Comparison of the prognostic classifications between the 7<sup>th</sup>and 8<sup>th</sup>editions of AJCC cancer staging manual for breast cancer

张凤春

doi:10.19401/j.cnki.1007-3639.2019.01.007

您当前的位置：

首页 >

文章列表页 >

Comparison of the prognostic classifications between the 7^thand 8^theditions of AJCC cancer staging manual for breast cancer

更新时间：2026-01-27

- Comparison of the prognostic classifications between the 7^thand 8^theditions of AJCC cancer staging manual for breast cancer
- China Oncology Vol. 29, Issue 1, Pages: 45-51(2019)
- 作者机构：
  
  1. 上海交通大学医学院附属苏州九龙医院肿瘤科,江苏,苏州,215021
  2. 上海交通大学医学院附属瑞金医院肿瘤科,上海,200025
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2019.01.007
  CLC： R737.9
- Published Online：01 February 2019，
  
  Published：01 February 2019
- 稿件说明：
移动端阅览
张凤春,左丽,马越,等. AJCC第7版与第8版分期对乳腺癌患者预后预测的比较分析[J]. 中国癌症杂志, 2019, 29(1): 45-51.

张凤春. Comparison of the prognostic classifications between the 7^thand 8^theditions of AJCC cancer staging manual for breast cancer[J]. China Oncology, 2019, 29(1): 45-51.
张凤春,左丽,马越,等. AJCC第7版与第8版分期对乳腺癌患者预后预测的比较分析[J]. 中国癌症杂志, 2019, 29(1): 45-51. DOI： 10.19401/j.cnki.1007-3639.2019.01.007.

张凤春. Comparison of the prognostic classifications between the 7^thand 8^theditions of AJCC cancer staging manual for breast cancer[J]. China Oncology, 2019, 29(1): 45-51. DOI： 10.19401/j.cnki.1007-3639.2019.01.007.

摘要

背景与目的：美国癌症联合委员会（American Joint Committee on Cancer，AJCC）第8版乳腺癌分期在传统解剖因素基础上，结合生物标志物，建立了一种全新的乳腺癌预后分期系统。该研究旨在分析AJCC第8版乳腺癌分期的临床应用价值。方法：分析222例乳腺癌根治术后出现复发转移的患者，按照AJCC第7版解剖分期：肿瘤（tumor，T）分期、淋巴结（node，N）分期、转移（metastasis，M）分期，和第8版预后分期标准进行初诊状态再分期，比较不同标准分期的差异及与预后的关系，生存分析采用Kaplan-Meier方法，log-rank法检验无病生存期（disease-free survival，DFS）的差异。结果：按照AJCC第7版分期标准，ⅠA、ⅠB、ⅡA、ⅡB、ⅢA、ⅢB和ⅢC期的患者分别为34例（15.3%）、0例（0.0%）、73例（32.9%）、26例（11.7%）、45例（20.3%）、4例（1.8%）和40例（18.0%）；按照AJCC第8版预后分期标准，ⅠA、ⅠB、ⅡA、ⅡB、ⅢA、ⅢB和ⅢC期的患者分别为47例（21.2%）、35例（15.8%）、55例（24.8%）、17例（7.7%）、25例（11.3%）、30例（13.5%）和13例（5.9%），差异有统计学意义（P=0.000）。分期变化主要有：第7版Ⅰ期细分为第8版ⅠA和ⅠB期；第7版ⅡA期细分为第8版ⅠA、ⅠB和ⅡA期；第7版ⅡB期细分为第8版ⅠA、ⅠB、ⅡA、ⅡB和ⅢA期；第7版ⅢA期细分为第8版ⅠB、ⅡA、ⅡB、ⅢA、ⅢB和ⅢC期；第7版ⅢB和ⅢC期细分为第8版ⅢA、ⅢB和Ⅲc期。AJCC第7版TNM分期和第8版预后分期与患者DFS比较差异均有统计学意义（P=0.002和0.001），第8版预后分期ⅢB和ⅢC期亚组的DFS更为准确。结论： AJCC第8版预后分期能够准确预测乳腺癌患者的预后。

