Diagnosis and treatment progress of metastatic cervical carcinoma with an unknown primary

陈嘉莹; 王卓颖

doi:10.19401/j.cnki.1007-3639.2019.06.010

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Diagnosis and treatment progress of metastatic cervical carcinoma with an unknown primary

更新时间：2026-01-27

- Diagnosis and treatment progress of metastatic cervical carcinoma with an unknown primary
- China Oncology Vol. 29, Issue 6, Pages: 457-462(2019)
- 作者机构：
  
  复旦大学附属肿瘤医院头颈外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2019.06.010
  CLC： R739.91
- Published Online：12 July 2019，
  
  Published：12 July 2019
- 稿件说明：
移动端阅览
陈嘉莹，王卓颖 . 原发不明的颈部转移性癌的诊治进展[J]. 中国癌症杂志, 2019, 29(6): 457-462.

陈嘉莹, 王卓颖. Diagnosis and treatment progress of metastatic cervical carcinoma with an unknown primary[J]. China Oncology, 2019, 29(6): 457-462.
陈嘉莹，王卓颖 . 原发不明的颈部转移性癌的诊治进展[J]. 中国癌症杂志, 2019, 29(6): 457-462. DOI： 10.19401/j.cnki.1007-3639.2019.06.010.

陈嘉莹, 王卓颖. Diagnosis and treatment progress of metastatic cervical carcinoma with an unknown primary[J]. China Oncology, 2019, 29(6): 457-462. DOI： 10.19401/j.cnki.1007-3639.2019.06.010.

摘要

原发不明的颈部转移性癌（metastatic cervical carcinoma with an unknown primary，MCCUP）是一类异质性的临床综合征。通过分析现有数据资料，阐述其诊断和治疗进展。PET/CT在探寻原发肿瘤病变方面有较高的诊断价值。内镜和分子生物学技术如miRNA分子表达谱分析、微卫星分析的应用也提高了MCCUP的诊断水平。手术和放射治疗是最主要的治疗方式，大部分医师赞成对于小于N

期的患者首选手术治疗。放疗仍占据重要地位，逆向调强放射治疗技术是治疗MCCUP的主流技术。

Abstract

Metastatic cervical carcinoma with an unknown primary (MCCUP) represents a heterogeneous group syndrome of cancers. The current data were analyzed

and the diagnosis and treatment progress of MCCUP were stated. Positron emission tomography computed/tomography(PET/CT) has a high value in the detection of primary tumors in patients with MCCUP. Panendoscopy and molecular testing

such as microRNA signatures and microsatellite analysis

also improve the diagnosis of MCCUP. Surgery and radiation therapy remain the main approaches of MCCUP treatment. Most doctors agree that surgery is the first choice for patients with N

1-2

disease. However

radiotherapy still plays an important role in the treatment of MCCUP. Today

salivary

preserving intensity-modulated radiation therapy has become the standard radiation technique for MCCUP.

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