU Xiaomeng. Expressions and clinical significances of p57^KIP2, cyclin D1 and cyclin E in primary carcinoma of the gallbladder[J]. China Oncology, 2018, (11): 801-806. DOI： 10.19401/j.cnki.1007-3639.2018.11.001.

摘要

背景与目的：原发性胆囊癌（primary carcinoma of the gallbladder，PCG）是死亡率极高的恶性肿瘤，其恶变的机制目前尚未明确。前期研究发现，p57

KIP2

在人类多种恶性肿瘤中异常表达。本研究拟进一步探讨p57

KIP2

在PCG组织中的表达及临床意义。方法：运用实时荧光定量聚合酶链反应（real-time fluorescence quantitative polymerase chain reaction，RTFQ-PCR）、免疫组织化学EliVision法分别检测60例PCG、20例胆囊腺瘤（adenoma of the gallbladder，AG）和20例慢性胆囊炎（chronic cholecystitis，CC）组织中p57

KIP2

、cyclin D1、cyclin E mRNA表达及蛋白水平。结果：p57

KIP2

mRNA及蛋白在PCG、AG和CC中的表达逐渐升高，两两比较差异有统计学意义（P0.05）。Cyclin D1、cyclin E mRNA及蛋白在PCG、AG和CC中的表达逐渐降低，PCG与AG比较、PCG与CC比较，差异有统计学意义（P0.05）。在PCG组织中，p57

KIP2

蛋白的表达与临床分期、组织学分级及淋巴结转移有关（P0.05）。Cyclin D1蛋白的表达与临床分期有关(P0.05)。p57

KIP2

与cyclin D1的表达呈负相关（P0.05），p57

KIP2

与cyclin E的表达呈负相关（P0.05），cyclin D1与cyclin E的表达呈正相关（P0.05）。结论：p57

KIP2

表达的降低与cyclin D1、cyclin E表达的增加可能是PCG的发生机制之一；检测p57

KIP2

、cyclin D1及cyclin E对PCG的预后判断有重要意义。

Abstract

Background and purpose: Primary carcinoma of the gallbladder (PCG) is a malignant tumor with extremely high mortality

and the mechanism of its malignant transformation is not yet clear. Previous studies found abnormal expression of p57

KIP2

in a variety of human malignant

tumors. This study aimed to analyze the expressions of p57

KIP2

cyclin D1 and cyclin E in PCG and their clinical significances. Methods: The mRNA expression and protein levels of p57

KIP2

cyclin D1 and cyclin E in 60 cases of PCG

20 cases of adenoma of the gallbladder (AG) and 20 cases of chronic cholecystitis (CC) were detected by real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR) and immunohistochemistry

respectively. Results: The mRNA expression and protein levels of p57

KIP2

in PCG

AG and CC increased gradually

and there were significant differences among the three groups (P0.05). The mRNA expression and protein levels of cyclin D1 and cyclin E in PCG

AG and CC decreased gradually. The difference between PCG and AG

or between PCG and CC was statistically significant. In PCG tissues

the protein expression of p57

KIP2

was associated with clinical stage

histological grade and node metastasis (P0.05). The protein level of cyclin D1 was associated with clinical stage (P0.05). There was a negative correlation between the expressions of p57

KIP2

and cyclin D1

or p57

KIP2

and cyclin E. However

the correlation between cyclin D1 and cyclin E expressions was positive (P0.05). Conclusion: Reduced level of p57

KIP2

and overexpression of cyclin E may be one of the mechanisms underlying carcinogenesis of PCG. p57

KIP2

cyclin D1 and cyclin E were independent prognostic factors for PCG.

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Expressions and clinical significances of p57KIP2, cyclin D1 and cyclin E in primary carcinoma of the gallbladder

DOI：10.19401/j.cnki.1007-3639.2018.11.001

摘要

Abstract

关键词

Keywords

references

Expressions and clinical significances of p57^KIP2, cyclin D1 and cyclin E in primary carcinoma of the gallbladder