The epigenetic regulation of histone methyltransferase SET8 in cancer

申雪芳; 晴; 许平波

doi:10.19401/j.cnki.1007-3639.2019.08.006

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The epigenetic regulation of histone methyltransferase SET8 in cancer

更新时间：2026-01-27

- The epigenetic regulation of histone methyltransferase SET8 in cancer
- China Oncology Vol. 29, Issue 8, Pages: 595-598(2019)
- 作者机构：
  
  复旦大学附属肿瘤医院麻醉科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2019.08.006
  CLC： R730.2
- Published Online：29 September 2019，
  
  Published：29 September 2019
- 稿件说明：
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申雪芳，花?晴,许平波? . 组蛋白单甲基转移酶SET8在肿瘤中的调节作用[J]. 中国癌症杂志, 2019, 29(8): 595-598.

申雪芳, 晴, 许平波. The epigenetic regulation of histone methyltransferase SET8 in cancer[J]. China Oncology, 2019, 29(8): 595-598.
申雪芳，花?晴,许平波? . 组蛋白单甲基转移酶SET8在肿瘤中的调节作用[J]. 中国癌症杂志, 2019, 29(8): 595-598. DOI： 10.19401/j.cnki.1007-3639.2019.08.006.

申雪芳, 晴, 许平波. The epigenetic regulation of histone methyltransferase SET8 in cancer[J]. China Oncology, 2019, 29(8): 595-598. DOI： 10.19401/j.cnki.1007-3639.2019.08.006.

摘要

SET8（PR-set7、SETD8或KMT5A）是目前发现的唯一的组蛋白H4赖氨酸20单甲基转移酶，调节细胞周期的正常运转。SET8的异常表达能够促进肿瘤的增殖、侵袭和转移，可预测肿瘤的不良预后。同时，SET8还能影响肿瘤的能量代谢，促进肿瘤的发生、发展。现就SET8在肿瘤中的作用予以综述，探讨其调控机制及靶向治疗的前景。

Abstract

SET8 (PR-set7

SETD8 or KMT5A) is the only histone monomethylation transferase targeting H4K20

which is an important regulator of cell cycle. The abnormal transcription of SET8 leads to tumorigenesis

invasion and metastasis

and is associated with the poor prognosis. Meanwhile

the abnormal transcription of SET8 also regulates energetic metabolism in cancer to promote tumor progression. This review described the function of SET8 in tumor. And only when we know the mechanism deeply

can we use it to guide tumor diagnosis. New medicine targeting SET8 for tumor therapy is anticipated.

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