Research progress of tumor microenvironment of esophageal squamous cell carcinoma

李一达; 邹丽晴; 朱正飞

doi:10.19401/j.cnki.1007-3639.2019.04.011

您当前的位置：

首页 >

文章列表页 >

Research progress of tumor microenvironment of esophageal squamous cell carcinoma

更新时间：2026-01-27

- Research progress of tumor microenvironment of esophageal squamous cell carcinoma
- China Oncology Vol. 29, Issue 4, Pages: 307-312(2019)
- 作者机构：
  
  复旦大学附属肿瘤医院放疗科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2019.04.011
  CLC： R735.1
- Published Online：17 May 2019，
  
  Published：17 May 2019
- 稿件说明：
移动端阅览
李一达，邹丽晴,朱正飞 . 食管鳞癌肿瘤微环境相关研究进展[J]. 中国癌症杂志, 2019, 29(4): 307-312.

李一达, 邹丽晴, 朱正飞. Research progress of tumor microenvironment of esophageal squamous cell carcinoma[J]. China Oncology, 2019, 29(4): 307-312.
李一达，邹丽晴,朱正飞 . 食管鳞癌肿瘤微环境相关研究进展[J]. 中国癌症杂志, 2019, 29(4): 307-312. DOI： 10.19401/j.cnki.1007-3639.2019.04.011.

李一达, 邹丽晴, 朱正飞. Research progress of tumor microenvironment of esophageal squamous cell carcinoma[J]. China Oncology, 2019, 29(4): 307-312. DOI： 10.19401/j.cnki.1007-3639.2019.04.011.

摘要

食管鳞癌是我国食管癌的主要类型，危害严重。近年来，许多研究发现，其发生、发展与所在的肿瘤微环境密切相关。食管鳞癌细胞所在的肿瘤微环境可通过调控免疫微环境、释放细胞因子、改变血管生成等多种途径促进食管鳞癌细胞生长、侵袭和转移，并造成免疫逃逸。本综述从白介素-6（interleukin-6，IL-6）、程序性死亡［蛋白］-1（programmed death-1，PD-1）/程序性死亡［蛋白］配体-1（programmed death ligand-1，PD-L1）、转化生长因子-β（transforming growth factor-β，TGF-β）、乏氧诱导因子-1（hypoxia inducible factor-1，HIF-1）及血管内皮细胞生长因子（vascular endothelial growth factor，VEGF）等影响食管鳞癌肿瘤微环境的重要通路方面，阐述肿瘤微环境与食管鳞癌预后的关系及相关机制，并介绍相关靶向治疗的研究进展，旨在为食管鳞癌的防治研究提供参考。

Abstract

Esophageal squamous cell carcinoma is the predominant type of esophageal carcinoma in China which carries a poor prognosis. In recent years

many reports have demonstrates that the environment where tumor cells live is closely related to the tumor progression. Tumor cells can be influenced by tumor microenvironment in ways such as regulation of immune microenvironment

production of cytokine and angiogenesis. Based on the several important ways in which esophageal squamous cell carcinoma tumor cells can be influenced including interleukin-6 (IL-6) programmed cell death protein 1/programmed cell death 1 ligand 1 (PD-1/ PD-L1)

transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF)

this article demonstrated the typical pathways and their impact on prognosis. The underlying mechanisms and related targeted therapies are also mentioned to enlighten the ongoing and future research.

关键词

Keywords

references

Views

4183

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mechanism of LINC01410 promoting proliferation and migration in esophageal squamous cell carcinoma

Advances in the application of co-culture strategies in organoids

Surgical treatment of esophagotracheal fistula caused by neoadjuvant chemotherapy for locally advanced esophageal cancer: a case report

Expression and clinical significance ofPLK4 gene in esophageal squamous cell carcinoma and its effect on cell proliferation, invasion and migration

Effects of docetaxel combined with thymosin α1 on number of Treg in immune microenvironment of rats with breast cancer and its mechanism

Related Author

Xiaohong KANG

Yabin GONG

Tingmin CHANG

Zidong MA

Xiaonan TANG

Wenhao YU

Fei CAO

Mingjuan LIAO

Related Institution

Department of Traditional Chinese Medicine, Shanghai Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine

Department of Science and Education, Pingdingshan First People’s Hospital

Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University

Department of Oncology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine

Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University

AI问答

⁰