Progress in diagnosis and treatment of gynecological tumors in 2022

Qinhao GUO; Min YU; Xiaohua WU

doi:10.19401/j.cnki.1007-3639.2023.01.002

您当前的位置：

首页 >

文章列表页 >

Progress in diagnosis and treatment of gynecological tumors in 2022

Specialists' Commentary | 更新时间：2025-12-31

- Progress in diagnosis and treatment of gynecological tumors in 2022
- China Oncology Vol. 33, Issue 1, Pages: 14-24(2023)
- 作者机构：
  
  复旦大学附属肿瘤医院妇瘤科，复旦大学上海医学院肿瘤学系，上海 200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.01.002
  CLC： R737.3
- Received：03 January 2023，
  
  Revised：2023-01-12，
  
  Published：30 January 2023
- 稿件说明：
移动端阅览
Qinhao GUO, Min YU, Xiaohua WU. Progress in diagnosis and treatment of gynecological tumors in 2022[J]. China Oncology, 2023, 33(1): 14-24.
DOI：

Qinhao GUO, Min YU, Xiaohua WU. Progress in diagnosis and treatment of gynecological tumors in 2022[J]. China Oncology, 2023, 33(1): 14-24. DOI： 10.19401/j.cnki.1007-3639.2023.01.002.

摘要

2022年，国家癌症中心发布的最新数据显示，中国妇科肿瘤的发病率呈上升趋势，以卵巢癌为例，年新发病例数为57 200例，粗发病率为8.47/10万，年死亡病例数为27 200例，粗死亡率达4.04/10万，发病率和死亡率均高于世标率（分别为5.59/10万和2.45/10万），中国从事妇科肿瘤防治事业的医师面临更大的挑战。妇科肿瘤在早期经过规范性治疗后整体疗效较好，但对于晚期、复发转移的患者，有限的治疗模式及高复发率往往导致预后较差。近年来，靶向治疗、免疫治疗、抗体药物偶联物治疗等新兴治疗方式开创了妇科肿瘤治疗的新纪元，为妇科肿瘤患者带来了更多治疗希望。本文总结2022年度妇科肿瘤手术治疗、放疗、化疗、靶向治疗、免疫治疗和生物标志物检测等方面的重大进展，以期更好地指导妇科肿瘤个体化精准治疗。

Abstract

In 2022

the National Cancer Center released the latest data. The results show that the incidence of gynecologic tumors in China shows an upward trend. Taking ovarian cancer as an example

the annual number of new cases is 57 200

with a crude incidence rate of 8.47/100 000

and the annual number of death cases is 27 200

with a crude mortality rate of 4.04/100 000

and the morbidity and mortality are higher than the world standard rates (5.59/100 000 and 2.45/100 000

respectively). Physicians practicing gynecologic oncology in China face greater challenges. Patients with early gynecologic tumors have better overall outcomes after standardized treatment. However

limited treatment modalities and high recurrence rates often lead to poorer prognosis for patients with advanced

recurrent or metastatic gynecologic malignancies. In recent years

emerging treatments such as targeted therapy

immunotherapy and antibody-drug conjugate have ushered in a new era in the treatment of gynecologic tumors

bringing more hope to patients. This article summarized the significant advances in gynecological tumor surgery

radiotherapy

chemotherapy

targeted therapy

immunotherapy and biomarkers in the past year

so as to better guide the individualized and precise treatment of gynecologic tumors.

关键词

Keywords

references

RAMIREZ P T , FRUMOVITZ M , PAREJA R , et al . Minimally invasive versus abdominal radical hysterectomy for cervical cancer [J ] . N Engl J Med , 2018 , 379 ( 20 ): 1895 - 1904 . DOI: 10.1056/NEJMoa1806395 http://doi.org/10.1056/NEJMoa1806395 http://www.nejm.org/doi/10.1056/NEJMoa1806395 http://www.nejm.org/doi/10.1056/NEJMoa1806395

RAMIREZ P , FRUMOVITZ M , PAREJA R , et al . Open vs. Minimally Invasive Radical Hysterectomy in Early Cervical Cancer: LACC Trial Final Analysis (LBA 10) [J ] . Gynecol Oncol , 2022 , 166 : S53 - S54 . DOI: 10.1016/S0090-8258(22)01302-6 http://doi.org/10.1016/S0090-8258(22)01302-6 https://linkinghub.elsevier.com/retrieve/pii/S0090825822013026 https://linkinghub.elsevier.com/retrieve/pii/S0090825822013026

National Comprehensive Cancer Network . NCCN Guidelines for treatment of cervical cancer [J ] . (2017-05-15)[ 2022 -12-20 ] . https://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf https://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf https://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf.

