Research progress of the intratumoral microbiome

Xinran LI; Yiyi LIANG; Hong TU

doi:10.19401/j.cnki.1007-3639.2023.09.007

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Research progress of the intratumoral microbiome

Review | 更新时间：2025-12-31

- Research progress of the intratumoral microbiome
- China Oncology Vol. 33, Issue 9, Pages: 866-873(2023)
- 作者机构：
  
  1. 上海交通大学医学院附属仁济医院上海市肿瘤研究所，肿瘤系统医学全国重点实验室，上海 200032
  2. 复旦大学基础医学院，上海 200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.09.007
  CLC： R730.3
- Received：02 December 2022，
  
  Revised：2023-03-01，
  
  Published：30 September 2023
- 稿件说明：
移动端阅览
Xinran LI, Yiyi LIANG, Hong TU. Research progress of the intratumoral microbiome[J]. China Oncology, 2023, 33(9): 866-873.
DOI：

Xinran LI, Yiyi LIANG, Hong TU. Research progress of the intratumoral microbiome[J]. China Oncology, 2023, 33(9): 866-873. DOI： 10.19401/j.cnki.1007-3639.2023.09.007.

摘要

肿瘤内微生物组是指存在于肿瘤中并构成肿瘤微环境的微生物群体。虽然肿瘤病毒的研究已有百余年历史，但细菌、真菌等其他微生物在肿瘤中的存在现象及生物学意义却一直未有定论。近年来，随着高通量测序技术的发展，日益增多的证据表明，细菌等微生物确实能够存活于肿瘤组织中，并与肿瘤的发生、发展及耐药有一定的相关性。本文综述了肿瘤内微生物组的最新研究进展，总结了各肿瘤组织中微生物种群的特征及潜在功能，重点讨论了细菌微生物组在乳腺癌、胰腺癌和肺癌中的作用机制，并展望了其未来临床应用前景。

Abstract

Intratumoral microbiome is defined as the microbes that reside within tumor tissues to form the tumor microenvironment. Although substantial advances have been made in the research on virus infection and cancer during the past century

little is known about the existence and the role of intratumoral bacteria or fungi in cancer. In recent years

with the development of high-throughput sequencing technology

evidence has emerged to support the existence and functional activity of intratumoral bacteria. This review summarized the recent research progress in intratumoral microbiome

particularly their contribution to the carcinogenesis and chemoresistance of breast cancer

pancreatic cancer and lung cancer. The future perspectives of intratumoral microbiota in clinical application were also discussed.

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references

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