Abstract

Background and purpose: The American Joint Committee on Cancer (AJCC) 8th edition cancer staging manual introduced a new prog

nostic staging system for breast cancer incorporating biological markers in addition to traditional anatomical factors. The purpose of this study was to determine the clinical value of the 8th edition AJCC classification for breast cancer. Methods: The data from 222 recurrent or metastatic cases of breast cancer after operation were analyzed. Cancer staging was determined using the 7

edition anatomical staging criteria including tumor (T)

node (N) and metastasis (M)

and was further evaluated using 8

edition prognostic classification. We compared the two staging systems and their relations to prognosis. Kaplan-Meier and log-rank tests were used for univariate comparison of disease-free survival (DFS). Results: The percentages of ⅠA

ⅠB

ⅡA

ⅡB

ⅢA

ⅢB and ⅢC were 34 (15.3%)

0 (0.0%)

73 (32.9%)

26 (11.7%)

45 (20.3%)

4 (1.8%) and 40 (18.0%) according to AJCC 7th edition anatomical TNM staging system

respectively. The percentages of ⅠA

ⅠB

ⅡA

ⅡB

ⅢA

ⅢB and ⅢC were 47 (21.2%)

35 (15.8%)

55 (24.8%)

17 (7.7%)

25 (11.3%)

30 (13.5%) and 13 (5.9%) according to AJCC 8th edition prognostic staging system

respectively. The difference between the two staging groups was significant (P=0.000). Changes occurred mainly in the following categories: the 7

edition ⅠA was divided into the 8

edition ⅠA and ⅠB categories; ⅡA was divided into ⅠA

ⅠB and ⅡA; ⅡB was divided into ⅠA

ⅠB

ⅡA

ⅡB and ⅢA; ⅢA was divided into ⅠB

ⅡA

ⅡB

ⅢA

ⅢB and ⅢC; and both the 7

edition ⅢB and ⅢC were divided into the 8

edition ⅢA

ⅢB and ⅢC categories. There was statistically significant difference in DFS between stage groups according to both AJCC 7

edition TNM and 8

edition prognostic staging systems (P=0.002 and 0.001)

and the DFS in ⅢB and ⅢC groups according to AJCC 8th edition prognostic staging system was more accurate compared with AJCC 7

edition. Conclusion: The 8

edition AJCC prognostic classificatio

n could exactly predict the prognosis of breast cancer.

关键词

Keywords

references

Views

4657

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinicopathologic features of SMARCA4-deficient pulmonary malignant tumor with an emphasis on the prognosis

Treatment strategies and prognostic analysis of 87 patients with salivary duct carcinoma: a retrospective cohort study

Impact of radiation-induced lymphopenia on prognosis in patients with limited-stage small cell lung cancer: a cohort study

MITF expression in acral melanoma tissues and its association with clinical, pathological characteristics and prognosis

Mechanisms of PTEN-regulated PDK1 in modulating malignant phenotypes of clear cell renal cell carcinoma

Related Author

CHANG Kesheng

SHAO Jin

ZHANG Qi

LIU Yifei

Ximei ZHANG

Yixuan ZHOU

Yan ZHAO

Xuan ZHOU

Related Institution

Department of Pathology, Wuxi Second People’s Hospital

Department of Pathology, Affiliated Hospital of Nantong University

Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Malignant Tumors

Tianjin Clinical Research Center for Malignant Tumors

Stomatological Clinical College of Tianjin Medical University

AI问答

⁰

Comparison of the prognostic classifications between the 7thand 8theditions of AJCC cancer staging manual for breast cancer

DOI：10.19401/j.cnki.1007-3639.2019.01.007

摘要

Abstract

关键词

Keywords

references

Comparison of the prognostic classifications between the 7^thand 8^theditions of AJCC cancer staging manual for breast cancer