The clinical significance of thyroglobulin antibody measurement in 131I therapy of differentiated thyroid carcinoma

林岩松

doi:10.19401/j.cnki.1007-3639.2019.06.009

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The clinical significance of thyroglobulin antibody measurement in 131I therapy of differentiated thyroid carcinoma

更新时间：2026-01-27

- The clinical significance of thyroglobulin antibody measurement in 131I therapy of differentiated thyroid carcinoma
- China Oncology Vol. 29, Issue 6, Pages: 452-456(2019)
- 作者机构：
  
  中国医学科学院北京协和医学院北京协和医院核医学科,北京,100730
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2019.06.009
  CLC： R736.1;R730.43
- Published Online：12 July 2019，
  
  Published：12 July 2019
- 稿件说明：
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张娜，林岩松，梁军. 甲状腺球蛋白抗体测定在分化型甲状腺癌

林岩松. The clinical significance of thyroglobulin antibody measurement in 131I therapy of differentiated thyroid carcinoma[J]. China Oncology, 2019, 29(6): 452-456.
张娜，林岩松，梁军. 甲状腺球蛋白抗体测定在分化型甲状腺癌 DOI： 10.19401/j.cnki.1007-3639.2019.06.009.

林岩松. The clinical significance of thyroglobulin antibody measurement in 131I therapy of differentiated thyroid carcinoma[J]. China Oncology, 2019, 29(6): 452-456. DOI： 10.19401/j.cnki.1007-3639.2019.06.009.

摘要

甲状腺球蛋白（thyroglobulin，Tg）是分化型甲状腺癌（differentiated thyroid carcinoma，DTC）患者治疗后随访的主要血清标志物，Tg的测定会受到甲状腺球蛋白抗体（thyroglobulin antibody，TgAb）的影响，限制了Tg作为肿瘤标志物在DTC随访中的作用。因此，有关TgAb阳性患者的随访一直是临床工作中的难题，有研究指出TgAb可以作为替补肿瘤标志物用于DTC的监测，但有关TgAb与DTC治疗后疾病状态与预后间的关系尚存争议。主要就TgAb在DTC患者

131

I治疗中的临床意义进行综述，以期为TgAb阳性患者的临床决策提供更多依据。

Abstract

Serum thyroglobulin (Tg) is a major tumor marker for follow-up after treatment of patients with differentiated thyroid carcinoma (DTC). However

the accuracy of Tg measurement is interfered by thyroglobulin antibody (TgAb)

limiting the predictive value of Tg. Therefore

the follow-up of DTCs with positive TgAb remains a clinical puzzlement. Some researchers have proposed that TgAb could also serve as a surrogate tumor marker for the monitoring of DTC

but it remains controversial over the relationship between TgAb and disease status or prognosis after treatment. This article reviewed the clinical significance of TgAb measurement i

131

I therapy of DTC

in order to provide more evidence for clinical decision making in patients with positive TgAb.

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