CIBULA D , KÖHLER C , BAJSOVÁ S , et al . 526MO Pathological assessment of sentinel lymph node in early-stage cervical cancer: results from the prospective SENTIX trial (CEEGOG-CX01; ENGOT-CX2) [J ] . Ann Oncol , 2022 , 33 : S786 .

CHEN J , LI K , HAN Y , et al . 560P Neoadjuvant camrelizumab plus chemotherapy in patients with locally advanced cervical cancer (NACI): a prospective, single-arm, phase Ⅱ trial [J ] . Ann Oncol , 2022 , 33 : S804 . DOI: 10.1016/j.annonc.2022.07.688 http://doi.org/10.1016/j.annonc.2022.07.688 https://linkinghub.elsevier.com/retrieve/pii/S092375342202539X https://linkinghub.elsevier.com/retrieve/pii/S092375342202539X

MAYADEV J , ZAMARIN D , DENG W , et al . Safety and immunogenicity of Anti PD-L1 (atezolizumab) given as an immune primer or concurrently with extended field chemoradiotherapy for node positive locally advanced cervical cancer: an NRG Oncology trial (024) [J ] . Gynecol Oncol , 2022 , 166 : S18 - S19 .

Rodrigues M , Loap P , Dubot C , et al . 2022. Combination of nivolumab with chemoradiotherapy for locally advanced cervical cancer: NiCOL phase I trial [J ] . American Society of Clinical Oncology .

XIAO Y , CHENG H , WANG L , et al . 562P Camrelizumab plus concurrent chemoradiotherapy for locally advanced cervical cancer: preliminary results of a single-arm, open-label, phase Ⅱ trial [J ] . Ann Oncol , 2022 , 33 : S805 .

MONK B , TOITA T , WU X H , et al . Durvalumab, in combination with and following chemoradiotherapy, in locally advanced cervical cancer: results from the phase 3 international, randomized, double-blind, placebo-controlled CALLA trial [R ] . Oral Abstracts (Regular and Late-Breaking Submission). BMJ Publishing Group Ltd , 2022 .

NASIOUDIS D , RAMIREZ P T . 2022 Society of Gynecologic Oncology meeting report [J ] . Int J Gynecol Cancer , 2022 . [Online ahead of print ]

National Comprehensive Cancer Network . NCCN Clinical Practice Guidelines in Oncology. Cervical Cancer. Version 1. 2022 [EB/OL ] . [ 2022-12-20 ] . https://www.nccn.org/professionals/physician_gls/pdf/cervical https://www.nccn.org/professionals/physician_gls/pdf/cervical https://www.nccn.org/professionals/physician_gls/pdf/cervical.

NODA K , TESHIMA K , IKEDA M , et al . Phase Ⅱ study of UFT in cancer of the uterine cervix [J ] . Gan To Kagaku Ryoho , 1985 , 12 ( 4 ): 900 - 906 .

NODA K , OHASHI Y , SUGIMORI H , et al . Phase Ⅲ double-blind randomized trial of radiation therapy for stage Ⅲb cervical cancer in combination with low- or high-dose Z-100: treatment with immunomodulator, more is not better [J ] . Gynecol Oncol , 2006 , 101 ( 3 ): 455 - 463 . DOI: 10.1016/j.ygyno.2005.11.006 http://doi.org/10.1016/j.ygyno.2005.11.006 https://linkinghub.elsevier.com/retrieve/pii/S0090825805009832 https://linkinghub.elsevier.com/retrieve/pii/S0090825805009832

FUJIWARA K , NISHIO S , YAMAMOTO K , et al . LBA31 Randomized phase Ⅲ trial of maintenance chemotherapy with tegafur-uracil versus observation following concurrent chemoradiotherapy for locally advanced cervical cancer, GOTIC-002 LUFT trial [J ] . Ann Oncol , 2022 , 33 : S1398 .

TEWARI K S , COLOMBO N , MONK B J , et al . Pembrolizumab+chemotherapy in patients with persistent, recurrent, or metastatic cervical cancer: subgroup analysis of KEYNOTE-826 [M ] . American Society of Clinical Oncology , 2022 .

