Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version)

Society of Cancer Multidisciplinary Diagnosis and Treatment, China Anti-Cancer Association The; Society of Cancer Endocrinology, China Anti-Cancer Association The

doi:10.19401/j.cnki.1007-3639.2022.07.010

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Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version)

Guideline and Consensus | 更新时间：2025-12-31

- Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version)
- China Oncology Vol. 32, Issue 7, Pages: 657-668(2022)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.07.010
  CLC： R73-3
- Received：10 June 2022，
  
  Published：30 July 2022
- 稿件说明：
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Society of Cancer Multidisciplinary Diagnosis and Treatment, China Anti-Cancer Association The, Society of Cancer Endocrinology, China Anti-Cancer Association The. Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version)[J]. China Oncology, 2022, 32(7): 657-668.
DOI：

Society of Cancer Multidisciplinary Diagnosis and Treatment, China Anti-Cancer Association The, Society of Cancer Endocrinology, China Anti-Cancer Association The. Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version)[J]. China Oncology, 2022, 32(7): 657-668. DOI： 10.19401/j.cnki.1007-3639.2022.07.010.

摘要

近年来

类器官技术的发展为开发新的、更接近真实病理生理学状态的人类癌症模型开辟了新途径。源自患者的肿瘤类器官保留了原始肿瘤的组织病理学特征、遗传特征和分子生物学特征等表型

不仅可作为识别和测试新型抗癌药物的优良模型

也可通过肿瘤类器官的药物敏感性检测反馈患者的临床反应

为肿瘤患者的个体化精准治疗提供可靠的依据。然而

与传统的组织样本库相比

活体类器官生物库的建立需要更严格的质量控制和更高水平的技术标准。随着类器官研究的不断深入

肿瘤类器官已广泛覆盖多种实体瘤

类器官技术亦在2017年被评为生命科学领域年度技术

但国内对肿瘤类器官构建、鉴定及药物敏感性检测尚无质量控制标准

同时亦缺乏肿瘤类器官用于精准治疗的专家共识。因此

根据全球范围内多个团队基于患者来源的肿瘤类器官的药物敏感性检测在肿瘤精准治疗中已发表的研究数据

中国抗癌协会肿瘤多学科诊疗专业委员会、中国抗癌协会肿瘤内分泌专业委员会针对肿瘤类器官药物敏感性检测的临床应用与质量控制制订了《肿瘤类器官诊治平台的质量控制标准中国专家共识（2022年版）》

希望通过本共识

提高中国临床工作者及医学研究者对于类器官药物敏感性检测的认识

规范类器官诊治平台的质量控制

指导类器官药物敏感性检测在国内肿瘤精准治疗方案选择中的临床应用。本共识将根据未来开展的基于类器官的各项研究成果定期更新。

Abstract

Recently

advances in organoid technology have opened new avenues for the development of novel models of human cancer. Patient-derived tumor organoids retain phenotypes such as histopathological

genetic and molecular features of the original tumor. The generation of cancer

more closer to the real pathophysiological status organoids from primary patient material enables a range of therapeutic agents to be tested in the resulting organoid cultures that not only can be an excellent and innovative platform for drug discovery

but also through sensitivity test of the drug candidates can predict patient response to therapy

thereby holding great promise for personalized medicine. However

compared to traditional biobanks

living biobanks from patient-derived organoids requires stricter quality control and higher level of technical standards. With further research of organoids

a variety of solid tumors have been covered. Organoid technology was named technology of the year in life sciences in 2017. There is no quality control standard for the construction

identification and drug-screening applications of patient-derived cancer organoids in China

and there is also a lack of experts consensus for drug sensitivity test to guide precise tumor treatment. Therefore

based on the advances of patient-derived tumor organoids at home and abroad in the precision medicine

the Multidisciplinary Diagnosis and Treatment Professional Committee of China Anti-cancer Association and the Tumor Endocrinology Professional Committee of China Anti-cancer Association have formulated “Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version)”

which improves the understanding of Chinese clinicians and medical researchers on organoids’ drug sensitivity test

standardizes the quality of tumor organoids diagnosis and treatment platform

and guide its clinical application in the domestic precision medicine. This consensus will be regularly updated based on the further research on organoids.

关键词

Keywords

references

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