Research progress and clinical significance of breast cancer heterogeneity

蒋梦怡; 陆言巧; 王红霞

doi:10.19401/j.cnki.1007-3639.2020.05.012

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Research progress and clinical significance of breast cancer heterogeneity

更新时间：2026-01-27

- Research progress and clinical significance of breast cancer heterogeneity
- China Oncology Vol. 30, Issue 5, Pages: 394-400(2020)
- 作者机构：
  
  1. 南京医科大学附属上海一院临床医学院肿瘤科,上海,200080
  2. 上海交通大学附属胸科医院心内科,上海,200030
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2020.05.012
  CLC： R737.9
- Published Online：09 June 2020，
  
  Published：09 June 2020
- 稿件说明：
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蒋梦怡 , 陆言巧 , 王红霞 . 乳腺癌异质性的研究进展及临床意义[J]. 中国癌症杂志, 2020, 30(5): 394-400.

蒋梦怡, 陆言巧, 王红霞. Research progress and clinical significance of breast cancer heterogeneity[J]. China Oncology, 2020, 30(5): 394-400.
蒋梦怡 , 陆言巧 , 王红霞 . 乳腺癌异质性的研究进展及临床意义[J]. 中国癌症杂志, 2020, 30(5): 394-400. DOI： 10.19401/j.cnki.1007-3639.2020.05.012.

蒋梦怡, 陆言巧, 王红霞. Research progress and clinical significance of breast cancer heterogeneity[J]. China Oncology, 2020, 30(5): 394-400. DOI： 10.19401/j.cnki.1007-3639.2020.05.012.

摘要

异质性是乳腺癌的重要特征之一。尽管多数研究认为乳腺癌为单克隆起源，但由于发生、发展过程中多次分裂增殖、不断进化，表观遗传、基因组学及微环境改变导致细胞具有不同表型及生物学特征，从而产生异质性，表现为不同的组织学类型、分化程度、细胞增殖速率、侵袭转移能力及治疗反应性等诸多方面。乳腺癌个体化医疗的精准实施要求考虑到不同分子亚型以及同一个肿瘤组织内不同细胞亚群的存在。就乳腺癌异质性的起源、分类、表型特点及临床意义等研究进展进行综述。

Abstract

Heterogeneity is one of the characteristics of breast cancer. Although most of the studies agree with the monoclonal origin of spontaneous tumor

due to multiple division and proliferation

epigenetic and genomic changes in the process of occurrence and development

cells present different phenotypes and biological characteristics. These differences are reflected in tissue type

differentiation degree

cell proliferation rate

invasion and metastasis abilities

therapeutic response and many other aspects. The precise implementation of individualized medical treatment must treat the different molecular types represented by different histology and molecular characteristics differently and consider the existence of different cell subsets in the same tumor tissue. This article reviewed the mechanism and research progress of breast cancer heterogeneity in order to facilitate the clinical development of breast cancer precision medicine.

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