The influence of F2RL3 on the proliferation, invasion, metastasis and glycolysis of renal cancer A498 cells

CAO Dalong; ZHU Wenkai; HUANG Yongqiang

doi:10.19401/j.cnki.1007-3639.2018.12.003

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The influence of F2RL3 on the proliferation, invasion, metastasis and glycolysis of renal cancer A498 cells

更新时间：2026-01-27

- The influence of F2RL3 on the proliferation, invasion, metastasis and glycolysis of renal cancer A498 cells
- China Oncology Vol. 28, Issue 12, Pages: 895-899(2018)
- 作者机构：
  
  复旦大学附属肿瘤医院泌尿外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2018.12.003
  CLC：
- Published Online：11 January 2019，
  
  Published：11 January 2019
- 稿件说明：
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曹达龙,朱文恺,黄永墙,等. F2RL3影响肾癌A498细胞增殖、侵袭、转移及糖酵解效应[J]. 中国癌症杂志, 2018, 28(12): 895-899.

CAO Dalong, ZHU Wenkai, HUANG Yongqiang. The influence of F2RL3 on the proliferation, invasion, metastasis and glycolysis of renal cancer A498 cells[J]. China Oncology, 2018, 28(12): 895-899.
曹达龙,朱文恺,黄永墙,等. F2RL3影响肾癌A498细胞增殖、侵袭、转移及糖酵解效应[J]. 中国癌症杂志, 2018, 28(12): 895-899. DOI： 10.19401/j.cnki.1007-3639.2018.12.003.

CAO Dalong, ZHU Wenkai, HUANG Yongqiang. The influence of F2RL3 on the proliferation, invasion, metastasis and glycolysis of renal cancer A498 cells[J]. China Oncology, 2018, 28(12): 895-899. DOI： 10.19401/j.cnki.1007-3639.2018.12.003.

摘要

背景与目的：F2R样凝血酶/胰蛋白酶受体3（F2R like thrombin or trypsin receptor 3，F2RL3）高表达与肾癌的不良预后密切相关，但其在肾癌发生、发展中的功能未见报道。本研究旨在探讨F2RL3与肾癌A498细胞恶性增殖、侵袭、转移和糖代谢的关系。方法：通过敲减肾癌A498细胞中F2RL3基因表达，检测细胞恶性增殖、侵袭、转移和吸收葡萄糖、产生乳酸能力的变化以及糖酵解通路中关键基因的表达。结果：F2RL3低表达可以抑制A498细胞的增殖、侵袭及转移能力，以及抑制葡萄糖的吸收和乳酸的生成，结果差异有统计学意义（P0.05）。结论：肾癌A498细胞中F2RL3可以正向调控细胞的增殖、侵袭、转移以及糖酵解效应。这些结果为研究肾癌细胞侵袭、转移与糖代谢之间的关系提供了重要的理论依据。

Abstract

Background and purpose: High expression of F2R like thrombin or trypsin receptor 3 (F2RL3) is associated with poor prognosis of renal cancer. However

the function of F2RL3 involved in development of renal cancer has not been reported. The aim of this paper was to investigate the correlation of F2RL3 with proliferation

invasion

metastasis and glycolysis in renal cancer A498 cells. Methods: By knockdown of the expression of F2RL3 gene in renal cancer A498 cells

the effects of F2RL3 on the proliferation

invasion

metastasis

glucose uptake

lactate production and the expression of key glycolytic genes were detected. Results: Decreased F2RL3 inhibited the proliferation

invasion and metastasis of renal cancer A498 cells

and suppressed the glycolytic effect of renal cancer A498 cells by inhibiting glucose uptake and lactate production (P0.005). Conclusion: F2RL3 positively regulated the proliferation

invasion

metastasis and the transformation of glucose metabolism in renal cancer A498 cells. These results provide important theoretical basis for studying the association of the invasion and metastasis of renal cancer with glucose metabolism.

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