Background and purpose: Microcystic meningioma is a rare subtype of meningiomas

which is rare in domestic and foreign reports

and is mostly reported in cases. This study aimed to explore the clinicopathological features and identification of microcystic meningioma. Methods: We retrospectively analyzed two cases of microcystic meningioma including their clinical manifestations

histological features and immunohistochemical phenotypes

and reviewed the relevant literature. Results: Two cases were middle-aged patients

one male and one female. The male patient was diagnosed as having traumatic brain hemorrhage whereas the female patient was treated for headache. The lesions were located in the left frontal and right frontal areas

the maximum diameters were 5.75 and 5.47 cm respectively. Imaging changes showed “brain tumor”. Microscopically

tumor cells were loosely arranged to form microcapsules of different sizes with the cavity containing powdered slurry

and the tumor cells had vacuolar cytoplasm and slender cytoplasmic processes without typical swirling structures and psammoma body. Immunohistochemistry showed vimentin

epithelial membrane antigen (EMA) and progesterone receptor (PR) were positive

S-100

glial fibrillary acidic protein (GFAP)

CD34 and creatine kinase (CK) were all negative

and positive rate of Ki-67 was 3%-5%. Both patients underwent surgical treatment and were followed up for 5-6 months. Before submission of this article in January 2018

both patients were generally in good condition

and no tumor recurrence was observed. Conclusion: Microcystic meningioma is a special subtype of meningiomas

and histopathology and immunohistochemistry can confirm the diagnosis. The current treatment is mainly surgery

and the prognosis is good.