Clinical study on high-risk factors for contralateral lymph node metastasis in unilateral papillary thyroid carcinoma

Xinyue YUAN; Yao YAO; Shuai CHENG; Xin ZHENG; Yuan ZHANG

doi:10.19401/j.cnki.1007-3639.2023.06.010

您当前的位置：

首页 >

文章列表页 >

Clinical study on high-risk factors for contralateral lymph node metastasis in unilateral papillary thyroid carcinoma

Article | 更新时间：2025-12-31

- Clinical study on high-risk factors for contralateral lymph node metastasis in unilateral papillary thyroid carcinoma
- China Oncology Vol. 33, Issue 6, Pages: 619-628(2023)
- 作者机构：
  
  南京医科大学附属肿瘤医院，江苏省肿瘤医院，江苏省肿瘤防治研究所头颈外科，江苏南京 210000
- 作者简介：
  
  ZHANG Yuan.
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.06.010
  CLC： R736.1
- Received：13 December 2022，
  
  Revised：2023-05-16，
  
  Published：30 June 2023
- 稿件说明：
移动端阅览
Xinyue YUAN, Yao YAO, Shuai CHENG, et al. Clinical study on high-risk factors for contralateral lymph node metastasis in unilateral papillary thyroid carcinoma[J]. China Oncology, 2023, 33(6): 619-628.
DOI：

Xinyue YUAN, Yao YAO, Shuai CHENG, et al. Clinical study on high-risk factors for contralateral lymph node metastasis in unilateral papillary thyroid carcinoma[J]. China Oncology, 2023, 33(6): 619-628. DOI： 10.19401/j.cnki.1007-3639.2023.06.010.

摘要

背景与目的：

甲状腺乳头状癌（papillary thyroid carcinoma，PTC）发生淋巴结转移时会对患者预后产生不良影响，本研究旨在讨论单侧PTC发生对侧中央区淋巴结转移（central lymph node metastases，CLNM）及影像学怀疑同侧颈侧区淋巴结转移（later

al lymph node metastases，LLNM）时发生对侧LLNM的相关高危因素。

方法：

回顾性分析2011年1月—2021年12月于江苏省肿瘤医院头颈外科同一治疗组行手术治疗的526例初治的行甲状腺全切及双侧中央区±颈侧区淋巴结清扫，术后病理学检查确诊为单侧PTC的患者的临床资料，分析发生对侧淋巴结转移的相关高危因素。

结果：

526例患者中，295例为CLNM，其中272例存在同侧CLNM（含同侧和双侧），129例存在对侧CLNM（含对侧和双侧）；165例存在LLNM，其中同侧129例，对侧和双侧转移均为18例。行预防性中央区淋巴结清扫（central lymph node dissection，CLND）的365例中65例（17.8%）出现对侧CLNM；治疗性CLND的161例中68例（42.2%）出现对侧CLNM。单因素及多因素回归分析结果显示，年龄

55岁、肿瘤最大径≥2 cm、CLNM数量≥6枚、多灶、无桥本甲状腺炎及肿瘤外侵与对侧CLNM有关（

均

0.05）；肿瘤最大径≥2 cm与对侧LLNM有关（

0.05），而淋巴结外侵及癌灶侧淋巴结转移是发生对侧CLNM与对侧LLNM的独立危险因素（

均

0.05）。随访显示5年总生存（overall survival，OS）率为97.9%，无病生存（disease-free survival，DFS）率为97.5%。

结论：

单侧PTC患者存在多灶、无桥本甲状腺炎、肿瘤及淋巴结外侵、癌灶侧CLNM、年龄

55岁、肿瘤最大径≥2 cm、CLNM数量≥6枚等高危因素时更易出现对侧CLNM，临床上对出现上述高危因素的患者，应考虑行双侧CLND以降低肿瘤的残留复发。

Abstract

Background and purpose:

The occurrence of lymph node metastasis in papillary thyroid cancer (PTC) can have adverse effects on the prognosis of patients. This study aimed to investigate risk factors related to the occurrence of contralateral central lymph node metastases (CLNM) and contralateral lateral lymph node metastases (LLNM) when imaging suspected ipsilateral LLNM in unilateral PTC.

Methods:

We retrospectively analyzed the clinical data of 526 patients who received surgical treatment in the same treatment group of Jiangsu Cancer Hospital Head and Neck Surgery Department from January 2011 to December 2021. They were initially treated with total thyroidectomy and bilateral central lymph node dissection (CLND) ± lateral lymph node dissection

and their postoperative pathology was uni-PTC. This study analyzed the relevant high-risk factors of contralateral lymph node metastasis.