MONK B , TEWARI K , DUBOT C , et al . Patient-reported outcomes from the phase 3 randomized, double-blind, KEYNOTE-826 trial of pembrolizumab plus chemotherapy versus placebo plus chemotherapy for the first-line treatment of persistent, recurrent, or metastatic cervical cancer (023) [J ] . Gynecol Oncol , 2022 , 166 : S18 .

LORUSSO D , VERGOTE I , O’CEARBHAILL R E , et al . Tisotumab vedotin (TV)+ pembrolizumab (pembro) in first-line (1L) recurrent or metastatic cervical cancer (r/mCC): interim results of ENGOT Cx8/GOG 3024/innovaTV 205 [M ] . American Society of Clinical Oncology , 2022 .

OAKNIN A , MOORE K N , MEYER T , et al . 520MO Safety and efficacy of nivolumab (NIVO)±ipilimumab (IPI) in patients (pts) with recurrent/metastatic cervical cancer (R/M Cx Ca) in checkmate 358 [J ] . Ann Oncol , 2022 , 33 : S782 . DOI: 10.1016/j.annonc.2022.07.648 http://doi.org/10.1016/j.annonc.2022.07.648 https://linkinghub.elsevier.com/retrieve/pii/S0923753422024991 https://linkinghub.elsevier.com/retrieve/pii/S0923753422024991

WANG J , LOU H M , CAI H B , et al . A study of AK104 (an anti-PD1 and anti-CTLA4 bispecific antibody) combined with standard therapy for the first-line treatment of persistent, recurrent, or metastatic cervical cancer (R/M CC) [J ] . J Clin Oncol , 2022 , 40 ( 16_suppl ): 106 .

AN J S , WU L Y , LI X M , et al . Efficacy and safety of serplulimab (an anti-PD-1 antibody) combined with albumin-bound paclitaxel in patients with advanced cervical cancer who have progressive disease or intolerable toxicity after first-line standard chemotherapy (074) [J ] . Gynecol Oncol , 2022 , 166 : S47 .

TEWARI K S , MONK B J , VERGOTE I , et al . Survival with cemiplimab in recurrent cervical cancer [J ] . N Engl J Med , 2022 , 386 ( 6 ): 544 - 555 . DOI: 10.1056/NEJMoa2112187 http://doi.org/10.1056/NEJMoa2112187 http://www.nejm.org/doi/10.1056/NEJMoa2112187 http://www.nejm.org/doi/10.1056/NEJMoa2112187

XU Q , WANG J J , SUN Y , et al . Efficacy and safety of sintilimab plus anlotinib for PD-L1-positive recurrent or metastatic cervical cancer: a multicenter, single-arm, prospective phase Ⅱ trial [J ] . J Clin Oncol , 2022 , 40 ( 16 ): 1795 - 1805 .

ZHENG M , Y ZHOU , ZHOU J , et al . 564P Efficacy and safety of tislelizumab plus anlotinib in the treatment of cervical cancer resistant to standard therapy: a prospective, single-arm, open labelled phase Ⅱ clinical trial [J ] . Ann Oncol , 2022 , 33 : S806 .

OAKNIN A , BACKES F , VAN NIEUWENHUYSEN E , et al . LIO-1: initial phase 2 experience of lucitanib+nivolumab in patients with metastatic or recurrent cervical cancer (NCT04042116; ENGOT-GYN3/AGO/LIO) (034) [J ] . Gynecol Oncol , 2022 , 166 : S24 .

XIA L F , ZHOU Q , GAO Y N , et al . A multicenter phase 2 trial of camrelizumab plus famitinib for women with recurrent or metastatic cervical squamous cell carcinoma [J ] . Nat Commun , 2022 , 13 ( 1 ): 7581 . DOI: 10.1038/s41467-022-35133-4 http://doi.org/10.1038/s41467-022-35133-4

O’MALLEY D M , NEFFA M , MONK B J , et al . Dual PD-1 and CTLA-4 checkpoint blockade using balstilimab and zalifrelimab combination as second-line treatment for advanced cervical cancer: an open-label phaseⅡ study [J ] . J Clin Oncol , 2022 , 40 ( 7 ): 762 - 771 . DOI: 10.1200/JCO.21.02067 http://doi.org/10.1200/JCO.21.02067 https://ascopubs.org/doi/10.1200/JCO.21.02067 https://ascopubs.org/doi/10.1200/JCO.21.02067

WU X H , JI J F , LOU H M , et al . Efficacy and safety of cadonilimab, an anti-PD-1/CTLA4 bi-specific antibody, in previously treated recurrent or metastatic (R/M) cervical cancer: a multicenter, open-label, single-arm, phase Ⅱ trial (075) [J ] . Gynecol Oncol , 2022 , 166 : S47 - S48 .

