Research status and progress of mechanism of T cell immune metabolism and its application combined with immune checkpoint inhibitor

李　崴; 张山岭; 陶英杰; 王旭东

doi:10.19401/j.cnki.1007-3639.2021.07.011

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Research status and progress of mechanism of T cell immune metabolism and its application combined with immune checkpoint inhibitor

更新时间：2025-12-31

- Research status and progress of mechanism of T cell immune metabolism and its application combined with immune checkpoint inhibitor
- China Oncology Vol. 31, Issue 7, Pages: 640-646(2021)
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- DOI：10.19401/j.cnki.1007-3639.2021.07.011
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- Published Online：04 August 2021，
  
  Published：04 August 2021
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李　崴, 张山岭, 陶英杰, 王旭东. T细胞免疫代谢调控与免疫检查点抑制剂联合应用的现状及研究进展[J]. 中国癌症杂志, 2021, 31(7): 640-646.

李　崴, 张山岭, 陶英杰, et al. Research status and progress of mechanism of T cell immune metabolism and its application combined with immune checkpoint inhibitor[J]. China Oncology, 2021, 31(7): 640-646.
李　崴, 张山岭, 陶英杰, 王旭东. T细胞免疫代谢调控与免疫检查点抑制剂联合应用的现状及研究进展[J]. 中国癌症杂志, 2021, 31(7): 640-646. DOI： 10.19401/j.cnki.1007-3639.2021.07.011.

李　崴, 张山岭, 陶英杰, et al. Research status and progress of mechanism of T cell immune metabolism and its application combined with immune checkpoint inhibitor[J]. China Oncology, 2021, 31(7): 640-646. DOI： 10.19401/j.cnki.1007-3639.2021.07.011.

摘要

近年来免疫检查点抑制剂（immune checkpoint inhibitor，ICI）已广泛应用于多种恶性肿瘤的治疗，但由于其单药客观缓解率较低，部分瘤种仅10%~20%，因此ICI联合用药成为近期研究热点。研究表明，肿瘤特殊的代谢方式及产物可以调控T细胞的分化和功能，而细胞代谢调节药物可以使T细胞在肿瘤微环境（tumor microenvironment，TME）中寿命延长及功能增强，联合ICI提高其治疗效果。拟对T细胞免疫代谢调控机制，TME和ICI对T细胞免疫代谢的影响，以及细胞代谢药物联合ICI的研究进展进行综述。

Abstract

Cancer immunotherapy based on immune checkpoint inhibitor (ICI) has been widely developed. However

due to the low objective response rate of ICI monotherapy

only 10%-20% in some tumors

ICI combination therapy has become a research highlight recently. Studies have shown that cancer metabolism and its products can regulate the differentiation and function of T cells. Regulating cell metabolism can prolong the longevity and enhance the function of T cells in the tumor microenvironment (TME)

and the combination of ICI can improve its therapeutic effect. Here

we summarized the differentiation of T cells regulated by immune metabolism

the effects of TME and ICI on T cell immune metabolism

and research progresses on the role of combination of cell metabolism drugs and ICI in cancer immunotherapy.

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Department of Medical Oncology, Zhongshan Hospital, Fudan University

Department of Pharmacy, Zhongshan Hospital, Fudan University

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