The specification and use of <sup>18</sup>F-FES PET in breast cancer

Zhongyi YANG; Xiaoping XU; Mingwei WANG; Yongping ZHANG; Jianwei YANG; Yue CHEN; Wengui XU; Yaming LI; Yingjian ZHANG; Shaoli SONG

doi:10.19401/j.cnki.1007-3639.2023.08.009

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The specification and use of ¹⁸F-FES PET in breast cancer

Guideline and concensus | 更新时间：2025-12-31

- The specification and use of ¹⁸F-FES PET in breast cancer
- China Oncology Vol. 33, Issue 8, Pages: 801-808(2023)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系，复旦大学生物医学影像研究中心，上海分子影像探针工程技术研究中心，上海 200032
  2. 河南省肿瘤医院PET中心，河南郑州 450008
  3. 西南医科大学附属医院核医学科，四川泸州 646000
  4. 天津医科大学肿瘤医院分子影像及核医学诊疗科，天津 300060
  5. 中国医科大学附属第一医院核医学科，辽宁沈阳 110001
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.08.009
  CLC： R737.9
- Received：03 May 2023，
  
  Revised：2023-06-25，
  
  Published：30 August 2023
- 稿件说明：
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Zhongyi YANG, Xiaoping XU, Mingwei WANG, et al. The specification and use of ¹⁸F-FES PET in breast cancer[J]. China Oncology, 2023, 33(8): 801-808.
DOI：

Zhongyi YANG, Xiaoping XU, Mingwei WANG, et al. The specification and use of ¹⁸F-FES PET in breast cancer[J]. China Oncology, 2023, 33(8): 801-808. DOI： 10.19401/j.cnki.1007-3639.2023.08.009.

摘要

约2/3的乳腺癌患者病灶为雌激素受体（estrogen receptor，ER）阳性。在活体内无创检测ER，并对其生物活性进行动态监测对作出个体化治疗决策至关重要。国内已有系列临床前和临床研究提示16α-

F-17β-氟雌二醇（16α-

F-17β-fluoroestradiol，

F-FES）正电子发射体层成像（positron emission tomography，PET）可用于ER表达分析，但尚缺乏相应技术规范。本技术标准由国内开展

F-FES PET研究与应用的专家共同执笔，参考自身经验及国内外该领域研究进展后共同商议制定。本技术标准介绍了

F-FES的合成方法和质量控制要求，给出其临床应用场景的推荐，并进行分级。此外，从显像前准备、显像流程、图像分析（正常生物分布、ER阳性和阴性的判定、病灶部位、影响因素、假阴性和假阳性、报告书写）等全流程系统、详尽给出了专家建议，指出了该显像技术的局限性，并对未来应用前景予以展望。该技术标准的制定旨在推动

F-FES PET技术在国内的规范化应用，实现报告解读一致、结果互认、指标可比，为乳腺癌精准诊疗提供重要的分子影像技术支撑。

Abstract

Estrogen receptor (ER) is overexpressed in approximately 2/3 of breast cancer patients’ lesions. Noninvasive detection of ER

in vivo

and dynamic monitoring of ER are crucial for individualized treatment decision-making. 16α-

F-17β-fluoroestradiol (

F-FES) positron emission tomography (PET) has been used in a variety of preclinical and clinical studies to detect ER expression. However

there is still a lack of technical specifications in China. This technical specification was jointly written by domestic experts who had experience of

F-FES PET imaging and was formed through consultation based on their own experience and research progress in this field both domestically and internationally. This technical specification introduced the synthesis method and quality control requirements of

F-FES

recommended its clinical application scenarios

and classified them. In addition

experts’ suggestions were provided throughout the entire process systemically and detailly

including

pre-imaging preparation

imaging process

image analysis (normal biological distribution

determination of ER positive and negative

lesion detection

influencing factors

false negative and false positive

report requirements)

and the limitations of this imaging technique were proposed. The future application prospects were also discussed. This specification aimed to promote the standardized application of

F-FES PET in China

achieve repeatability and comparability

and provide important molecular imaging technical support for accurate diagnosis and treatment of breast cancer.

关键词

Keywords

references

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The specification and use of 18F-FES PET in breast cancer

DOI：10.19401/j.cnki.1007-3639.2023.08.009

摘要

Abstract

关键词

Keywords

references

The specification and use of ¹⁸F-FES PET in breast cancer