SIVARS L , HELLMAN K , CRONA GUTERSTAM Y , et al . Circulating cell-free tumor human papillomavirus DNA is a promising biomarker in cervical cancer [J ] . Gynecol Oncol , 2022 , 167 ( 1 ): 107 - 114 . DOI: 10.1016/j.ygyno.2022.07.028 http://doi.org/10.1016/j.ygyno.2022.07.028

NORPPA N , STAFF S , HELMINEN M , et al . Improved survival after implementation of ultra-radical surgery in advanced epithelial ovarian cancer: results from a tertiary referral center [J ] . Gynecol Oncol , 2022 , 165 ( 3 ): 478 - 485 . DOI: 10.1016/j.ygyno.2022.03.023 http://doi.org/10.1016/j.ygyno.2022.03.023

TANYI J L , RANDALL L M , CHAMBERS S K , et al . A phase Ⅲ study of pafolacianine injection (OTL38) for intraoperative imaging of folate receptor-positive ovarian cancer (study 006) [J ] . J Clin Oncol , 2023 , 41 ( 2 ): 276 - 284 . DOI: 10.1200/JCO.22.00291 http://doi.org/10.1200/JCO.22.00291 https://ascopubs.org/doi/10.1200/JCO.22.00291 https://ascopubs.org/doi/10.1200/JCO.22.00291

SEHOULI J , FOTOPOULOU C , VERGOTE I , et al . Role of cytoreductive surgery for the second ovarian cancer relapse in patients previously treated with chemotherapy alone at first relapse: a subanalysis of the DESKTOP Ⅲ trial [J ] . J Clin Oncol , 2022 , 40 ( 16_suppl ): 5520 . DOI: 10.1200/JCO.2022.40.16_suppl.5520 http://doi.org/10.1200/JCO.2022.40.16_suppl.5520 https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.5520 https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.5520

LECURU F , SEHOULI J , VERGOTE I B , et al . 573P Role of CA125 in patients included in the DESKTOP Ⅲ/ENGOT-ov20 trial [J ] . Ann Oncol , 2022 , 33 : S809 .

ZHOU D C , LIU J H , LIU R H , et al . Effectiveness and safety of niraparib as neoadjuvant therapy in advanced ovarian cancer with homologous recombination deficiency (NANT): study protocol for a prospective, multicenter, exploratory, phase 2, single-arm study [J ] . Front Oncol , 2022 , 12 : 852772 . DOI: 10.3389/fonc.2022.852772 http://doi.org/10.3389/fonc.2022.852772 https://www.frontiersin.org/articles/10.3389/fonc.2022.852772/full https://www.frontiersin.org/articles/10.3389/fonc.2022.852772/full

LIM M C , CHANG S J , PARK B , et al . Survival after hyperthermic intraperitoneal chemotherapy and primary or interval cytoreductive surgery in ovarian cancer: a randomized clinical trial [J ] . JAMA Surg , 2022 , 157 ( 5 ): 374 - 383 . DOI: 10.1001/jamasurg.2022.0143 http://doi.org/10.1001/jamasurg.2022.0143 https://jamanetwork.com/journals/jamasurgery/fullarticle/2789724 https://jamanetwork.com/journals/jamasurgery/fullarticle/2789724

FILIS P , MAURI D , MARKOZANNES G , et al . Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer: a systematic review and meta-analysis of randomized trials [J ] . ESMO Open , 2022 , 7 ( 5 ): 100586 . DOI: 10.1016/j.esmoop.2022.100586 http://doi.org/10.1016/j.esmoop.2022.100586 https://linkinghub.elsevier.com/retrieve/pii/S2059702922002162 https://linkinghub.elsevier.com/retrieve/pii/S2059702922002162

FUJIWARA K , KRISTELEIT R , GHAMANDE S , et al . 178O Rucaparib maintenance treatment in patients (pts) with newly diagnosed ovarian cancer (OC): defining benefit according to disease risk subgroups within the phase Ⅲ ATHENA-MONO study [J ] . Ann Oncol , 2022 , 33 : S1505 - S1506 . DO I: 10.1016/j.annonc.2022.10.214 http://doi.org/10.1016/j.annonc.2022.10.214 https://linkinghub.elsevier.com/retrieve/pii/S0923753422044052 https://linkinghub.elsevier.com/retrieve/pii/S0923753422044052

