New progress and prospect of breast cancer bone metastasis research from mechanism to clinic

Jiahui WANG; Linlan JIANG; Zan SHEN

doi:10.19401/j.cnki.1007-3639.2022.02.009

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New progress and prospect of breast cancer bone metastasis research from mechanism to clinic

更新时间：2025-12-31

- New progress and prospect of breast cancer bone metastasis research from mechanism to clinic
- China Oncology Vol. 32, Issue 2, Pages: 172-176(2022)
- 作者机构：
  
  上海交通大学附属第六人民医院肿瘤内科,上海 200233
- 作者简介：
  
  SHEN Zan E-mail: sshenzzan@vip.sina.com
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.02.009
  CLC： R737.9
- Received：30 May 2021，
  
  Published：28 February 2022
- 稿件说明：
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Jiahui WANG, Linlan JIANG, Zan SHEN. New progress and prospect of breast cancer bone metastasis research from mechanism to clinic[J]. China Oncology, 2022, 32(2): 172-176.
DOI：

Jiahui WANG, Linlan JIANG, Zan SHEN. New progress and prospect of breast cancer bone metastasis research from mechanism to clinic[J]. China Oncology, 2022, 32(2): 172-176. DOI： 10.19401/j.cnki.1007-3639.2022.02.009.

摘要

乳腺癌骨转移是晚期乳腺癌患者严重的并发症之一。骨转移后出现的严重骨痛、病理性骨折等并发症

严重影响患者的生活质量并缩短其生存期。近年来

随着对乳腺癌骨转移机制以及肿瘤细胞与骨微环境之间相关调控网络的认知不断深入

许多新药的开发和应用使乳腺癌骨转移的治疗取得重大进展。现就乳腺癌骨转移机制及目前治疗研究进展进行综述。

Abstract

Bone metastasis is one of the most serious complications in advanced breast cancer patients. Severe osteodynia

pathological fracture and other complications in bone metastasis of breast cancer can seriously affect the quality of life and shorten life span. In recent years

with the further understanding of the mechanism of bone metastases and the cross-talk between tumor cells and bone microenvironment

development and application of many new effective drugs have made significant progress in the treatment of bone metastasis of breast cancer. This article reviewed the mechanism of bone metastasis of breast cancer and current treatment advances.

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references

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Guidelines for breast cancer diagnosis and treatment by China Anti-Cancer Association (2026 edition)

Construction of the prediction model of breast cancer bone metastasis based on machine learning

Guidelines for breast cancer diagnosis and treatment by China Anti-cancer Association (2024 edition)

Chinese consensus of cardio-oncology in breast cancer

Chinese expert consensus recommendations for management of bone health in female patients with early breast cancer (2022 edition)

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Related Institution

Department of Orthopaedics, The First Affiliated Hospital of Air Force Medical University, Xi 'an

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Department of Breast Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

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