Analysis of risk factors of early recurrence and metastasis after radical resection of gastric cancer

Mengxuan CAO; Can HU; Yanqiang ZHANG; Ling HUANG; Yian DU; Pengcheng YU; Ruolan ZHANG; Zhiyuan XU; Xiangdong CHENG

doi:10.19401/j.cnki.1007-3639.2022.07.002

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Analysis of risk factors of early recurrence and metastasis after radical resection of gastric cancer

Specialists' Article | 更新时间：2025-12-31

- Analysis of risk factors of early recurrence and metastasis after radical resection of gastric cancer
- China Oncology Vol. 32, Issue 7, Pages: 588-595(2022)
- 作者机构：
  
  1. 中国科学院大学附属肿瘤医院（浙江省肿瘤医院）胃外科,中国科学院基础医学与肿瘤研究所,浙江杭州 310005
  2. 温州医科大学,浙江省肿瘤医院研究生培养基地,浙江温州 325035
  3. 浙江中医药大学第一临床医学院,浙江杭州 310053
  4. 浙江中医药大学第二临床医学院,浙江杭州 310053
- 作者简介：
  
  XU Zhiyuan, E-mail: xuzy@zjcc.org.cn;
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.07.002
  CLC： R735.2
- Received：02 June 2022，
  
  Published：30 July 2022
- 稿件说明：
移动端阅览
Mengxuan CAO, Can HU, Yanqiang ZHANG, et al. Analysis of risk factors of early recurrence and metastasis after radical resection of gastric cancer[J]. China Oncology, 2022, 32(7): 588-595.
DOI：

Mengxuan CAO, Can HU, Yanqiang ZHANG, et al. Analysis of risk factors of early recurrence and metastasis after radical resection of gastric cancer[J]. China Oncology, 2022, 32(7): 588-595. DOI： 10.19401/j.cnki.1007-3639.2022.07.002.

摘要

背景与目的：

目前胃癌仍是癌症死亡的重要原因

其术后复发是导致胃癌患者生存率较低的主要因素。本研究旨在探讨胃癌患者术后早期、晚期复发转移与临床病理学特征的关系

以便更好地改善胃癌预后。

方法：

回顾性分析2014年1月

#x02014;2016年1月在浙江省肿瘤医院行胃癌根治性手术后出现复发转移的188例胃癌患者的临床病理学资料

比较早期复发转移患者（

#x02264;2年）与晚期复发转移患者（

2年）的临床病理学特征的差异。

结果：

188例患者中

126例患者出现早期复发

62例患者出现晚期复发

总体中位复发时间为术后18个月。复发部位、淋巴结转移、浆膜浸润、无术前新辅助化疗、无术后辅助化疗及低分化是胃癌术后早期复发的独立危险因素。

结论：

复发部位、术前新辅助化疗、术后辅助化疗、淋巴结转移、浸润深度及组织分化程度与术后复发有关。

Abstract

Background and purpose:

At present

gastric cancer is still an important cause of cancer death

and its postoperative recurrence is the main factor leading to the low survival rate of gastric cancer. The purpose of this study was to investigate the relationship between early and late postoperative recurrence and metastasis and clinicopathological features in patients with gastric cancer in order to improve the prognosis of gastric cancer.

Methods:

The clinicopathological data of 188 patients with recurrent and metastatic gastric cancer after radical operation in Zhejiang Cancer Hospital from January 2014 to January 2016 were analyzed retrospectively. The clinicopathological characteristics of patients with early recurrence and metastasis (

#x02264;2 years) and late recurrence and metastasis (

2 years) were compared.

Results:

Among the 188 patients

126 patients had early recurrence and 62 patients had late recurrence. The overall median time of recurrence was 18 months after operation. Recurrence site

lymph nod

e metastasis

serosa infiltration

no preoperative neoadjuvant chemotherapy

no postoperative adjuvant chemotherapy and poor differentiation are independent risk factors for early postoperative recurrence of gastric cancer.

Conclusion:

The location of recurrence

preoperative neoadjuvant chemotherapy

postoperative adjuvant chemotherapy

lymph node metastasis

depth of invasion and degree of tissue differentiation are related to postoperative recurrence.

关键词

Keywords

references

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