Comparison of <sup>18</sup>F-FDG and <sup>68</sup>Ga-FAPI PET/CT in the diagnosis of lung metastasis in different malignant tumors

Ziyi YANG; Bingxin GU; Xiaoping XU; Shaoli SONG

doi:10.19401/j.cnki.1007-3639.2023.09.003

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Comparison of ¹⁸F-FDG and ⁶⁸Ga-FAPI PET/CT in the diagnosis of lung metastasis in different malignant tumors

Article | 更新时间：2025-12-31

- Comparison of ¹⁸F-FDG and ⁶⁸Ga-FAPI PET/CT in the diagnosis of lung metastasis in different malignant tumors
- China Oncology Vol. 33, Issue 9, Pages: 829-833(2023)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系，上海 200032
  2. 复旦大学生物医学影像研究中心，上海 200032
  3. 上海分子影像探针工程技术研究中心，上海 200032
  4. 上海市质子重离子医院核医学科，上海 201315
  5. 复旦大学核物理与离子束应用教育部重点实验室，上海 200433
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.09.003
  CLC： R730.44
- Received：30 May 2023，
  
  Revised：2023-09-05，
  
  Published：30 September 2023
- 稿件说明：
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Ziyi YANG, Bingxin GU, Xiaoping XU, et al. Comparison of ¹⁸F-FDG and ⁶⁸Ga-FAPI PET/CT in the diagnosis of lung metastasis in different malignant tumors[J]. China Oncology, 2023, 33(9): 829-833.
DOI：

Ziyi YANG, Bingxin GU, Xiaoping XU, et al. Comparison of ¹⁸F-FDG and ⁶⁸Ga-FAPI PET/CT in the diagnosis of lung metastasis in different malignant tumors[J]. China Oncology, 2023, 33(9): 829-833. DOI： 10.19401/j.cnki.1007-3639.2023.09.003.

摘要

背景与目的：

F-氟代脱氧葡萄糖（

F-flurodeoxyglucose，

F-FDG）正电子发射计算机体层成像（positron emission tomography and computed tomography，PET/CT）是诊断恶性肿瘤伴远处转移的常用方法，但对肺部转移灶尤其是小病灶的检测仍不理想。

Ga-成纤维细胞激活蛋白抑制剂（

Ga-labeled fibroblast activation protein inhibitors，

Ga-FAPI）已被用于靶向成纤维细胞激活蛋白和肿瘤基质的可视化。

Ga-FAPI PET/CT对大多数癌症的原发灶及其转移灶的诊断价值均高于

F-FDG，但至今尚未见到对恶性肿瘤肺部转移性病变的对比研究。因此，本研究旨在探讨

F-FDG和

Ga-FAPI PET/CT对不同恶性肿瘤肺转移病变的诊断价值。

方法：

回顾性分析复旦大学附属肿瘤医院2020年5月—2022年3月于1周内行

F-FDG和

Ga-FAPI PET/CT检查的20例恶性肿瘤肺转移患者的临床、病理学及影像学资料，其中上皮源性恶性肿瘤（癌）11例，间叶

源性恶性肿瘤（肉瘤）9例。采用配对

检验比较

Ga-FAPI和

F-FDG的病灶最大标准摄取值（maximum standard uptake value，SUV

max

)和肿瘤与本底比值（target-to-background ratio，TBR）参数之间的差异；采用线性相关性分析SUV

max

和TBR与肺转移灶短径之间的相关性。

结果：

20例患者共81个肺转移灶（51个来自癌转移，30个来自肉瘤转移），

F-FDG检出阳性病灶72个，

Ga-FAPI检查阳性病灶70个。与

Ga-FAPI相比，肺转移灶

F-FDG摄取值更高，尤其是癌来源的肺转移病灶（

0.001）。线性相关性分析结果显示，两种显像探针的半定量代谢参数值与肺转移病灶短径之间呈正相关（

0.001）。

结论：

Ga-FAPI在检测恶性肿瘤肺转移病变时并无明显优势，尤其是在上皮组织来源的恶性肿瘤肺转移诊断中，

F-FDG摄取值往往更高。

Abstract

Background and purpose:

F-flurodeoxyglucose (

F-FDG) positron emission tomography and computed tomography (PET/CT) is a common method for the diagnosis of malignant tumors with distant metastases. However the detection of lung metastases

especially small lesions

is still unsatisfactory.

Ga-labeled fibroblast activation protein inhibitors (

Ga-FAPI) have been used to target fibroblast activating proteins and visualize tumor stroma. The diagnostic value of

Ga-FAPI PET/CT is higher than that of

F-FDG in the primary sites and metastases of most cancers

but no comparative study has been seen in lung metastases of malignant tumors. Therefore

this study aimed to investigate the diagnostic value of

F-FDG and

Ga-FAPI PET/CT in different malignant lung metastases.

Methods:

The clinical

pathological and imaging data of 20 patients with lung metastasis who underwent

F-FDG and

Ga-FAPI PET/CT examination within one week in Fudan University Shanghai Cancer Center from May 2020 to March 2022 were retrospectively analyzed. Among them

11 cases were epithelial malignant tumors (carcinoma)

and 9 cases were mesophyll malignant tumors (sarcoma). The semi-quantitative metabolic parameters inclu

ding maximum standard uptake value (SUV

max

) and target-to-background ratio (TBR) of

Ga-FAPI and

F-FDG were compared by paired t test. The linear correlation between SUV

max

and TBR and the short diameter of lung metastasis were analyzed.

Results:

A total of 81 lung metastases (51 carcinomas and 30 sarcomas) were detected in 20 patients

72 positive lesions were detected by

F-FDG and 70 positive lesions by

Ga-FAPI. Compared with

Ga-FAPI

F-FDG uptake was higher in lung metastases

especially those of carcinoma (

0.001). The results of linear correlation analysis showed that the semi-quantitative metabolic parameters of the two imaging probes were positively correlated with the short diameter of lung metastases (

0.001).

Conclusion:

Ga-FAPI has no obvious advantage in the detection of lung metastases from malignant tumors. Especially in the diagnosis of lung metastases from epithelial tissues

the uptake of

F-FDG tends to be higher.

关键词

Keywords

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AI问答

⁰

Comparison of 18F-FDG and 68Ga-FAPI PET/CT in the diagnosis of lung metastasis in different malignant tumors

DOI：10.19401/j.cnki.1007-3639.2023.09.003

摘要

Abstract

关键词

Keywords

references

Comparison of ¹⁸F-FDG and ⁶⁸Ga-FAPI PET/CT in the diagnosis of lung metastasis in different malignant tumors