Correlation between genetic variants in<em>CD</em>44 gene and cervical cancer and non-small cell lung cancer

赵雨笛; 严志凌; 李盈甫; 戴书颖; 周紫云; 张新文; 刘舒媛; 姚宇峰

doi:10.19401/j.cnki.1007-3639.2019.04.006

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Correlation between genetic variants inCD44 gene and cervical cancer and non-small cell lung cancer

更新时间：2026-01-27

- Correlation between genetic variants inCD44 gene and cervical cancer and non-small cell lung cancer
- China Oncology Vol. 29, Issue 4, Pages: 277-283(2019)
- 作者机构：
  
  1. 中国医学科学院/ 北京协和医学院医学生物学研究所，云南省重大传染病疫苗研发重点实验室，
  2. 昆明医科大学第一附属医院干部医疗科,云南,昆明,650032
  3. ,云南,昆明,650118
  4. 昆明医科大学第三附属医院妇科,云南,昆明,650118
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2019.04.006
  CLC： R734.2
- Published Online：17 May 2019，
  
  Published：17 May 2019
- 稿件说明：
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赵雨笛，谭芳，严志凌，李盈甫，戴书颖，周紫云，张新文，刘舒媛，史荔，姚宇峰.

赵雨笛, 严志凌, 李盈甫, et al. Correlation between genetic variants inCD44 gene and cervical cancer and non-small cell lung cancer[J]. China Oncology, 2019, 29(4): 277-283.
赵雨笛，谭芳，严志凌，李盈甫，戴书颖，周紫云，张新文，刘舒媛，史荔，姚宇峰. DOI： 10.19401/j.cnki.1007-3639.2019.04.006.

赵雨笛, 严志凌, 李盈甫, et al. Correlation between genetic variants inCD44 gene and cervical cancer and non-small cell lung cancer[J]. China Oncology, 2019, 29(4): 277-283. DOI： 10.19401/j.cnki.1007-3639.2019.04.006.

摘要

背景与目的：CD44分子是众多肿瘤细胞的标志分子，其表达水平与肿瘤细胞的恶性程度有关。该研究探讨CD44基因中的单核苷酸多态性（single nucleotide polymorphism，SNP）位点与云南汉族人群宫颈癌和非小细胞肺癌（nonsmall cell lung cancer，NSCLC）易感性的相关性。方法：选取了CD44基因中的两个SNP位点rs13347和rs8193，采用TagMan基因分型的方法，分析这两个多态性位点在497例宫颈癌患者和500例健康对照个体以及483例NSCLC患者和471例健康对照个体中的分布特征，并分析CD44基因中的多态性位点与云南汉族人群宫颈癌和NSCLC的相关性。结果：rs13347和rs8193位点等位基因和基因型在宫颈癌组和对照组中的分布频率的差异无统计学意义（P0.05）。而在NSCLC组和对照组的比较中：rs13347和rs8193位点等位基因在NSCLC组和对照组中的分布频率的差异有统计学意义（P=0.020和P=0.004）；这两个位点基因型在NSCLC组和对照组中分布频率的差异有统计学意义（P=0.027和P=0.020）；其中rs13347位点等位基因C在NSCLC组中的分布频率显著高于对照组，可能是NSCLC发生的风险因素（OR=1.250，95% CI：1.035～1.509），rs8193位点等位基因C在对照组中的分布频率显著高于NSCLC组，可能是NSCLC发生的保护性因素（OR=0.768，95%CI：0.641～0.921）。单倍型分析结果显示，rs13347C-rs8193T和rs13347T-rs8193C在NSCLC组和对照组中的分布频率差异有统计学意义（P=0.003和0.022）；该结果说明单倍型rs13347C-rs8193T可能是云南汉族人群NSCLC发生的风险性因素（OR=1.316，95%CI：1.096～1.579）。结论：CD44基因中的两个SNP位点rs13347和rs8193可能与云南汉族人群宫颈癌发病风险无关，而可能与云南汉族人群NSCLC具有相关性。

Abstract

Background and purpose: CD44 is a biomarker for many human malignant tumors

and the expression level of CD44 might be associated with malignancy of cancers. Thus

in the current study

we investigated the association between single nucleotide polymorphisms (SNP) in CD44 gene and cervical cancer and non-small cell lung cancer (NSCLC) in a Yunnan Han population. Methods: For cervical cancer

497 patients and 500 healthy individuals were recruited. For NSCLC

483 patients and 471 healthy individuals were recruited. Two SNP in CD44 gene (rs13347

rs8193) were genotyped using TaqMan assay. And the association between the two SNP and the tumors was analyzed. Results: For cervical cancer

the allelic and genotypic frequencies of rs13347 and rs8193 were not significantly different between patients with cervical cancer and control groups (P0.05). For NSCLC

the allelic frequencies of rs13347 and rs8193 were significantly different between NSCLC and control groups (P=0.020 and P=0.004). The C allele of rs13347 occurred more frequently in NSCLC group than in control group and might be the risk factor for NSCLC (OR=1.250

95% CI: 1.035-1.509). The C allele of rs8193 occurred significantly more frequently in control group compared with NSCLC group

and might be a protective factor for NSCLC (OR=0.768

95% CI: 0.641-0.921). The genotypic frequencies of rs13347 and rs8193 were significantly different between NSCLC and control groups (P=0.027 and P=0.020). Additionally

the results of haplotype analysis showed that rs13347C-rs8193T haplotype might be associated with higher risk of NSCLC (P=0.003

OR=1.316

95% CI: 1.096-1.579). Conclusion: The two SNP in the CD44 gene (rs13347

rs8193) might be only associated with the risk of NSCLC

but not cervical cancer in the Yunnan Han population.

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Correlation between genetic variants inCD44 gene and cervical cancer and non-small cell lung cancer

DOI：10.19401/j.cnki.1007-3639.2019.04.006

摘要

Abstract

关键词

Keywords

references