Results:

Among the 526 patients

295 had CLNM

including 272 ipsilateral CLNM

129 contralateral CLNM and 106 of both sides CLNM; 165 patients had LLNM including 129 ipsilateral LLNM

18 contralateral

LLNM

and 18 of both ipsilateral and contralateral LLNM. Contralateral CLNM occurred in 65 (17.8%) of 365 patients who underwent preventive CLND

and contralateral CLNM was found in 68 (42.2%) of 161 patients with therapeutic CLND. Univariate and multivariate regression analyses showed that contralateral CLNM was associated with maximum diameter of tumor ≥2 cm

multiple foci

no Hashimoto's thyroiditis

tumor invasion

number of CLNM≥6 and age

55 years (

0.05). Maximum diameter of tumor ≥2 cm was related to contralateral LLNM (

0.05)

while lymph extracapsular extension and lymph node metastasis at tumor side were independent risk factors for contralateral CLNM and contralateral LLNM (

0.05). Follow-up showed that 5-year overall survival (OS) rate was 97.9% and 5-year disease-free survival (DFS) rate was 97.5%.

Conclusion:

Contralateral CLNM is more likely to occur in patients with maximum diameter of tumor ≥2 cm

multiple foci

no Hashimoto's thyroiditis

number of CLNM ≥6

age

55 years

tumor and lymph extracapsular extension and lymph node metastasis at the cancer side. In clinical practice

bilateral CLND should be considered for patients with high-risk factors to reduce the residual recurrence of the tumor. Since metastatic rate of contralateral LLNM is relatively low

preventive contralateral lateral lymph node dissection should not be performed routinely when there are no high-risk factors mentioned above.

关键词

Keywords

references

SUNG H , FERLAY J , SIEGEL R L , et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J ] . CA Cancer J Clin , 2021 , 71 ( 3 ): 209 - 249 . DOI: 10.3322/caac.v71.3 http://doi.org/10.3322/caac.v71.3 https://onlinelibrary.wiley.com/toc/15424863/71/3 https://onlinelibrary.wiley.com/toc/15424863/71/3

CAO W , CHEN H D , YU Y W , et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020 [J ] . Chin Med J (Engl) , 2021 , 134 ( 7 ): 783 - 791 .

HIGASHINO M , AYANI Y , TERADA T , et al. Clinical features of poorly differentiated thyroid papillary carcinoma [J ] . Auris Nasus Larynx , 2019 , 46 ( 3 ): 437 - 442 . DOI: S0385-8146(18)30526-1 http://doi.org/S0385-8146(18)30526-1

中国临床肿瘤学会指南工作委员会 . 中国临床肿瘤学会(CSCO)分化型甲状腺癌诊疗指南2021 [J ] . 肿瘤预防与治疗 , 2021 , 34 ( 12 ): 1164 - 1201 .

Guidelines Working Committee of the Chinese Clinical Oncology Society . Chinese society of clinical oncology (CSCO) guidelines for diagnosis and treatment of differentiated thyroid cancer 2021 [J ] . J Cancer Control Treat , 2021 , 34 ( 12 ): 1164 - 1201 .

ZHOU L , LI Q Q , CHEN S C , et al. Synergic effects of histology subtype, lymph node metastasis, and distant metastasis on prognosis in differentiated thyroid carcinoma using the SEER database [J ] . Gland Surg , 2020 , 9 ( 4 ): 907 - 918 . DOI: 10.21037/gs-20-273 http://doi.org/10.21037/gs-20-273

KIM D H , KIM G J , KIM S W , et al. Predictive value of ipsilateral central lymph node metastasis for contralateral central lymph node metastasis in patients with thyroid cancer: systematic review and meta-analysis [J ] . Head Neck , 2021 , 43 ( 10 ): 3177 - 3184 . DOI: 10.1002/hed.v43.10 http://doi.org/10.1002/hed.v43.10 https://onlinelibrary.wiley.com/toc/10970347/43/10 https://onlinelibrary.wiley.com/toc/10970347/43/10

AMIN M B , GREENE F L , EDGE S B , et al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging [J ] . CA Cancer J Clin , 2017 , 67 ( 2 ): 93 - 99 . DOI: 10.3322/caac.21388 http://doi.org/10.3322/caac.21388 http://doi.wiley.com/10.3322/caac.21388 http://doi.wiley.com/10.3322/caac.21388

HAUGEN B R , ALEXANDER E K , BIBLE K C , et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer [J ] . Thyroid , 2016, 26 ( 1 ): 1 - 133 . DOI: 10.1089/thy.2015.0020 http://doi.org/10.1089/thy.2015.0020 https://www.liebertpub.com/doi/10.1089/thy.2015.0020 https://www.liebertpub.com/doi/10.1089/thy.2015.0020

中国医疗保健国际交流促进会营养与代谢管理分会中国营养学会临床营养分会中华医学会糖尿病学分会 , 等 . 中国超重/肥胖医学营养治疗指南(2021) [J ] . 中国医学前沿杂志(电子版) , 2021 , 13 ( 11 ): 1 - 55 .

Nutrition and Metabolism Management Branch of China Health Care International Exchange Promotion Association Clinical Nutrition Branch of China Nutrition Society Diabetes Branch of Chinese Medical Association, et al. Guidelines for medical nutrition treatment of overweight/obesity in China (2021) [J ] Chin J Med Frontiers (Electronic Edition) , 2021 , 13 ( 11 ): 1 - 55 .

