Survival report of 13.7 thousand surgical colorectal cancer patients from a large single hospital-based cancer registry

周昌明; 郭天安; 莫　淼; 袁　晶; 沈　洁; 王泽洲; 黄　丹; 朱　骥; 李心翔; 蔡国响; 徐　烨; 蔡三军; 郑　莹

doi:10.19401/j.cnki.1007-3639.2020.04.002

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Survival report of 13.7 thousand surgical colorectal cancer patients from a large single hospital-based cancer registry

更新时间：2026-01-27

- Survival report of 13.7 thousand surgical colorectal cancer patients from a large single hospital-based cancer registry
- China Oncology Vol. 30, Issue 4, Pages: 246-253(2020)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院肿瘤预防部，复旦大学上海医学院肿瘤学系,上海,200032
  2. 复旦大学附属肿瘤医院大肠外科，复旦大学上海医学院肿瘤学系,上海,200032
  3. 复旦大学附属肿瘤医院病理科，复旦大学上海医学院肿瘤学系,上海,200032
  4. 复旦大学附属肿瘤医院放射治疗科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2020.04.002
  CLC： R735.34
- Published Online：11 May 2020，
  
  Published：11 May 2020
- 稿件说明：
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周昌明, 郭天安, 莫　淼, 袁　晶, 沈　洁, 王泽洲, 黄　丹, 朱　骥, 李心翔, 蔡国响, 徐　烨, 蔡三军, 郑　莹 . 以大型单中心医院登记为基础的1.37万例结直肠癌手术患者生存报告[J]. 中国癌症杂志, 2020, 30(4): 246-253.

周昌明, 郭天安, 莫　淼, et al. Survival report of 13.7 thousand surgical colorectal cancer patients from a large single hospital-based cancer registry[J]. China Oncology, 2020, 30(4): 246-253.
周昌明, 郭天安, 莫　淼, 袁　晶, 沈　洁, 王泽洲, 黄　丹, 朱　骥, 李心翔, 蔡国响, 徐　烨, 蔡三军, 郑　莹 . 以大型单中心医院登记为基础的1.37万例结直肠癌手术患者生存报告[J]. 中国癌症杂志, 2020, 30(4): 246-253. DOI： 10.19401/j.cnki.1007-3639.2020.04.002.

周昌明, 郭天安, 莫　淼, et al. Survival report of 13.7 thousand surgical colorectal cancer patients from a large single hospital-based cancer registry[J]. China Oncology, 2020, 30(4): 246-253. DOI： 10.19401/j.cnki.1007-3639.2020.04.002.

摘要

背景与目的：基于医院登记为基础的结直肠癌手术患者的随访资料，分析其1、3和5年总生存率（overall survival，OS）与无病生存率（disease-free survival，DFS），为了解中国结直肠癌患者长期生存情况提供真实世界研究证据。方法：研究纳入2008年1月1日—2017年12月31日在复旦大学附属肿瘤医院接受手术治疗的结直肠癌患者共13 721例，通过查阅患者复诊病史、电话随访和死因数据链接等方式收集患者的生存随访资料，随访统计时间截至2019年11月30日。采用Kaplan-Meier法估计患者1、3和5年OS和DFS，根据年龄组、性别、治疗时期、肿瘤分期以及病理学特征、治疗方式各亚组分别描述。结果：结直肠癌手术患者经中位54.03个月随访后，5年OS和0~Ⅲ期患者5年DFS分别为73.87%和72.25%。0~Ⅰ、Ⅱ、Ⅲ和Ⅳ期结直肠癌手术患者5年OS分别为91.92%、87.15%、70.49%和27.70%，45岁以下年龄组患者5年OS为74.93%，差于45~64岁和65~74岁年龄组。不同组织学类型、分化程度、壁外血管侵犯、神经侵犯、环切缘情况患者的生存差异显著。结论：首次报告中国国内单中心超万人结直肠癌患者的5年长期生存结果，44岁及以下青年结直肠癌患者生存率较低，肿瘤分期是影响结直肠癌患者生存的重要可改变因素，应加强早诊早治，进一步提升患者生存率。

Abstract

Background and purpose: The study analyzed 1-

3- and 5-year observed overall survival (OS) and disease-free survival (DFS)

providing real world evidence of long-term survival among Chinese surgical colorectal cancer patients. Methods: A total of 13 721 colorectal cancer patients undergoing surgery in Fudan University Shanghai Cancer Center (FUSCC) from Jan. 1

2008 to Dec. 31

2017 were included in the analysis. Medical records review

telephone visits and death registry data linkage were carried out for collecting endpoint data. The last follow-up date was Nov. 30

2019. Kaplan-Meier method was used to evaluate the 1-

and 5-year OS and DFS

and data were stratified by age group

gender

staging

calendar period

pathological characteristics and treatment approaches. Results: With a median follow-up time of 54.03 months

the 5-year OS of all patients and DFS of 0-Ⅲ stage surgical colorectal cancer patients were 73.87% and 72.25%

respectively. The 5-year OS of stage 0-Ⅰ

Ⅱ

Ⅲ and Ⅳ colorectal cancer patients were 91.92%

87.15%

70.49% and 27.70%

respectively. The OS of patients aged less than 45 years was 74.93%

poorer than 45-64 and 65-74 age category. There were significant difference in OS and DFS among different histology types

differentiation

extermural vascular invasion

perineural invasion and circumferential radial margin. Conclusion: It is the first single institutional long term survival report of over 10 thousand colorectal cancer patients. Young patients aged less than 45 years had a poor prognosis. Staging is an important modifiable factor

which implies that enhancing screening and early diagnosis has important meaning to further improve the patients’ survival.

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