DISILVESTRO P , BANERJEE S , COLOMBO N , et al . 517O Overall survival (OS) at 7-year (y) follow-up (f/u) in patients (pts) with newly diagnosed advanced ovarian cancer (OC) and a BRCA mutation (BRCAm) who received maintenance olaparib in the SOLO1/GOG-3004 trial [J ] . Ann Oncol , 2022 , 33 : S779 . DOI: 10.1016/j.annonc.2022.07.645 http://doi.org/10.1016/j.annonc.2022.07.645 https://linkinghub.elsevier.com/retrieve/pii/S0923753422024966 https://linkinghub.elsevier.com/retrieve/pii/S0923753422024966

RAY-COQUARD I L , LEARY A , PIGNATA S , et al . LBA29 Final overall survival (OS) results from the phase Ⅲ PAOLA-1/ENGOT-ov25 trial evaluating maintenance olaparib (ola) plus bevacizumab (bev) in patients (pts) with newly diagnosed advanced ovarian cancer (AOC) [J ] . Ann Oncol , 2022 , 33 : S1396 - S1397 .

GAO Q L , ZHU J Q , ZHAO W D , et al . Olaparib maintenance monotherapy in Asian patients with platinum-sensitive relapsed ovarian cancer: phase Ⅲ trial (L-MOCA) [J ] . Clin Cancer Res , 2022 , 28 ( 11 ): 2278 - 2285 . DOI: 10.1158/1078-0432.CCR-21-3023 http://doi.org/10.1158/1078-0432.CCR-21-3023 https://aacrjournals.org/clincancerres/article/28/11/2278/698916/Olaparib-Maintenance-Monotherapy-in-Asian-Patients https://aacrjournals.org/clincancerres/article/28/11/2278/698916/Olaparib-Maintenance-Monotherapy-in-Asian-Patients

GSK . GSK provides an update on Zejula (niraparib) US prescribing information [EB/OL ] . ( 2022-11-11 )[ 2022-12-20 ] . https://www.gsk.com/en-gb/media/press-releases/gsk-provides-an-update-on-zejula-niraparib-us-prescribing-information/ https://www.gsk.com/en-gb/media/press-releases/gsk-provides-an-update-on-zejula-niraparib-us-prescribing-information/ https://www.gsk.com/en-gb/media/press-releases/gsk-provides-an-update-on-zejula-niraparib-us-prescribing-information/.

MIRZA M , WU X , ZHU J , et al . VP7-2022: an ad-hoc interim overall survival results of niraparib with individualized starting dose as maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer (NORA): a double-blind, randomized, placebo-controlled, phase Ⅲ trial [J ] . Ann Oncol , 2022 . [Online ahead of print ]

KRISTELEIT R , OZA A M . Rucaparib for recurrent ovarian cancer with BRCA 1 and BRCA 2 mutations-authors’ reply [J ] . Lancet Oncol , 2022 , 23 ( 7 ): e315 . DOI: 10.1016/S1470-2045(22)00343-6 http://doi.org/10.1016/S1470-2045(22)00343-6 https://linkinghub.elsevier.com/retrieve/pii/S1470204522003436 https://linkinghub.elsevier.com/retrieve/pii/S1470204522003436

MATULONIS U , LORUSSO D , OAKNIN A , et al . Efficacy and safety of mirvetuximab soravtansine in patients with platinum-resistant ovarian cancer with high folate receptor alpha expression: results from the SORAYA study (LBA 4) [J ] . Gynecol Oncol , 2022 , 166 : S50 .

COLOMBO N , VAN GORP T , MATULONIS U A , et al . Overall survival data from a 3-arm, randomized, open-label, phase 2 study of relacorilant, a selective glucocorticoid receptor modulator, combined with nab-paclitaxel in patients with recurrent platinum-resistant ovarian cancer [J ] . J Clin Oncol , 2022 , 40 ( 17_suppl ): LBA5503 . DOI: 10.1200/JCO.2022.40.17_suppl.LBA5503 http://doi.org/10.1200/JCO.2022.40.17_suppl.LBA5503 https://ascopubs.org/doi/10.1200/JCO.2022.40.17_suppl.LBA5503 https://ascopubs.org/doi/10.1200/JCO.2022.40.17_suppl.LBA5503

O’MALLEY D , BARIANI G M , CASSIER P A , et al . 546P Pembrolizumab for microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) advanced endometrial cancer: long-term follow-up results from KEYNOTE-158 [J ] . Ann Oncol , 2022 , 33 : S796 - S797 .