MIN Y , HUANG Y Z , WEI M J , et al. Preoperatively predicting the central lymph node metastasis for papillary thyroid cancer patients with Hashimoto’s thyroiditis [J ] . Front Endocrinol (Lausanne) , 2021 , 12 : 713475 . DOI: 10.3389/fendo.2021.713475 http://doi.org/10.3389/fendo.2021.713475 https://www.frontiersin.org/articles/10.3389/fendo.2021.713475/full https://www.frontiersin.org/articles/10.3389/fendo.2021.713475/full

MEDAS F , CANU G L , CAPPELLACCI F , et al. Prophylactic central lymph node dissection improves disease-free survival in patients with intermediate and high risk differentiated thyroid carcinoma: a retrospective analysis on 399 patients [J ] . Cancers (Basel) , 2020 , 12 ( 6 ): 1658 . DOI: 10.3390/cancers12061658 http://doi.org/10.3390/cancers12061658 https://www.mdpi.com/2072-6694/12/6/1658 https://www.mdpi.com/2072-6694/12/6/1658

GRŠIĆ K , BUMBER B , CURIĆ RADIVOJEVIĆ R , et al. Prophylactic central neck dissection in well-differentiated thyroid cancer [J ] . Acta Clin Croat , 2020 , 59 ( Suppl 1 ): 87 - 95 . DOI: 10.20471/acc.2020.59.s1.11 http://doi.org/10.20471/acc.2020.59.s1.11

CABANILLAS M E , MCFADDEN D G , DURANTE C . Thyroid cancer [J ] . Lancet , 2016 , 388 ( 10061 ): 2783 - 2795 . DOI: S0140-6736(16)30172-6 http://doi.org/S0140-6736(16)30172-6

TAN H L , HUANG B Q , LI G Y , et al. A prediction model for contralateral central neck lymph node metastases in unilateral papillary thyroid cancer [J ] . Int J Endocrinol , 2021 , 2021 : 6621067 .

ROBINSON T J , THOMAS S , DINAN M A , et al. How many lymph nodes are enough? Assessing the adequacy of lymph node yield for papillary thyroid cancer [J ] . J Clin Oncol , 2016 , 34 ( 28 ): 3434 - 3439 . DOI: 10.1200/JCO.2016.67.6437 http://doi.org/10.1200/JCO.2016.67.6437

YANG Z Y , HENG Y , ZHAO Q W , et al. A specific predicting model for screening skip metastasis from patients with negative central lymph nodes metastasis in papillary thyroid cancer [J ] . Front Endocrinol (Lausanne) , 2021 , 12 : 743900 . DOI: 10.3389/fendo.2021.743900 http://doi.org/10.3389/fendo.2021.743900 https://www.frontiersin.org/articles/10.3389/fendo.2021.743900/full https://www.frontiersin.org/articles/10.3389/fendo.2021.743900/full

SHI R L , QU N , YANG S W , et al. Tumor size interpretation for predicting cervical lymph node metastasis using a differentiated thyroid cancer risk model [J ] . Onco Targets Ther , 2016 , 9 : 5015 - 5022 . DOI: 10.2147/OTT http://doi.org/10.2147/OTT https://www.dovepress.com/oncotargets-and-therapy-journal https://www.dovepress.com/oncotargets-and-therapy-journal

CUI N , SUN Q , CHEN L . A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma [J ] . Medicine (Baltimore) , 2021 , 100 ( 32 ): e26882 . DOI: 10.1097/MD.0000000000026882 http://doi.org/10.1097/MD.0000000000026882 https://journals.lww.com/10.1097/MD.0000000000026882 https://journals.lww.com/10.1097/MD.0000000000026882

TAM A A , ÖZDEMIR D , FAKI S , et al. ABO blood groups, Rh factor, and thyroid cancer risk: to ‘B’ or not to ‘B’ [J ] . Endocr Res , 2020 , 45 ( 2 ): 137 - 146 . DOI: 10.1080/07435800.2019.1695261 http://doi.org/10.1080/07435800.2019.1695261 https://www.tandfonline.com/doi/full/10.1080/07435800.2019.1695261 https://www.tandfonline.com/doi/full/10.1080/07435800.2019.1695261

Views

1332

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The importance of clinical practice in papillary thyroid cancer with lymph node metastasis between sternocleidomastoid and sternohyoid muscles

Effects ofBRAFV600E mutation on oncogenesis and prognosis in papillary thyroid cancer

The value of carbon nano-particles-labeled lymph nodes in neck dissection for papillary thyroid cancer

Research on the correlation between BMI and pathologic factors of papillary thyroid carcinoma

The effect of empiric¹³¹I therapy in papillary thyroid cancer patients with pulmonary metastasis

Related Author

嵇庆海

孙国华

王　宇

张婷婷

渠　宁

史荣亮

蔡辉华

安　勇

Related Institution

复旦大学附属肿瘤医院头颈外科，复旦大学上海医学院肿瘤学系

常州市第一人民医院普通外科，苏州大学附属第三医院

皖南医学院第二附属医院普外科

皖南医学院弋矶山医院甲乳外科

皖南医学院第二附属医院基础实验室

AI问答

⁰