Analysis of therapeutic response of iodine positive metastasis lymph nodes in differentiated thyroid cancer after <sup>131</sup>I treatment

Xiaoran MEI; Fang FENG; Hui WANG; Zhixiao WEI

doi:10.19401/j.cnki.1007-3639.2022.11.007

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Analysis of therapeutic response of iodine positive metastasis lymph nodes in differentiated thyroid cancer after ¹³¹I treatment

Article | 更新时间：2025-12-31

- Analysis of therapeutic response of iodine positive metastasis lymph nodes in differentiated thyroid cancer after ¹³¹I treatment
- China Oncology Vol. 32, Issue 11, Pages: 1091-1097(2022)
- 作者机构：
  
  1. 广西医科大学第一附属医院核医学科，广西南宁 530021
  2. 上海交通大学医学院附属新华医院核医学科，上海 200092
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.11.007
  CLC： R736.1
- Received：31 May 2022，
  
  Revised：2022-08-17，
  
  Published：30 November 2022
- 稿件说明：
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Xiaoran MEI, Fang FENG, Hui WANG, et al. Analysis of therapeutic response of iodine positive metastasis lymph nodes in differentiated thyroid cancer after ¹³¹I treatment[J]. China Oncology, 2022, 32(11): 1091-1097.
DOI：

Xiaoran MEI, Fang FENG, Hui WANG, et al. Analysis of therapeutic response of iodine positive metastasis lymph nodes in differentiated thyroid cancer after ¹³¹I treatment[J]. China Oncology, 2022, 32(11): 1091-1097. DOI： 10.19401/j.cnki.1007-3639.2022.11.007.

摘要

背景与目的：

淋巴结转移（lymph node metastasis，LNM）是分化型甲状腺癌（differentiated thyroid carcinoma，DTC）最常见的转移，而

131

I对LNM的疗效存在争议，本研究旨在明确

131

I对摄碘良好的LNM的疗效及影响因素。

方法：

纳入2015年1月—2019年6月在上海交通大学医学院附属新华医院接受

131

I治疗的90例DTC患者，共计161个摄碘阳性的转移淋巴结。分析患者的临床及影像学资料，应用SPSS 24.0软件进行统计分析。计量资料按照正态分布，进行独立样本

检验比较，计数资料的比较采用

检验，用logistic回归进行多因素分析，建立多个定量指标与结局为

131

I治疗无效的关系间的受试者工作特征（receiver operating characteristic，ROC）曲线，并得到最佳诊断阈值。

结果：

161个摄碘阳性的转移淋巴结中，有效组为71个（44.10%），无效组为90个（55.90%）。单因素分析提示，两组患者在年龄、性别、病理学类型、原发病灶数量、原发病灶位置、有无远处转移及血清甲状腺球蛋白（thyroglobulin，Tg）水平等方面差异均有统计学意义（

0.05）。多变量logistic回归分析显示，病理学类型（OR = 11.827，95% CI：1.128 ~ 123.978，

= 0.039）、有无远处转移（OR = 0.220，95% CI：0.093 ~ 0.522，

= 0.001）和原发病灶数量（OR = 0.421，95% CI：0.212 ~ 0.837，

= 0.014）与治疗后的转归密切相关。

结论：

原发病灶多灶、病理学类型为甲状腺乳头状癌（papillary thyroid carcinoma，PTC）、远处转移、血清Tg高于43.51 ng/mL及转移淋巴结的最大径大于16.8 mm是摄碘阳性淋巴结

131

I治疗无效的危险因素，建议对此类患者加大治疗剂量或尽早选择手术切除。

Abstract

Background and purpose:

Lymph node metastasis (LNM) is the most common metastasis of differentiated thyroid cancer (DTC)

and the efficacy of

131

I on LNM is controversial. The aim of this study was to clarify the efficacy of

131

I on LNM with good iodine uptake and the influencing factors.

Methods:

In this study

161 iodine positive metastasis lymph nodes from 90 DTC patients treated by

131

I from January 2015 to June 2019 in Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine were included

and the clinical and imaging data of the patients were analyzed. SPSS 24.0 software was used to make statistical analysis. The measurement data were distributed according to the normal distribution

then the independent sample

-test was compared. The comparison of

the counting data was conducted by

test

and the multivariate analysis was carried out by logistic regression analysis. The receiver operating characteristic (ROC) curve between multiple quantitative indexes and the failure of

131

I treatment were established

and the optimal diagnostic threshold was obtained.

Results:

Among 161 iodine positive metastasis lymph nodes

71 (44.10%) were effective

and 90 (55.90%) were ineffective. Univariate analysis showed that there were significant differences in age

gender

pathological type

number of primary lesions

location of primary lesions

distant metastasis and serum thyroglobulin (Tg) level between the two groups (

0.05). Multivariate logistic regression analysis showed that the pathological types (OR = 11.827

95% CI: 1.128-123.978

= 0.039)

distant metastasis (OR = 0.220

95% CI: 0.093-0.522

= 0.001) and number of primary lesions (OR = 0.421

95% CI: 0.212-0.837

= 0.014) were closely related to the outcome of the treatment.

Conclusion:

Multiple primary foci

papillary thyroid carcinoma (PTC)

distant metastasis

serum Tg higher than 43.51 ng/mL and the maximum diameter of metastatic lymph nodes greater than 16.8mm are the risk factors of ineffective

131

I treatment. Increasing the treatment dose or choosing surgical resection as soon as possible is recommended for those patients.

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Keywords

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Analysis of therapeutic response of iodine positive metastasis lymph nodes in differentiated thyroid cancer after 131I treatment

DOI：10.19401/j.cnki.1007-3639.2022.11.007

摘要

Abstract

关键词

Keywords

references

Analysis of therapeutic response of iodine positive metastasis lymph nodes in differentiated thyroid cancer after ¹³¹I treatment