Analysis of risk factors of recurrence in non-muscle invasive bladder cancer patients after initial transurethral resection of bladder tumor

Duocai TANG; Shukui ZHOU; Guiyin ZHANG; Lei LIU; Hong LIAO

doi:10.19401/j.cnki.1007-3639.2023.05.008

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Analysis of risk factors of recurrence in non-muscle invasive bladder cancer patients after initial transurethral resection of bladder tumor

Article | 更新时间：2025-12-31

- Analysis of risk factors of recurrence in non-muscle invasive bladder cancer patients after initial transurethral resection of bladder tumor
- China Oncology Vol. 33, Issue 5, Pages: 478-483(2023)
- 作者机构：
  
  1. 成都医学院，四川成都 610500
  2. 电子科技大学附属肿瘤医院（四川省肿瘤医院 · 研究所）泌尿外科，四川成都 610041
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.05.008
  CLC： R737.14
- Received：26 August 2022，
  
  Revised：2022-11-17，
  
  Published：30 May 2023
- 稿件说明：
移动端阅览
Duocai TANG, Shukui ZHOU, Guiyin ZHANG, et al. Analysis of risk factors of recurrence in non-muscle invasive bladder cancer patients after initial transurethral resection of bladder tumor[J]. China Oncology, 2023, 33(5): 478-483.
DOI：

Duocai TANG, Shukui ZHOU, Guiyin ZHANG, et al. Analysis of risk factors of recurrence in non-muscle invasive bladder cancer patients after initial transurethral resection of bladder tumor[J]. China Oncology, 2023, 33(5): 478-483. DOI： 10.19401/j.cnki.1007-3639.2023.05.008.

摘要

背景与目的：

非肌层浸润性膀胱癌（non-muscle invasive bladder cancer，NMIBC）患者行经尿道膀胱肿瘤电切术（transurethral resection of bladder cancer，TURBT）的术后复发率较高，分析NMIBC患者行初次TURBT术后复发危险因素的相关研究较少。本研究旨在分析NMIBC患者行初次TURBT的术后复发危险因素，有助于筛选复发高危人群，预防性采取相应的干预措施。

方法：

选取2015年12月—2020年5月在电子科技大学附属肿瘤医院行初次TURBT治疗的NMIBC患者197例，随访24~77个月，根据是否复发分为复发组（48例）和非复发组（149例）。对两组临床资料进行单因素分析，将单因素分析差异有统计学意义的指标纳入多因素logistic回归分析，筛选TURBT术后复发的可能危险因素。

结果：

单因素分析显示，未复发组初治时有肉眼血尿、二次电切、肿瘤T分期为T

期、肿瘤分级为高级别、肿瘤多发及未行即刻膀胱内灌注化疗的占比低于复发组，差异有统计学意义（

0.05）。两组的性别、年龄、肿瘤家族史、吸烟史、肿瘤大小及后续膀胱内灌注化疗对比差异无统计学意义（

0.05）。两组中性粒细胞/淋巴细胞、中性粒细胞×血红蛋白/淋巴细胞的受试者工作特征（receiver operating characteristic，ROC）曲线显示差异无统计学意义（

0.05）。多因素logistic回归分析显示，肿瘤T分期为T

期、肿瘤分级为高级别、肿瘤多发及未行即刻膀胱内灌注化疗为NMIBC患者初次TURBT术后复发的独立危险因素（

0.05，OR

1）。

结论：

NMIBC患者行初次TURBT术后复发与肿瘤分期、肿瘤分级、肿瘤数目、是否行即刻膀胱内灌注化疗密切相关，临床上可以采取对应的干预措施，降低患者术后的复发率。

Abstract

Background and purpose:

The recurrence rate of non-muscle invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor (TURBT) is high. There are few studies on the risk factors of recurrence in NMIBC patients after initial TURBT. Our study aimed to screen the high-risk population and take corresponding preventive intervention measures by analyzing the risk factors of recurrence in NMIBC patients after initial TURBT.

Methods:

A total of 197 NMIBC patients who received initial TURBT in The Cancer Hospital of the University of Electronic Science and Technology of China from December 2015 to May 2020 were selected and followed up for 24 to 77 months. Patients were divided into recurrence group (48 cases) and non-recurrence group (149 cases) according to the results. Univariate analysis was performed on the cl

inical data of the two groups

and the indicators with statistical significance were included in the multivariate logistic regression analysis to screen the possible risk factors of recurrence.

Results:

Univariate analysis showed that the difference was statistically significant between two groups in gross hematuria

secondary resection

T1 stage

high grade tumor

multiple tumor and lack of immediate intravesical therapy (

0.05).There was no significant difference in gender

age

family history of tumor

smoking history

tumor size and subsequent intravesical therapy between two groups (

0.05). The receiver operating characteristic (ROC) curves of the ratio of neutrophils to lymphocytes and the ratio of neutrophils and hemoglobin to lymphocytes showed no statistically significant difference between two groups (

0.05). Multivariate logistic regression analysis showed that T1 stage

high grade tumor

multiple tumor and lack of immediate intravesical therapy were independent risk factors of recurrence in NMIBC patients after initial TURBT (

0.05

1).

Conclusion:

The recurrence of NMIBC patients after initial TURBT is closely related to tumor stage

tumor grade

tumor number and immediate intravesical therapy. Corresponding intervention measures can be taken to reduce the postoperative recurrence rate in initial NMIBC patients.

关键词

Keywords

references

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