TINKER A V , POTHURI B , GILBERT L , et al . 548P Progression-free survival (PFS) and overall survival (OS) in advanced/recurrent (AR) mismatch repair deficient/microsatellite instability-high or proficient/stable (dMMR/MSI-H or MMRp/MSS) endometrial cancer (EC) treated with dostarlimab in the GARNET study [J ] . Ann Oncol , 2022 , 33 : S798 - S799 . DOI: 10.1016/j.annonc.2022.07.676 http://doi.org/10.1016/j.annonc.2022.07.676 https://linkinghub.elsevier.com/retrieve/pii/S0923753422025273 https://linkinghub.elsevier.com/retrieve/pii/S0923753422025273

MAKKER V , COLOMBO N , CASADO HERRAEZ A , et al . 525MO Updated efficacy and safety of lenvatinib (LEN) + pembrolizumab (pembro) vs treatment of physician’s choice (TPC) in patients (pts) with advanced endometrial cancer (aEC): study 309/KEYNOTE-775 [J ] . Ann Oncol , 2022 , 33 : S785 - S786 . DOI: 10.1016/j.annonc.2022.07.653 http://doi.org/10.1016/j.annonc.2022.07.653 https://linkinghub.elsevier.com/retrieve/pii/S0923753422025042 https://linkinghub.elsevier.com/retrieve/pii/S0923753422025042

WU X , LIANG S , CHEN X , et al . 555P TQB2450 injection combined with anlotinib hydrochloride capsule in the treatment of advanced, recurrent or metastatic endometrial cancer: a multicohort, open label, multicenter phase Ⅱ clinical trial - The TQB2450-Ⅱ-08 trial [J ] . Ann Oncol , 2022 , 33 : S802 .

BRADLEY W H , HAYES M P , TAYLOR N , et al . An open label, nonrandomized, multisite phase Ⅱ trial combining bevacizumab, atezolizumab, and rucaparib for the treatment of previously treated recurrent and progressive endometrial cancer [M ] . American Society of Clinical Oncology , 2022 .

TAN D S , KIM Y M , LIM M C , et al . 101P Real-world prevalence of MSI-H/dMMR across 6 different tumor types in Asia [J ] . Ann Oncol , 2022 , 33 : S585 .

ZHANG Q , MA X , CAO W , et al . 558P Molecular subtyping endometrial carcinoma in Chinese population applying an NGS-based classifier and its association with prognosis [J ] . Ann Oncol , 2022 , 33 : S803 .

SIEGENTHALER F , TEIEN LANDE K , KRAKSTAD C , et al . 589P Circulating tumour DNA as prognostic factor in endometrial cancer: updated results from an international multicenter study [J ] . Ann Oncol , 2022 , 33 : S816 .

SHAPIRA-FROMMER R , MILESHKIN L , MANZYUK L , et al . Efficacy and safety of pembrolizumab for patients with previously treated advanced vulvar squamous cell carcinoma: results from the phase 2 KEYNOTE-158 study [J ] . Gynecol Oncol , 2022 , 166 ( 2 ): 211 - 218 . DOI: 10.1016/j.ygyno.2022.01.029 http://doi.org/10.1016/j.ygyno.2022.01.029 https://linkinghub.elsevier.com/retrieve/pii/S0090825822000671 https://linkinghub.elsevier.com/retrieve/pii/S0090825822000671

Views

4634

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Progress in treatment of gynecological cancer in 2023

The latest progress and prospect of gynecological tumor treatment at 2023 ESMO

Annual Progress Review of Gynecologic Malignancies in 2025

Progress in diagnosis and treatment of mucinous ovarian cancer

Progress in menopausal hormone therapy for postoperative patients with gynecological malignant cancer

Related Author

Zheng FENG

Jun ZHU

Hao WEN

Lingfang XIA

Tong LI

Huijuan YANG

Mingming ZHAO

Tianyou WANG

Related Institution

Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, State Key Laboratory of Genetic Engineering, Fudan University, Institute of Thoracic Oncology, Fudan University, Department of Oncology, Shanghai Medical College, Fudan University

Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University

复旦大学附属肿瘤医院妇瘤科，复旦大学上海医学院肿瘤学系

Department of Obstetrics and Gynecology, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University)

AI问答

⁰