Advances in research of exosomes as targeted therapeutic vectors

潘星昊; 刘明斌; 张晓燕; 徐建青

doi:10.19401/j.cnki.1007-3639.2020.09.010

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Advances in research of exosomes as targeted therapeutic vectors

更新时间：2026-01-27

- Advances in research of exosomes as targeted therapeutic vectors
- China Oncology Vol. 30, Issue 9, Pages: 701-706(2020)
- 作者机构：
  
  复旦大学附属公共卫生临床中心,上海,201508
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2020.09.010
  CLC： R730.5
- Published Online：13 October 2020，
  
  Published：13 October 2020
- 稿件说明：
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潘星昊, 刘明斌, 张晓燕, 徐建青. 外泌体作为靶向治疗载体的研究进展[J]. 中国癌症杂志, 2020, 30(9): 701-706.

潘星昊, 刘明斌, 张晓燕, et al. Advances in research of exosomes as targeted therapeutic vectors[J]. China Oncology, 2020, 30(9): 701-706.
潘星昊, 刘明斌, 张晓燕, 徐建青. 外泌体作为靶向治疗载体的研究进展[J]. 中国癌症杂志, 2020, 30(9): 701-706. DOI： 10.19401/j.cnki.1007-3639.2020.09.010.

潘星昊, 刘明斌, 张晓燕, et al. Advances in research of exosomes as targeted therapeutic vectors[J]. China Oncology, 2020, 30(9): 701-706. DOI： 10.19401/j.cnki.1007-3639.2020.09.010.

摘要

外泌体是来源于细胞内膜的纳米级的囊泡，包含有核酸、蛋白和脂质等生命物质，作为一种细胞间交流的机制，在生命活动中发挥着重要作用。相对于脂质体载体，外泌体更稳定，生物相容性好，免疫原性低，而且可以渗透生物屏障，例如血脑屏障、胎盘屏障等。重点介绍外泌体载体靶向性的基础、外泌体载体装载负荷的方法及外泌体载体目前的应用进展和前景。

Abstract

Exosomes are nanoscale vesicles derived from the inner membrane of cells

containing life information such as nucleic acids

proteins and lipids. They play an important role in life activities as a mechanism of intercellular communication. Compared to liposome carriers

exosomes are more stable

biocompatible and less immunogenic

and can penetrate biological barriers such as the blood-brain barrier and the placental barrier. This article focused on the basis of exosome vector targeting

the method of carrier loading and the current application progress and prospects.

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