Application and research progress of selective internal radiation therapy with<sup>90</sup>Y microspheres in hepatocellular carcinoma

牛　娜; 林岩松

doi:10.19401/j.cnki.1007-3639.2021.05.009

您当前的位置：

首页 >

文章列表页 >

Application and research progress of selective internal radiation therapy with⁹⁰Y microspheres in hepatocellular carcinoma

更新时间：2026-01-27

- Application and research progress of selective internal radiation therapy with⁹⁰Y microspheres in hepatocellular carcinoma
- China Oncology Vol. 31, Issue 5, Pages: 428-434(2021)
- 作者机构：
  
  中国医学科学院北京协和医学院北京协和医院核医学科,北京,100730
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2021.05.009
  CLC： R735.7
- Published Online：31 May 2021，
  
  Published：31 May 2021
- 稿件说明：
移动端阅览
牛　娜, 林岩松 .

牛　娜, 林岩松. Application and research progress of selective internal radiation therapy with⁹⁰Y microspheres in hepatocellular carcinoma[J]. China Oncology, 2021, 31(5): 428-434.
牛　娜, 林岩松 . DOI： 10.19401/j.cnki.1007-3639.2021.05.009.

牛　娜, 林岩松. Application and research progress of selective internal radiation therapy with⁹⁰Y microspheres in hepatocellular carcinoma[J]. China Oncology, 2021, 31(5): 428-434. DOI： 10.19401/j.cnki.1007-3639.2021.05.009.

摘要

肝细胞癌（hepatocellular carcinoma，HCC）是中国癌症相关死亡第二大常见原因。中国约85%的HCC患者在确诊时已是中晚期，系统治疗（包括化疗、靶向治疗、免疫治疗）联合局部微创治疗（如介入治疗、放射治疗等）是目前主要的治疗方式。钇-90（yttrium-90，

Y）微球选择性内放射治疗（selective internal radiation therapy，SIRT）作为主要局部微创治疗手段在国外已有近20年的临床使用经验，临床研究证明了其治疗肝脏肿瘤的疗效和安全性。相关研究证实了

Y微球SIRT单用在HCC中的局部控制作用，以及其与手术、免疫药物、靶向药物联用的有效性及安全性，同时，

Y微球SIRT对于肝段产生的“放射性切除”效应初步显示出其在HCC根治性治疗方面的应用前景。从HCC姑息治疗、转化治疗、放射性肝段切除等方面综述SIRT在HCC中的应用及研究进展。

Abstract

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related deaths in China. About 85% of HCC patients are at intermediate or advanced stage upon diagnosis

of which the common treatment strategy is the combination of systemic therapy (including chemotherapy

targeted therapy and immunotherapy) and local minimally invasive therapy (such as interventional therapy and radiotherapy). As one of the local minimally invasive treatment modalities

selective internal radiation thera

py (SIRT) with yttrium-90 (

Y) microspheres has been used for nearly 20 years abroad with confirmed efficacy and safety. Benefit in local control of HCC by using SIRT with

Y microspheres alone or being combined with surgery

immunotherapy and targeted drugs has been demonstrated. Meanwhile

the “radiation resection” effect of SIRT with

Y microsphere on liver segments sheds light on its promising clinical use as radical treatment for HCC. Herein

the application and recent progress of SIRT with

Y microspheres in HCC were reviewed in terms of its therapeutic purpose as palliative

transformation or radiation segmentectomy.

关键词

Keywords

references

Views

2663

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

PARP1 promotes the progression of hepatocellular carcinoma by regulating expression of POU2F2

Significance of infiltration of M1 tumor-associated macrophages in hepatocellular carcinoma

Progress in research, diagnosis, and treatment of hepatocellular carcinoma in 2022

Mechanism of LINC00601 in regulating sensitivity of hepatocellular carcinoma cells to oxaliplatin chemotherapy

Plasma exosomal CD48 protein as a candidate diagnostic biomarker for hepatocellular carcinoma

Related Author

Ziqiang WEN

Junliang LAN

Bo ZHOU

Qiwei XU

Feng XIAO

Tonglin XU

Lin ZHU

Jingwen XIAO

Related Institution

Department of Hepatobiliary Surgery, Linfen People’s Hospital, The Seventh Clinical Medical College of Shanxi Medical University

Clinical Medicine, Major of Medical College Nantong University

Department of Pathology, the Third People's Hospital of Nantong, Affiliated Nantong Hospital Three of Nantong University

Department of Surgery, the Third People’s Hospital of Nantong, Affiliated Nantong Hospital Three of Nantong University

Liver Cancer Institute, Zhongshan Hospital, Fudan University

AI问答

⁰

Application and research progress of selective internal radiation therapy with90Y microspheres in hepatocellular carcinoma

DOI：10.19401/j.cnki.1007-3639.2021.05.009

摘要

Abstract

关键词

Keywords

references

Application and research progress of selective internal radiation therapy with⁹⁰Y microspheres in hepatocellular carcinoma